13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010137Abstract DirectorySaturday, May 22, 2010Poster Session III — continued6:00 PM - 8:00 PMRoom: Exhibit Hall CCancer – Immunotherapy III827Strategy Escalation: An Emerging Paradigm for Safe ClinicalDevelopment <strong>of</strong> T <strong>Cell</strong> <strong>Gene</strong> TherapiesR. P. Junghans.Cancer-Oncolytic Viruses III828Combination <strong>of</strong> Promoter and microRNA Detargeting Is GreatlyAdvantageous in Attenuation <strong>of</strong> Adenoviral Replication in Hepatic<strong>Cell</strong>sJustyna Leja, Berith Nilsson, Di Yu, Magnus Essand.829Combining Oncolytic Herpes Simplex Virus and Chemotherapy: G47Dand Temozolomide Synergize in Killing Glioma Stem <strong>Cell</strong>sRyuichi Kanai, Hiroaki Wakimoto, Robert L. Martuza, Samuel D. Rabkin.830Transcriptional Targeting <strong>of</strong> an Oncolytic HSV-1 to Midkine-PositiveTumorsArturo R. Maldonado, Chuck Klanke, Anil G. Jegga, Bruce J. Aronow, Yonatan Y. Mahller,Timothy P. Cripe, Timothy M. Crombleholme.831Preclinical Studies Support the Efficacy <strong>of</strong> Prodrug Activator <strong>Gene</strong>Transfer in Experimental Glioma Models by Enhanced Replication-Competent Retrovirus VectorAkihito Inagaki, Kei Hiraoka, Christopher R. Logg, Hiroshi Matsumoto, Joan Robbins,Omar Perez, Harry Gruber, Douglas Jolly, Noriyuki Kasahara.832Intrapleural Administration <strong>of</strong> Third <strong>Gene</strong>ration Oncolytic HSV-1 (G47D) Is Highly Efficacious in Orthotopic Malignant PleuralMesothelioma ModelsMasamichi Takahashi, Yasushi Ino, Nobuhito Saito, Tomoki Todo.833Engineered Measles Viruses for Oncolytic <strong>Therapy</strong> <strong>of</strong> PancreaticCancerSascha Bossow, Christian Grossardt, Stefanie Sawall, Christoph Springfeld, AchimTemme, Roberto Cattaneo, Christ<strong>of</strong> von Kalle, Guy Ungerechts.834Incorporation <strong>of</strong> a Mutated E1A and a Chimeric 5/3 Fiber Improvedthe Therapeutic Efficacy <strong>of</strong> a Novel CRAd (Ad-F512) on DisseminatedOvarian CancerVeronica M. Lopez, Angel A. Rivera, Lorena Benedetti, Diego L. Viale, Kristopher J.Kimball, Minghui Wang, Alicia J. Bravo, Christine Dorvault, Joanne Douglas, Zeng B. Zhu,Ronald D. Alvarez, David T. Curiel, Osvaldo L. Podhajcer.835Inhibition <strong>of</strong> Autophagy Has Negative Impact on Virus ProductionIlya V. Ulasov, Atique U. Ahmed, Bart Thaci, Natalya V. Kaverina, Maciej S. Lesniak.836Armed and Transcriptionally Driven Oncolytic HSV-1 EnhancesAntitumor Efficacy In Vitro and In VivoJi-Young Yoo, Amy Haseley, Anna Bratasz, Kimerly Powell, Balveen Kaur.837Determining Adenovirus Titers Following Extraction <strong>of</strong> the Virus fromTumors in the Presence <strong>of</strong> Anti-Adenovirus AntibodiesDebanjan Dhar, Karoly Toth, William S. M. Wold.838 Abstract Withdrawn839The Use <strong>of</strong> Third <strong>Gene</strong>ration Oncolytic HSV-1 Expressing Luciferasefor Demonstration <strong>of</strong> Real-Time Biodistribution and DynamicsYihan Wu, Yasushi Ino, Tomoki Todo.840Highly Attenuated Vaccinia Virus as a Potential Oncolytic Agent forCancer VirotherapyTakafumi Nakamura, Minoru Kidokoro, Mina Hikichi, Hisatoshi Shida, Hideaki Tahara.841Enhanced Tumor Killing by a Mortalin Targeting Modified OncolyticAdenovirusJung-Sun Lee, Ji Young Yoo, Jihoon Ryu, Tomoko Yaguchi, Sunil C. Kaul, Renu Wadhwa,Chae-Ok Yun.842Increased Oncolytic Ability <strong>of</strong> a Double RGD-Modified Adenovirus inOvarian CancerLena J. Gamble, Qiana L. Matthews, Anton V. Borovjagin, David T. Curiel.Cancer-Targeted <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> III843Increasing the Efficacy <strong>of</strong> Monoclonal Antibody <strong>Therapy</strong> <strong>of</strong> BreastCancer through Transient Remodeling <strong>of</strong> Intercellular JunctionsJonas Persson, Max Drescher, ZongYi Li, Roma Yumul, Ying Liu, Hongjie Wang, AkseliHemminki, Pascal Fender, Andre Lieber.844Improvement <strong>of</strong> Cancer <strong>Gene</strong> <strong>Therapy</strong> by Incorporating a ChickenHypersensitive Site-4 Insulator into TSTA-Based Tumor-TargetingVectorChien-Fu Chen, Yu-Ping Sher, Mien-Chie Hung, Chia-Ling Hsieh.Saturday, May 22 nd
138<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectorySaturday, May 22 ndSaturday, May 22, 2010Poster Session III — continued6:00 PM - 8:00 PMRoom: Exhibit Hall CCancer-Targeted <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> III845Cytokine Induced Killer (CIK) <strong>Cell</strong>s for <strong>Cell</strong> <strong>Therapy</strong> <strong>of</strong> AcuteMyeloid Leukemia (AML): Improvement <strong>of</strong> Their Immune Activity byExpression <strong>of</strong> CD33-Specific Chimeric Receptors (CR)Virna Marin, Irene Pizzitola, Valentina Agostoni, Helene Finney, Alastair Lawson, MartinPule, Raphael Rousseau, Andrea Biondi, Ettore Biagi.846Exosome-Mediated Suicide <strong>Gene</strong> <strong>Therapy</strong> for Brain TumorsArda Mizrak, Senol Ozlem, Baris G. Ozdener, Leonora Balaj, Johan Skog, Xandra O.Breakefield, Okay Saydam.847Eradication <strong>of</strong> <strong>Therapy</strong>-Resistant Human Prostate Tumors Using anUltrasound Guided Site-Specific Cancer Terminator Virus DeliveryApproachPier Paolo Claudio, Rounak Nande, Mary A. Teter, Paul B. Fisher, Sarkar Denavand, LuigiClaudio, Adelaide Greco, Candace Howard.848Systemic Tumour Targeting with Orally Administered Non-PathogenicBacteriaMichelle Cronin, David Morrissey, Simon Rajendran, Douwe van Sinderen, Gerald C.O’Sullivan, Mark Tangney.849Transient Intratumoral Relaxin Expression Results in Tumor StromaDegradation and Improves Breast Cancer <strong>Therapy</strong> by HerceptinZongYi Li, Ying Liu, Roma Yumul, Max Drescher, Jonas Persson, Ines Beyer, Andre Lieber.850Developing a Multi-Modal <strong>Gene</strong>-Based Imaging and <strong>Therapy</strong> To TreatDisseminated Hormone Refractory Prostate CancerZiyue Jiang, Makoto Sato, Lily Wu.851Adenoviruses-Mediated Expression and <strong>Cell</strong>-Mediated Delivery <strong>of</strong>Interferon-Lambda Produced Anti-Tumor Effects to Human EsophagealCarcinoma In VivoMasatoshi Tagawa, Quanhai Li, Kiyoko Kawamura, Shinya Okamoto, Shan Yang, HiroshiKobayashi, Muneo Numasaki, Yuji Tada, Kenzo Hiroshima, Hideaki Shimada.852Inhibition <strong>of</strong> Angiogenesis and Suppression <strong>of</strong> Colorectal CancerMetastatic to the Liver Using the Sleeping Beauty Transposon SystemLalitha R. Belur, Kelly M. Podetz-Petersen, Brent Sorenson, Josh Parker, Cathy Carlson,Daniel Saltzman, Ramakrishnan Sundaram, R. Scott McIvor.853Plasmid AMEP, a New Efficient Antitumor <strong>Gene</strong> Transfer Product forthe Treatment <strong>of</strong> Metastatic MelanomasCeline Bouquet, Veronique Trochon-Joseph, Valerie Polard, Lluis M. Mir, MichelPerricaudet, Sophie Lebel-Binay.854Adenovirus-Delivered Short Hairpin-Structured RNA for MicrophageMigration Inhibitory Factor Silencing Inhibits Human Prostate Cancer<strong>Cell</strong> ProliferationLing Zhang, Anqi Wang, Chengyao Li, Hongwei Li, Leah N Braseth, Arseniy E Shabashvili,Colin Sumners.855Monitoring <strong>of</strong> Electroporation-Mediated Diphtheria Toxin AExpression in Prostate Cancer <strong>Cell</strong>s Grown in SCID MiceChristine Goepfert, Felix J. Frey, Brigitte M. Frey.856Clinical <strong>Gene</strong> Transfer in the Community: Ten Years <strong>of</strong> Local IBCReviewJan P. Vleck.Hematologic and Immunologic <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> III857High Incidence <strong>of</strong> Vector Integration near Cancer-Related <strong>Gene</strong>swithin Primitive Hematopoietic Stem <strong>Cell</strong>s (HSC) after Fetal <strong>Gene</strong>Transfer with g-Retroviral VectorsJoe Tellez, Josh Wood, Graça Almeida-Porada, Chris D. Porada.858Successful Treatment <strong>of</strong> Canine Leukocyte Adhesion Deficiency Usinga MSCV-Promoter Based Foamy Viral Vector and Low-Dose BusulfanConditioningThomas R. Bauer, Jr., Erik M. Olson, Laura M. Tuschong, James M. Allen, Tanya H.Burkholder, David W. Russell, Dennis D. Hickstein.859<strong>Gene</strong>tically Engineered VIP-Expressing Dendritic <strong>Cell</strong>s Are Therapeuticin the Autoimmune Mouse Model <strong>of</strong> Experimental AutoimmuneEncephalomyelitisMiguel G. Toscano, Mario Skarica, Weiming Kong, Doina Ganea.860Long-Term Preclinical Evaluation <strong>of</strong> Lentiviral Vectors for SCID-X1<strong>Gene</strong> <strong>Therapy</strong> in a SCID-X1 Mouse ModelSheng Zhou, Suk See DeRavin, Zhijun Ma, Taihe Lu, John T. Gray, Harry L. Malech, BrianP. Sorrentino.861Transduction <strong>of</strong> Human CD34+ Derived NOG Repopulating <strong>Cell</strong>s withan Insulated SIN Lentiviral Vector for SCID-X1 Produced from aStable Producer <strong>Cell</strong> LineMichael R. Greene, Yoon-Sang Kim, Timothy Lockey, Paolo Fagone, Robert E. Throm,John T. Gray, Derek A. Persons, Brian P. Sorrentino.EXHIBITOR PROSPECTUSfinal program
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