13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010109Abstract DirectoryFriday, May 21, 2010Poster Session II— continued6:30 PM - 8:30 PMRoom: Exhibit Hall C & B-SouthRNA Virus Vectors I357‘Self’ Marker CD47 on Viral EnvelopesNisha Sosale, Richard K. Tsai, Irena Ivanovska, Philip W. Zoltick, Dennis E. Discher.358Lentiviral Microarrays for High-Throughput and Real-Time Monitoring<strong>of</strong> <strong>Gene</strong> Expression DynamicsJun Tian, Stella Allimperti, Pedro Lei, Stelios T. Andreadis.359Fibrin-Conjugated Pseudotyped Lentivirus for <strong>Cell</strong>-Controlled andSpatially Localized <strong>Gene</strong> Delivery on Microarrayed SurfacesRoshan Padmashali, Pedro Lei, Stelios Andreadis.360Improved Transduction Efficiency <strong>of</strong> Human Amniotic MesenchymalStem <strong>Cell</strong>s Using Optimized Lentiviral VectorsF. Pisano, P. Danieli, E. Cervio, C. Ciuffreda, M. Roccio, G. Viarengo, M. Gnecchi.361Purification <strong>of</strong> Lentivirus Vector by Iodixanol Self-Forming DensityGradientJulia Transfiguracion, Sven Ansorge, Rosa Tran, Amine Kamen.AAV Vectors II362rAAV-Mediated Delivery <strong>of</strong> Micro RNA Scavengers Leads to Efficientand Stable Knock-Down <strong>of</strong> Cognate Micro RNAs, Upregulation <strong>of</strong>Their Natural Target <strong>Gene</strong>s and Phenotypic Changes in MiceJun Xie, Jennifer Broderick, Qing Xie, Hongwei Zhang, Ran He, Qin Su, Phillip D.Zamore, Guangping Gao.363Activation <strong>of</strong> the Non-Canonical NF-kB Pathway by AAV2 Vectors:Implications in Immune Response and <strong>Gene</strong> <strong>Therapy</strong>Giridhara R. Jayandharan, George Aslanidi, George Q. Perrin, Li Zhong, Angela E. Rivers,Ashley T. Martino, Roland W. Herzog, Arun Srivastava.364Multifunctional Peptide Ligands for AAV Capsid RecognitionNagesh Pulicherla, Jana L. Phillips, Aravind Asokan.365The Rous Sarcoma Virus Promoter Carried by a rAAV Vector IsResistant to DNA Methylation in Primate Muscle and LiverAdrien Léger, Magalie Penaud-Budloo, Michael L. Nickerson, Caroline Le Guiner, PhilippeMoullier, Richard O. Snyder.366The Hybrid AAV2.5 Vector Transduces Neurons Bordering the Thirdand Fourth Ventricles after Lateral Ventricular Infusion in RatsDawn E. Bowles, Chengwen Li, Joseph E. Rabinowitz, R. Jude Samulski, Thomas J.McCown.367Differential Lymphatic Transport <strong>of</strong> Chimeric and Naturally OccurringAAV StrainsJana L. Phillips, Roland Cheung, Chengwen Li, Aravind Asokan.368Optimizing Liver Transduction <strong>of</strong> the Low Seroprevalent AAV rh32.33Luk H. Vandenberghe, Ru Xiao, James M. Wilson.369Role <strong>of</strong> a <strong>Cell</strong>ular Chaperone Protein, FKBP52, in Uncoating <strong>of</strong> AAV2VectorsMengxin Li, Giridhara R. Jayandharan, Baozheng Li, Chen Ling, Wenqin Ma, ArunSrivastava, Li Zhong.370Strategies To Achieve Enhanced Transduction <strong>of</strong> Primary HumanDendritic <strong>Cell</strong>s by AAV2 Vectors and Reduced Cytotoxic T <strong>Cell</strong>Response to Viral Capsids and Transgene ProductsGeorge Aslanidi, George Q. Perrin, Giridhara R. Jayandharan, Angela E. Rivers, Li Zhong,Arun Srivastava.371Optimizing Capsid Composition for the Production <strong>of</strong> RecombinantAdeno-Associated Virus Using the Baculovirus Expression SystemKirsten Erger, David Markusic, Ramaz Geguchadze, Barry J. Byrne, Sergei Zolotukhin.372<strong>Gene</strong>tically Re-Engineered AAV Rep78 Identifies Sequence-RestrictedInhibitory Regions Affecting Adenoviral ReplicationVarsha Sitaraman, Patrick Hearing, Steffen Mueller, Charles Ward, Dmitri Gnatenko,Steven Skiena, Eckard Wimmer, Wadie F. Bahou.373Improved and Persistent Expression with Novel AAV Serotypes forNeonatal <strong>Gene</strong> <strong>Therapy</strong>Chuhong Hu, Fides D. Lay, Joseph Springer, Ronald W. Busuttil, Gerald S. Lipshutz.374Optimization <strong>of</strong> AAV Vectors for Improved Therapeutic ProteinExpression in the Canine Models for Duchenne Muscular DystrophyAlock Malik, Marilyn Mitchell, Andrew Mead, Mike Petrov, Hansell Stedman.375rAAV1 Infect Mouse Bone Marrow-Derived Dendritic <strong>Cell</strong>s throughReceptors with a2,3 and a2,6 Sialic AcidsYuanqing Lu, Sihong Song.376Using AAV Vector as Carrier for Biosensor: Detecting microRNA’sActivities by Reverse Infection <strong>of</strong> AAV VectorsWenhong Tian, Xiaoyan Dong, Gang Wang, Shuping Tan, Xiaobing Wu.Friday, May 21 st
110<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectoryFriday, May 21 stFriday, May 21, 2010Poster Session II— continued6:30 PM - 8:30 PMRoom: Exhibit Hall C & B-South377Clearance <strong>of</strong> Herpes Simplex Virus by Orthogonal ManufacturingProcess <strong>of</strong> Recombinant Adeno-Associated Virus (rAAV) VectorsGuo-jie Ye, David R. Knop, Darby L. Thomas, Lijun Wang, Jeffrey D. Chulay.Adenovirus and Other DNA Virus Vectors II378Production <strong>of</strong> a Novel Class <strong>of</strong> Human Polyomavirus JC Vectors UsingBaculovirus Expression SystemKirsten E. Erger, Oleg Gorbatyuk, George Aslanidi, Ramaz Geguchadze, Barry J. Byrne,Sergei Zolotukhin.379Induction <strong>of</strong> <strong>Cell</strong> Surface Integrins in Lymphomas and PotentialApplications to <strong>Gene</strong> <strong>Therapy</strong>Ann Marie O’Neill, Farruk M. L. Kabir, David T. Curiel, Laura Timares, Bruce F. Smith.380FX-Binding Ablated Ad5 Do Not Transduce Hepatocytes but ExhibitSplenic Uptake at High DosesRaul Alba, Angela C. Bradshaw, Robert A. McDonald, Lynda Coughlan, Alan L. Parker,Ashley M. Miller, Nico van Rooijen, Stuart A. Nicklin, Andrew H. Baker.381Targeting Adenovirus <strong>Cell</strong> Entry Via Tumor-Associated EphA2 byInsertion <strong>of</strong> a Ligand Peptide into Different Loops <strong>of</strong> the Short Fiber<strong>of</strong> Ad41Michael Behr, Dirk M. Nettelbeck.382Induction <strong>of</strong> a Prostate Specific Promoter and Replication Kinetics byp21/Waf-1 shRNA Armed CRAdNaser Uddin Hoti, Sadaf Mustafa, Wasim Chowdhury, Ronald Rodriguez.383Capacitance-Based Real Time Monitoring <strong>of</strong> Virus TransductionJoung-Woo Choi.384Inhibition <strong>of</strong> PD-1 Greatly Augments Therapeutic Effect <strong>of</strong> Suicide<strong>Gene</strong> <strong>Therapy</strong> for Gastrointestinal CancersHae-hyun Seo, Mi-Hyang Lee, In-Hoo Kim, Seong-Phil Shin, Kyung-Hee Chun, Sang-JinLee.385Method for Fast and Easy Adoption <strong>of</strong> First-<strong>Gene</strong>ration AdenoviralVectors to High-Capacity Adenoviral VectorsMartin A. Hausl, Christina Rauschhuber, Richard Voigtlander, Zsolt Ruzsics, Anja Ehrhardt.386PAUF Targeting RNA-Based <strong>Gene</strong> <strong>Therapy</strong>Sue Kyung Kim, Eun Ok Kim, Hyun Mi Dae, Ju Young Moon, Kyun Heo, In-Hoo Kim,Yun-Hee Kim.387Combining Oncolytic Adenoviruses and Antibody <strong>Therapy</strong>Dominik E. Dorer, Roland Kontermann, Dirk M. Nettelbeck.388Direct Injection <strong>of</strong> HDAd into the Liver Is as Effective but Less ToxicThan Intravenous Injection for Crigler-Najjar Syndrome <strong>Gene</strong> <strong>Therapy</strong>Franesco Vetrini, Nathan Grove, Donna Palmer, Philip Ng, Nicola Brunetti-Pierri.389Dual-Expression Adenoviral Vectors as Vaccine CarriersXiangyang Zhou, Heng Chen, Dongming Zhou, Ang Bian, Hildegund C. Ertl.390Optimized Adenovirus Targeting through Virus-Displayed PeptideLibrary Screening in a Prostate Cancer ModelPing Wu, Tarana A. Kudrolli, Wasim H. Chowdhury, Minzhi M. Liu, Ronald Rodriguez,Shawn E. Lupold.391Human Adenovirus Type 40 Vector Engineering for Intestinal MucosaTargetingSatoshi Yamasaki, Eric Brown, Julia Davydova, Selwyn M. Vickers, Masato Yamamoto.Chemical and Molecular Conjugates II392Macropinocytosis Is the Major Pathway Leading to Transfection for aCharge-Reversal AmphiphileXiao-Xiang Zhang, Phil Allen, Mark W. Grinstaff.393Ornithine-Based Cationic Lipids: Highly Charged DendriticHeadgroups, New Lipoplex Phases and Degradable LipidsKai K. Ewert, Alexandra Zidovska, Rahau S. Shirazi, Joel Quispe, Bridget Carragher,Clinton S. Potter, Cyrus R. Safinya.394Nanoparticle-Mediated Delivery <strong>of</strong> <strong>Gene</strong>s and Imaging Agents to theBrainStephen L. Hart, Alison Bienemann, Steven Gill, Panos Kyrtatos, Andrew S. Lowe, MarkLythgoe, Edward A. White, Michele J. Writer.395In Vitro and In Vivo Transfection Efficiency <strong>of</strong> DNA NanoparticlesMade with Histidinylated lPEI and Plasmid DNA Containing NFkBDNA Binding SequencePatrick Midoux, Gilles Breuzard, Ludivine Billiet, Emilie Bertrand, Tony Le Gall, TristanMontier, Pierre Lehn, Hervé Chéradame, Chantal Pichon, Philippe Guégan.EXHIBITOR PROSPECTUSfinal program
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