13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010117Abstract DirectoryFriday, May 21, 2010Poster Session II — continued6:30 PM - 8:30 PMRoom: Exhibit Hall C & B-SouthCancer-Oncolytic Viruses II502Silencing a p53 Inhibitor in Cancer <strong>Cell</strong>s Increases Killing Potency <strong>of</strong>Oncolytic AdenovirusChristie Vermeulen, Nikki Tol, Winald R. Gerritsen, Victor W. van Beusechem.503Safety <strong>of</strong> Intravenous Ad5-Mda-7, a Potential Anti-Metastatic Agentin Gynecologic CancerKenneth H. Kim, Meredith A. Preuss, Minghui Wang, Anand C. Annan, Justin A. Barnes,Devanand Sarkar, Steven Grant, Paul Dent, Paul B. Fisher, Ronald D. Alvarez, David T.Curiel.504Characterization <strong>of</strong> a Novel Dual-Lock Oncolytic Cadvex-VectorThat Combines Efficient Prostate-Specific Replication with CytokineExpressionBrian D. Hoel, Min Luo, David A. Einfeld, Danher Wang, John Y. Dong.505A Probasin Promoter, Conditionally Replicating Adenovirus thatExpresses the Sodium Iodide Symporter (NIS) for Radiovirotherapy<strong>of</strong> Prostate CancerMiguel A. Trujillo, Michael J. Oneal, Samantha McDonough, Rui Qin, John C. Morris.506Adenovirus Vectors Transductionally Retargeted to Her2/neu forProstate Tumour TreatmentMaria K. Magnusson, Robert Kraaij, Corrina M. A. De Ridder, Leif Lindholm.Cancer-Targeted <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> II507The Potential <strong>of</strong> Conditionally Replicating Adenovirus ExpressingTIMP2 for Ovarian Cancer <strong>Therapy</strong>Sherry W. Yang, James J. Cody, Joanne T. Douglas, Ronald D. Alvarez, SelvaranganPonnazhagan.508Mechanisms <strong>of</strong> the Tmpk/AZT-System Bystander Effect; <strong>Cell</strong> FateControl <strong>Gene</strong> <strong>Therapy</strong> for Anti-Cancer TreatmentTakeya Sato, Anton Neschadim, Jun Sukegawa, Teruyuki Yanagisawa, Jeffrey A. Medin.509Truncated CD19 Fused with Mutant Human Tmpk: A Versatile <strong>Cell</strong>Fate Control Safety CassetteMatthew D. Scaife, Sean P. Devine, Anton Neschadim, Natalia A. Pacienza, Daniel H.Fowler, Jeffrey A. Medin.510Muscle Directed Systemic Cancer <strong>Gene</strong> <strong>Therapy</strong> for Lymphoma UsingType 8 AAV Vector Expressing mda-7/IL24Nanya Wang, Bai Fan, Koichi Miyake, Noriko Miyake, Takashi Shimada.511A Liposome Formulation with High Accumulation in Tumor Tissue forTargeted Delivery <strong>of</strong> Nucleic AcidTorben Gjetting, Camilla L. Christensen, Frederik Cramer, Hans S. Poulsen, Thomas L.Andresen.51215-LO-1 Induced Apoptosis Inhibits Tumour Growth and ExtendsSurvival in Rat Glioma ModelAgnieszka Pacholska, Helena Viita, Farizan Ahmad, Anna Hyvärinen, Thomas Wirth,Seppo Ylä-Herttuala.513An Efficient Targeted <strong>Gene</strong> <strong>Therapy</strong> Using Brain Tumor-SpecificPromoterToshio Yawata, Eri Ishida, Yu Kawanishi, Masakazu Tamura, Keiji Shimizu.514Nitric Oxide Synthase One Homologous Recombinant Negative(NOS1 -/-) Mice Are Protected from Thoracic Irradiation InducedSeizures by Esophageal Administration <strong>of</strong> Manganese SuperoxideDismutase Plasmid Liposome Complex (MnSOD-PL)Malolan Rajagopalan, Jean-Claude Rwigema, Brandon Stone, Michael Epperly, JulieG<strong>of</strong>f, Tracy Dixon, Darcy Franicola, Joel Greenberger.515Maternal Manganese Superoxide Dismutase Plasmid/LiposomeComplex (MnSOD-PL) <strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> E13 Pregnant Mice ReducesTotal Body Irradiation Induced Growth Retardation in Newborn MiceMichael Epperly, Tracy Dixon, Xichen Zhang, Benjamin Greenberger, Paavani Komanduri,Hong Wang, Joel Greenberger.516Adenovirus-Relaxin <strong>Gene</strong> <strong>Therapy</strong> on Keloids: AttenuatedProliferative Response and Collagen DegradationIl-Kyu Choi, Il-Kyu Lee, Yong Oock Kim, Dong Kyun Rah, Chae-Ok Yun.517Inducing Systemic Anti-Tumor Immune Responses through DirectTumor TargetingG. Campbell Kaynor, Liaomin Peng, Jorge Sanchez-Salazar, Yang-Xin Fu, XinzhongWang.518Angiotensin Type 2 Receptor Mediated Apoptosis <strong>of</strong> Human ProstateCancer <strong>Cell</strong>sHongwei Li, Yanfei Qi, Chengyao Li, Leah N. Braseth, Yongxin Gao, Arseniy E. Shabashvili,Michael J. Katovich, Colin Sumners.519 Abstract Withdrawn520Regulatory Submission Process for <strong>Gene</strong> and <strong>Cell</strong>ular TherapiesGladice Wallraven, Phillip B. Maples, John Nemunaitis.Friday, May 21 st
118<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectoryFriday, May 21 stFriday, May 21, 2010Poster Session II — continued6:30 PM - 8:30 PMRoom: Exhibit Hall C & B-SouthHematologic and Immunologic <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> II521Lentiviruses Containing a Modified Ankyrin-1 Promoter DirectUniform, Copy-Number-Dependent Expression <strong>of</strong> a g-Globin <strong>Gene</strong> atTherapeutic LevelsFaith Harrow, Karina Laflamme, Amanda Cline, David M. Bodine.522Non-Myeloablative Conditioning Regimen To Increase Engraftment <strong>of</strong><strong>Gene</strong>-Modified Hematopoietic Stem <strong>Cell</strong>sTeiko Sumiyoshi, Chang J. Lee, Roger Hollis, Francesca Giannoni, Stan F. Louie, Alice F.Tarantal, Donald B. Kohn.523In Vivo Selection <strong>of</strong> Hematopoietic Stem <strong>Cell</strong>s by Expressing aTruncated Epo Receptor (tEpoR)Maria Rosa Lidonnici, Francesca Tiboni, Giacomo Mandelli, Claudia Cattoglio, MargheritaGalletti, Alexis Grande, Fulvio Mavilio, Giuliana Ferrari.524Successful Treatment <strong>of</strong> Canine Leukocyte Adhesion Deficiency Usinga SIN Lentiviral Vector with the PGK Promoter Expressing CanineCD18Michael J. Hunter, Huifen Zhao, Laura M. Tuschong, Tanya H. Burkholder, Derek A.Persons, Dennis D. Hickstein.525Diminished End Organ Damage and Correction <strong>of</strong> Anemia in Sickle<strong>Cell</strong> Mice Treated with Non-Myeloablative Busulfan Conditioning andg-Globin Lentiviral Vector Transduced HSCsTamara I Pestina, Phillip W. Hargrove, Huifen Zhao, Peter Vogel, Derek A. Persons.526Small but Powerful, Predicting the Outcome <strong>of</strong> <strong>Gene</strong> <strong>Therapy</strong> TrialUsing NSG MiceTomoyasu Higashimoto, Elke Grassman, Jose A. Cancelas, Punam Malik.527Development <strong>of</strong> a Bioengineered Recombinant Factor VIII TherapeuticUsing a Lentiviral Production PlatformChristopher B. Doering, Gabriela Denning, Richard Gautney, Boro Dropulic, Lajos Baranyi,Andre J. Roy, Bagirath Gangadharan, Ernest T. Parker, Pete Lollar, H. Trent Spencer.528Transgenic Expression <strong>of</strong> Cytidine Deaminase (CDD) forMyeloprotective PurposesNico Lachmann, Nils Pfaff, Sebastian Brennig, Doreen Lüttge, Tobias Cantz, ChristopherBaum, Axel Schambach, Thomas Moritz.529Development <strong>of</strong> a Pre-Clinical Model for the <strong>Gene</strong> <strong>Therapy</strong> Treatment<strong>of</strong> Wiskott-Aldrich Syndrome (WAS)Alexander Astrakhan, Byoung Ryu, Brigid Stirling, Blythe Sather, Jit Khim, MikhailGaribov, Stephanie Humblet-Baron, Hans Ochs, David J. Rawlings.530Lentiviral <strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> Murine Hematopoietic Stem <strong>Cell</strong>s UsingCodon Optimized IL2RG cDNA: A Comparison <strong>of</strong> Multiple PromoterElements and Transplant ConditionsMarshall W. Huston, Niek P. van Til, Trudi P. Visser, Roya Sawari, Shazia Arshad, GerardWagemaker.531Human Fetal Liver HSCs Demonstrate High Transduction Rates andSustained Transgene Expression Following ImplantationNiraja Dighe, Maroun Khoury, Mark Chong, Citra Mattar, Michael N. Antoniou, JianzhuChen, Mahesh Choolani, Jerry Chan.532FANG Autologous Tumor <strong>Cell</strong> Vaccine Development and ManufacturingPhillip B. Maples, Padmasini Kumar, Yang Yu, Beena O. Pappen, Chris M. Jay, ZhaohuiWang, Donald D. Rao, Joseph Kuhn, John Nemunaitis, Neil Senzer.533Atomic Force Microscopy (AFM) Shows Lower Membrane Resistance<strong>of</strong> Human T <strong>Cell</strong>s Rendered Deficient in WASP by RNAiVéronique Pariétti, Ruthger Van Zwieten, Malgorzata Lekka, Nicolas Mermod, Anne Galy.534A Combination <strong>of</strong> Codon Optimization and Amino Acid Substitution inthe Human Factor IX <strong>Gene</strong> Yields a High Level <strong>of</strong> Superactive FactorIXThipparat Suwanmanee, William Hannah, Tong Gui, Hong Ma, Adam S. Cockrell, PaulE. Monahan, Tal Kafri.Immunologic & Host Responses in <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>535In Vivo Expansion <strong>of</strong> Regulatory T <strong>Cell</strong>s with IL2-mAb ComplexesPrevents and Modulates Anti-Factor VIII Immune Responses inHemophilia A Mice after Factor VIII Plasmid-Mediated <strong>Gene</strong> <strong>Therapy</strong>Chao-Lien Liu, Peiqing Ye, Benjamin Yen, Baowei Peng, Carol H. Miao.536Phase I Safety and Pharmacokinetic Study <strong>of</strong> Systemic p53 <strong>Gene</strong><strong>Therapy</strong> (SGT-53) Using Immunolipoplexes Targeted by Anti-Transferrin Receptor (TfR) Single Chain Antibody Fragment (scFv):Updated ResultsNeil Senzer, John Nemunaitis, Cynthia Bedell, Robert Nunan, Henry Allen, Leanne Sleer,Esther Chang.537Induction <strong>of</strong> Type I Interferon (IFN) by Adenovirus-Encoded SmallRNAsTomoko Yamaguchi, Kenji Kawabata, Emi Kouyama, Takayuki Suzuki, Fuminori Sakurai,Shinnosuke Kurachi, Kazufumi Katayama, Hiroyuki Mizuguchi.EXHIBITOR PROSPECTUSfinal program
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