FINAL PROGRAM - American Society of Gene & Cell Therapy

13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010107Abstract DirectoryFriday, May 21, 2010Oral Abstract Session 324 — continuedPhysical Methods of Delivery2:00 PM - 4:00 PMRoom: Wilson ABC327 3:30 PMA Novel Prototype Device for Electroporation-Enhanced DNA VaccineDelivery to Both Skin and MuscleFeng Lin, Jay McCoy, Xuefei Shen, Janess Mendoza, Kate E. Broderick, Jian Yan, SteveKemmerrer, David B. Weiner, Niranjan Y. Sardesai.328 3:45 PMSafety and Feasibility of Transvenous Limb Perfusion with Saline inHuman Muscular DystrophyWilliam Powers, Zheng Fan, Keith Kocis, Robert Valley, Manisha Chopra, James Howard,Jr, Joseph Muenzer.Oral Abstract Session 325Cancer-Targeted Gene & Cell Therapy2:00 PM - 4:00 PMRoom: Thurgood Marshall W334 3:15 PMTumor-Selectivity of Replication-Competent Retrovirus (RCR) VectorsRegulated by Prostate-Specific Promoters and Cytotoxic Effect ofSuicide Gene Therapy Mediated by RCR Vectors In VitroShuichi Kamijima, Takahiro Kimura, Kazunori Haga, Kei Hiraoka, Akihito Inagaki,Christopher R. Logg, Chinghai Kao, Bernard H. Bochner, Noriyuki Kasahara.335 3:30 PMTranslational Phase I Study in Advanced Cancer Patients of Dual-Function Autologous (FANG) Vaccine Incorporating BifunctionalshRNA furin and GMCSF Transgene ExpressionNeil Senzer, Padmasini Kumar, Joseph Kuhn, Minal Barve, Cynthia Bedell, Yang Yu, AlexW. Tong, Phillip B. Maples, John Nemunaitis.336 3:45 PMEfficient Gene Transfer in Quiescent Healthy and Cancer B Cells by aMeasles Virus gp Pseudotyped LVCecilia Frecha, Caroline Costa, Camille Levy, Didier Negre, Andrea Maisner, Stephen J.Russell, Nicholas Rachinel, Gilles Salles, Francois-Loic Cosset, Els Verhoeyen.Oral Abstract Session 326Hematologic/Immunologic: Basic2:00 PM - 4:00 PMRoom: Maryland Suite329 2:00 PMA Genetically Engineered Multifunctional Vector for HER2 TargetedCancer Suicide Gene TherapyYuhua Wang, Arash Hatefi.330 2:15 PMComparative Analysis of Enzyme and Pathway Engineering Strategiesfor Suicide Gene Therapy ApplicationsAdam J. Johnson, Andressa Ardiani, Kinta Serve, Marilyn Sanchez-Bonilla, Margaret E.Black.331 2:30 PMConditional and Effective Gene Knock-Down in ProangiogenicMacrophages To Disrupt Tumor AngiogenesisFerdinando Pucci, Roberta Mazzieri, Bernhard Gentner, Luigi Naldini, Michele De Palma.332 2:45 PMCell Fusion between Mesenchymal Stem Cells and Cancer Cells: AMechanism of Cancer ProgressionYan Xiao, Dirk H. Hondmann, Carla J. Aldrich, Chenzhong Kuang.333 3:00 PMNext-Generation Lentiviral Cell Fate Control Gene Therapy Based onEngineered Variants of Human Deoxycytidine KinaseAnton Neschadim, Arnon Lavie, Takeya Sato, Daniel H. Fowler, Vladimir Ponomarev,Jeffrey A. Medin.337 2:00 PMSafely Exploiting Hematopoeitic Stem and Progenitor Cell SpecificmicroRNAs To Target Transgene Expression to the DifferentiatedProgenyBernhard Gentner, Alice Giustacchini, Francesco Boccalatte, Massimo Saini, Giulia Schira,Luigi Naldini.338 2:15 PMTherapeutic Fetal Hemoglobin Production in Erythroid Progeny ofNormal and b-Thalassemic Human CD34 + Cells Using LentiviralVectors Encoding g-Globin or shRNA To Down Modulate theTranscriptional Repressor BCL11AAndrew Wilber, Vijay G. Sankaran, Phillip W. Hargrove, Yoon-Sang Kim, EleniPapanikolaou, Nicholas P. Anagnou, Stuart H. Orkin, Arthur W. Nienhuis, Derek A.Persons.339 2:30 PMPotentially Therapeutic Levels of Fetal Hemoglobin in ErythroidProgeny of Normal and b-Thalassemic CD34 + Cells FollowingLentivirus-Mediated Delivery of a Zinc-Finger TranscriptionalActivator Targeting the g-Globin Gene PromotersAndrew Wilber, Ulrich Tschulena, Phillip W. Hargrove, Yoon-Sang Kim, Carlos F. Barbas,III, Derek A. Persons, Arthur W. Nienhuis.340 2:45 PMDevelopment of an S/MAR Based Episomal Vector of a Specific Zinc-Finger Activator That Mediates Gamma-Globin Gene Activation, forthe Gene Therapy of HemoglobinopathiesEleana Stavrou, Eleni Lagadinou, Nikolas Zoumbos, Alexandros Spyridonidis, CarlosBarbas, III, Kenneth Peterson, Aglaia Athanassiadou.Friday, May 21 st