13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010 95Abstract DirectoryThursday, May 20, 2010Poster Session I — continued6:15 PM - 8:15 PMRoom: Exhibit Hall C & B-SouthMusculo-skeletal <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> I152Splice Site Strength and Nonsense-Associated Exon Skipping in theDMD <strong>Gene</strong>Kevin M. Flanigan, Diane M. Dunn, Jerry R. Mendell, Alan Pestronk, Julaine M. Florence,United Dystrophinopathy Project Consortium, Robert B. Weiss.153Long Term Antisense Treatment in Dystrophic Mouse Models forDuchenne Muscular DystrophyAnnemieke Aartsma-Rus, Christa L. de Winter, Hans A. Heemskerk, Judith C. vanDeutekom, Gert-Jan B. van Ommen.154Exon Exchange Approach To Repair Duchenne Dystrophin TranscriptsStéphanie Lorain, Cécile Peccate, Maëva Le Hir, Graziella Griffith, Thomas Voit, LuisGarcia.155Gentamicin Treatment <strong>of</strong> Duchenne Muscular Dystrophy Reinforcesthe Potential for Mutation Suppression <strong>Therapy</strong>Vinod Malik, Louise R. Rodino-Klapac, Laurence Viollet, Cheryl Wall, Wendy King,Roula Al-Dahhak, Sarah Lewis, Christopher J. Shilling, Janaiah Kota, John Hayes, JohnD. Mahan, Katherine J. Campbell, Brenda Banwell, Majed Dasouki, Victoria Watts,Kumaraswamy Sivakumar, Ricardo Bien-Willner, Kevin M. Flanigan, Zarife Sahenk,Richard J. Barohn, Christopher M. Walker, Jerry R. Mendell.156Reverse Perfusion Affords Efficient Whole-Body <strong>Gene</strong> Transfer toMuscle in the Large AnimalFrederick Balzer, Jacqueline Farag, Alock Malik, Mihail Petrov, Andrew Mead, BenjaminKozyak, Kapil Gopal, Marilyn Mitchell, Connie Choi, Jessie Chen, David Low, CharlesYarnall, Charles Bridges, Hansell Stedman.157Manganese Superoxide Dismutase Plasmid/Liposome Complex(MnSOD-PL) and Mitochondrial Targeted Nitroxide JP4-039Ameliorate Irradiation-Induced Delay in Bone Wound HealingJean-Claude Rwigema, Abhay Gokhale, Michael Epperly, Julie Glowacki, Tracy Dixon, KenPatrene, G. David Roodman, Peter Wipf, Joel Greenberger.158<strong>Gene</strong>tic Correction <strong>of</strong> Netherton Syndrome Keratinocyte Stem <strong>Cell</strong>sWaseem Qasim, Katerina Semenova, Gill Talbot, John Harper, Adrian Thrasher, FernandoLarcher, Wei Di.159Adenoviral Human Vascular Endothelial Growth Factor-D <strong>Gene</strong>Transfer Causes Angiogenesis and Growth and Enlargement <strong>of</strong>Lymphatic Vessels in Ischemic Mouse Hind LimbsGalina Dragneva, Ivana Kholová, Svetlana Laidinen, Petra Korpisalo, Pasi Tuunanen,Nina Kaskenpää, Suvi Heinonen, Felicitas Yongabi, Anna Stefanska, Varpu Marjomäki,Olli Gröhn, Seppo Ylä-Herttuala.160Validation <strong>of</strong> Intravascular Administration <strong>of</strong> Adeno-AssociatedVvirus for Muscular Dystrophies in a Non-Human Primate ModelAravind Asokan, Julia Hegge, Joshua C. Grieger, Chengwen Li, Swati Yadav, Jade J.Samulski , Xiao Xiao, Juan Li, Jon Wolff, R. Jude Samulski, Scott W. J. McPhee.Infectious Diseases and Vaccines: Vaccine Related <strong>Gene</strong>Transfer Research161Suppression <strong>of</strong> Cocaine-Induced Hyperactivity in Mice Pre-Treatedwith an Adenovirus-Based Anti-Cocaine VaccineJonathan B. Rosenberg, Martin L. Hicks, Bishnu P. De, Stephen M. Kaminsky, Amira Y.Moreno, Kim D. Janda, Stefan Worgall, Ronald G. Crystal.162Translation <strong>of</strong> Electroporation-Mediated DNA Vaccine Delivery intoa Phase I Clinical Trial Evaluating an HIV DNA Vaccine in HealthyVolunteersClaire F. Evans, Sandhya Vasan, Karen E. Dolter, Arlene Hurley, Sarah J. Schlesinger,Drew Hannaman, David F. Gardiner, Daniel P. Dugin, Yaoxing Huang, Josephine Cox,Tony Tarragona, Len Dally, Carol Smith, Claudia Schmidt, Harriet Park, Jill Gilmour,Patricia Fast, Robert Bernard, David D. Ho.163Longterm Protective Immunity Against Lethal Pulmonary Challengewith the Pseudomonas aeruginosa Following Mucosal Administration<strong>of</strong> AdC7-OprF Expressing the P. aeruginosa Protein OprFAnja Krause, Wen Zhu, Yaqin Xu, Ju Joh, Ronald G. Crystal, Stefen Worgall.164Characterization <strong>of</strong> Adenoviruses Shed from the Macaque Gut andEvaluation <strong>of</strong> Immune Responses to Adenoviruses in the Macaque inthe Context <strong>of</strong> Future Adenoviral Vaccine StudiesSoumitra Roy, Roberto Calcedo, C. Angelica Medina-Jaszek, Qiuyue Qin, JenniferMiliaresis, Surina Boyd, Diane G. Carnathan, Michael R. Betts, James M. Wilson.165A Lentiviral HIV Vaccine Candidate Elicits Long-Term Humoral and<strong>Cell</strong>ular HIV-Specific Immunity and Minimal Neutralizing ActivityBenyam Asefa, Delia Ye, Nikolay Korokhov, Laurent M. Humeau, Franck Lemiale.166Coexpressed RIG-I Agonist Enhances Humoral Immune Response toInfluenza DNA VaccineJeremy M. Luke, Clague P. Hodgson, James A. Williams.Thursday, May 20 th
96<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectoryThursday, May 20 thThursday, May 20, 2010Poster Session I — continued6:15 PM - 8:15 PMRoom: Exhibit Hall C & B-SouthInfectious Diseases and Vaccines: Vaccine Related <strong>Gene</strong>Transfer Research167<strong>Gene</strong>tically Engineered Bifidobacterium Displaying Salmonella-AntigenProtects Mice from Lethal Challenge <strong>of</strong> Salmonella Typhimurium in aMurine Typhoid Fever ModelToshiro Shirakawa, Sakura Yamamoto, Jun Wada, Takane Katayama, Takumi Jikimoto,Masakuni Nakamura, Shohiro Kinoshita, Kyung-Mi Lee, Masato Kawabata.168Signaling Lymphocytic Activation Molecule (SLAM, CD150)-BlindMeasles Virus Is Attenuated and Induces Strong Adaptive ImmuneResponses in Rhesus MonkeysVincent Leonard, Gregory Hodge, Jorge Reyes-del Valle, Michael McChesney, RobertoCattaneo.169Evaluation <strong>of</strong> Mismatched Immunity To Expand Cross-ProtectionAgainst Influenza VirusAmi Patel, Isabelle Meunier, Kaylie N. Tran, Anders Leung, Stephane Pillet, DarwynKobasa, Veronika von Messling, Gary P. Kobinger.170Immune Response Against Measles Virus Encoding Helicobacter pyloriNeutrophil-Activating Protein AntigenIanko D. Iankov, Iana Haralambieva, Evanthia Galanis.171<strong>Gene</strong>ration <strong>of</strong> Chimeric GB Virus B Clones Encoding the Hepatitis CVirus E1E2p7 and coreE1E2p7 toward the Infected Marmoset ModelsTingting Li, Lifang Shuai, Zixuan Chen, Anqi Wang, Wenjing Wang, Chengyao Li.172Characterization <strong>of</strong> Immune Response in Mice Induced byRecombinant Vaccinia Virus (Tiantan) Based Multivalent H5N1 AvianInfluenza VaccinesWen Wang, Yao Deng, Wenjie Tan, Hong Chen, Li Ruan, Yuelong Shu.173The Effects <strong>of</strong> the Calreticulin on the Immune Response Induced byDNA Vaccine Containing the Classical Swine Fever Virus E2 <strong>Gene</strong> inMouse ModelMing Kun Hsieh, Chia Chin You, Chienjin Huang.174Evaluation <strong>of</strong> the Multi-Electrode Array for Use in DNA VaccinationAgainst Bacillus anthracisAmy L. Donate, Richard Heller.Cancer – Immunotherapy I175Enhancing the Priming <strong>of</strong> Tumor Antigen Specific T <strong>Cell</strong> ResponsesUsing Oncolytic VirusesPhonphimon Wongthida, Rosa Diaz, Feorillo Galivo, Karen Kaluza, Jill Thompson,Timothy Kottke, Richard Vile.176AdCD40L Immunogene <strong>Therapy</strong> for Bladder Carcinoma – A Phase I/IIa TrialPer-Uno Malmstrom, Angelica S. I. Loskog, Camilla A. Lindqvist, Sara M. Mangsbo, MoaFransson, Alkwin Wanders, Truls Gardmark, Thomas H. Totterman.177Treatment <strong>of</strong> Refractory Cancer Patients with a Serotype 5/3Chimeric Oncolytic Adenovirus Expressing Granulocyte MacrophageColony-Stimulating Factor (GM-CSF): Virological, Immunological andClinical EndpointsAnniina Koski, Sari Pesonen, Vincenzo Cerullo, Sophie Escutenaire, Elina Haavisto, LottaKangasniemi, Pekka Simula, Timo Joensuu, Akseli Hemminki.178IL-15 Reduces Suppressive Effects <strong>of</strong> Regulatory T <strong>Cell</strong>s (Tregs) onAntigen-Specific Cytotoxic T Lymphocytes (CTLs)S. Perna, B. De Angelis, D. Pagliara, L. Zhang, C. Rooney, H. Heslop, M. Brenner, G.Dotti, B. Savoldo.179PiggyBac Transposon Modified EBV Specific Human T Lymphocytesfor HER2-Positive <strong>Cell</strong>ular Immunotherapy In VivoYozo Nakazawa, Nabil Ahmed, Vita Salsman, Ann Leen, Stephen Gottschalk, MatthewH. Wilson, Cliona M. Rooney.180Adenovirus-Mediated Intratumoral Expression <strong>of</strong> ImmunostimulatoryMolecules Together with Systemic Depletion <strong>of</strong> Regulatory T-<strong>Cell</strong>sInduces Tumor-Destructive Immune Responses in Mouse ModelsYing Liu, Jonas Persson, Sebastian Tuve, Roma Yumul, ZongYi Li, Steve R<strong>of</strong>fler, AndreLieber.181Key Role <strong>of</strong> B <strong>Cell</strong> as Antigen Presenting <strong>Cell</strong>s in the Anti-TumorImmunity Induced by a Combined Immune-Stimulatory/ConditionalCytotoxic <strong>Therapy</strong> for GlioblastomaMarianela Candolfi, Kader Yagiz, James F. Curtin, Hikmat Assi, Mia Wibowo, GabrielleAlzadeh, David Foulad, Kurt Kroeger, Anderson Alden, Chunyan Liu, Robert Dunn, PedroR. Lowenstein, Maria G. Castro.182<strong>Gene</strong>tically Engineered Malignant Glioma-Specific T <strong>Cell</strong>s Resistant toGlucocorticoidsSeogkyoung Kong, Richard P. Junghans, Prakash Sampath.183Adoptive Transfer <strong>of</strong> T <strong>Cell</strong>s <strong>Gene</strong>tically Targeted to the MUC16Antigen Eradicates Established Peritoneal Ovarian Tumors in SCID-Beige MiceAlena A. Chekmasova, Thapi D. Rao, David R. Spriggs, Renier J. Brentjens.EXHIBITOR PROSPECTUSfinal program
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