13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010 97Abstract DirectoryThursday, May 20, 2010Poster Session I — continued6:15 PM - 8:15 PMRoom: Exhibit Hall C & B-SouthCancer – Immunotherapy I184Adoptive Transfer <strong>of</strong> Autologous T <strong>Cell</strong>s Targeted to Prostate SpecificMembrane Antigen (PSMA) for the Treatment <strong>of</strong> Castrate MetastaticProstate CancerOriana Borquez-Ojeda, Jolanta Stefanski, Xiuyan Wang, Jason Plotkin, Jinrong Qu,Luis Rodriguez, Elliot Servais, Kei Suzuki, Larrisa Shenker, Vladimir Ponomarev, SusanSlovin, Michel Sadelain, Isabelle Rivière.185A New Human-Derived Reporter <strong>Gene</strong> Suitable for Clinical PETImaging <strong>of</strong> T-<strong>Cell</strong> TraffickingYury Likar, Juan Zurita, Larissa Shenker, Maxim Moroz, Shangde Cai, Anton Neschadim,Jeffrey Medin, Hedvig Hricak, Michel Sadelain, Vladimir Ponomarev.186Inhibition <strong>of</strong> Mice Colon Tumor Growth by Il-15 Immunogene <strong>Therapy</strong>Xianghui He, Weidong Li, Yifeng Wang, Linan Hou, Liwei Zhu.187Development <strong>of</strong> High-Performance HVJ-E for Cancer Immune <strong>Therapy</strong>Kotaro Saga, Katsuto Tamai, Takehiko Yamazaki, Yasufumi Kaneda.188Combined <strong>Gene</strong> <strong>Therapy</strong> Using Adenovirus Expressing Interleukin-12,Granulocyte-Macrophage Colony-Stimulating Factor, and ThymidineKinase with Prodrug GanciclovirJi-seong Kim, Kyoung-ju Choi, Chae-Ok Yun.189Safety Data <strong>of</strong> MGN1601, a Tumor Vaccine, Made <strong>of</strong> Allogeneic,Transfected and Irradiated Tumor <strong>Cell</strong>s in Combination with anImmunomodulator for the Treatment <strong>of</strong> Metastatic Renal <strong>Cell</strong>CarcinomaManuel Schmidt, Baerbel Volz, Matthias Schr<strong>of</strong>f, Kerstin Kapp, Christiane Kleuss, MarinaTschaika, Burghardt Wittig.190Development <strong>of</strong> an HLA-A*0201 Restricted T <strong>Cell</strong> Receptor ThatRecognizes Peptide Epitopes from MAGE-A3 and MAGE-A12 forTargeted Adoptive T <strong>Cell</strong> Immunotherapy <strong>of</strong> Multiple Cancer TypesNachimuthu Chinnasamy, Jennifer A. Wargo, Zhiya Yu, Timothy L. Frankel, John P. Riley,Maria R. Parkhurst, Steven A. Feldman, Nicholas P. Restifo, Paul F. Robbins, Steven A.Rosenberg, Richard A. Morgan.Cancer-Oncolytic Viruses I191 (Moved to Oral Abstract Session 413)A Comparative Study <strong>of</strong> Stem <strong>Cell</strong>-Based <strong>Cell</strong> Carrier Systems for theSystemic Delivery <strong>of</strong> an Oncolytic Adenovirus for Antiglioma <strong>Therapy</strong>Matthew A. Tayler, Atique U. Ahmed, Ilya V. Ulasov, Irina Y. Balyasnikova, Maciej S.Lesniak.192A Novel Coxsackievirus B Shows Remarkable Oncolytic CapacityAgainst Lung CancerShohei Miyamoto, Hiroyuki Inoue, Meiko Yamada, Xin Meng, Takafumi Nakamura,Yasuo Urata, Hiroyuki Shimizu, Kenzaburo Tani.193Preclinical and Clinical Data with a Fully Serotype 3 OncolyticAdenovirus Ad3-hTERT-E1A in the Treatment <strong>of</strong> Advanced SolidTumorsOtto Hemminki, Gerd Bauerschmitz, Silvio Hemmi, Sergio Lavilla-Alonso, Iulia Diaconu,Anna Kanerva, Vincenzo Cerullo, Minna Oksanen, Elina Haavisto, Timo Joensuu, SariPesonen, Akseli Hemminki.194Mechanism <strong>of</strong> Tumour Penetration by Oncolytic Viruses –Investigation in a 3 Dimensional In Vitro ModelC. A. Campion, C. Harty, G. C. O’Sullivan, J. K. Collins.195Mechanisms <strong>of</strong> Cyclophophamide Enhancing Anti-Tumor Effects <strong>of</strong>Oncolytic Vesicular Stomatitis Virus for Breast Cancer TreatmentHongxun Wang, Stephen Russell, Jian Qiao.196Clinical Characterization <strong>of</strong> the Adenovirus Death Protein-PotentiatedOncolytic Adenovirus VRX007Alex W. Tong, Anagha P. Phadke, Staci Horvath, William Wold, John Nemunaitis, NeilSenzer.197Safety and Immunological Effects <strong>of</strong> Corticosteroids in PatientsTreated with Oncolytic AdenovirusesMaria Rajecki, Mari Raki, Andreas Helminen, Sophie Escutenaire, Sari Pesonen, VincenzoCerullo, Timo Joensuu, Elina Haavisto, Laura Ahtiainen, Akseli Hemminki.198Effect <strong>of</strong> Decorin on Overcoming the Extracellular Matrix Barrier forOncolytic VirotherapyIl-Kyu Choi, Young-Sook Lee, Ji Young Yoo, A-Rum Yoon, Hye Jin Choi, Daniela G. Seidler,Chae-Ok Yun.199Chondroitinase ABC1 Mediated Enhancement <strong>of</strong> OV Spread andEfficacyNina Dmitrieva, Mariano Viapiano, Balveen Kaur.200Use <strong>of</strong> PET Imaging for In-Vivo Monitoring <strong>of</strong> Replication CompetentRetrovirus (RCR) Transduction <strong>of</strong> Malignant GliomasWeijun Wang, Hui Wang, Ryan Park, Hancheng Cai, Peter S. Conti, Nori Kasahara,Thomas C. Chen.Thursday, May 20 th
98<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectoryThursday, May 20 thThursday, May 20, 2010Poster Session I — continued6:15 PM - 8:15 PMRoom: Exhibit Hall C & B-SouthCancer-Oncolytic Viruses I201Systemic Cancer Screening Using an Oncolytic HSV To Induce Tumor-Selective Expression <strong>of</strong> a Secretable Serum BiomarkerAndrew W. Browne, Jennifer L. Leddon, Mark A. Currier, Jon P. Williams, Nancy Ratner,Timothy P. Cripe.202Therapeutic and Tumor-Specific Immunity Induced by Combination<strong>of</strong> Dendritic <strong>Cell</strong>s and Oncolytic Adenovirus Expressing IL-12 and4-1BBLSong-Nan Zhang, Jing-Hua Huang, Joo-Hang Kim, Kyung-Ju Choi, Il-Kyu Choi, MingulLee, Chae-Ok Yun.203Oncolytic Herpes Simplex Virus Encoding Interferon b <strong>Gene</strong> forSquamous <strong>Cell</strong> Carcinoma <strong>of</strong> the Head and NeckHongtao Li, Stephen J. Russell.204Targeted Suicide <strong>Gene</strong> <strong>Therapy</strong> with Oncolytic AdenovirusCoding for FCU1, a Fusion Protein <strong>of</strong> Cytosine Deaminase andUracilphosphoribosyltransferaseJoão D. Dias, Ilkka Liikanen, Kilian Guse, Johann Foloppe, Marta Sloniecka, Iulia Diaconu,Ville Rantanen, Minna Eriksson, Tanja Hakkarainen, Monika Lusky, Philippe Erbs, SophieEscutenaire, Anna Kanerva, Sari Pesonen, Vincenzo Cerullo, Akseli Hemminki.Cancer-Targeted <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> I205Controlled Nuclear Localization <strong>of</strong> p53 in Breast Cancer <strong>Cell</strong>sMohanad Mossalam, Carol S. Lim.206Effect <strong>of</strong> Transcriptionally Targeted Suicide <strong>Gene</strong> <strong>Therapy</strong> for Small<strong>Cell</strong> Lung Cancer In Vitro and In Vivo by DOTAP/Cholesterol- andAdenoviral-Mediated DeliveryCamilla L. Christensen, Torben Gjetting, Frederik Cramer, Skovgaard Hans.207NF-kB Activity Regulates MSC Accumulation at Tumor SitesRyosuke Uchibori, Hiroyuki Mizuguchi, Tomonori Tsukahara, Masashi Urabe, HiroakiMizukami, Akihiro Kume, Keiya Ozawa.208Dynamics <strong>of</strong> <strong>Therapy</strong> <strong>of</strong> Malignant Melanoma with VesicularStomatitis VirusJyoti Dev, Chetan P. Offord, Diana M. Rommelfanger, Richard G. Vile, Zeljko Bajzer,David Dingli.209Therapeutic Efficacy <strong>of</strong> a Lentiviral Mediated Thymidine Kinase/Ganciclovir Treatment in an Immunocompetent Rat Malignant GliomaModelJere T. Pikkarainen, Hanna P. Lesch, Haritha Samaranayake, Minna U. Kaikkonen, Ann-Marie Määttä, Seppo Ylä-Herttuala.210Insertion <strong>of</strong> Transcription Factor Nuclear Factor Kappa B Binding Sitesinto Plasmid DNA Expressing a Suicide <strong>Gene</strong> Facilitates IncreasedSmall <strong>Cell</strong> Lung Cancer <strong>Cell</strong> Death In Vitro Due to Increased NuclearUptakeFrederik Cramer, Camilla L. Christensen, Hans S. Poulsen.211Preirradition <strong>Gene</strong> <strong>Therapy</strong> Against Transforming Growth Factor-bSignal Is Radioprotective for the LiverZhao-Chong Zeng, Shi-Suo Du, Ming Qiang, Zheng-Yu Zhang.212Rabbit VX-2 Brain Tumor Model for Development <strong>of</strong> Improved VectorAdministration TechniquesFarizan Ahmad, Agnieszka Pacholska, Anna Hyvärinen, Venla Tuppurainen, ThomasWirth, Seppo Ylä-Herttuala.213Nano-Flow 2D-HPLC MALDI-TOF MS/MS for Differentially ExpressedProtein Analysis in Breast Cancer Patient SamplesCourtney Haddock, R. B. Holtz, Neil Senzer, Phillip B. Maples, John Nemunaitis.214In Vitro Characterization for In Vivo Translation <strong>of</strong> a Novel Non-Viral<strong>Gene</strong> Delivery VectorLuke J. Higgins, Gloria L. Hwang, Regina H. Katzenberg, Nishita Kothary, Daniel Y. Sze,Lawrence V. H<strong>of</strong>mann.215Altering the Tropism <strong>of</strong> Herpesvirus saimiri to Selectively InfectHepatocellular Carcinoma (HCC) <strong>Cell</strong>sSusan Turrell, Adrian Whitehouse.216Improved <strong>Gene</strong> Transfer into Renal Carcinoma <strong>Cell</strong>s Using anAdenovirus VectorShuji Terao, Bishnu Acharya, Toru Suzuki, Katsuyuki Hamada, Hiroyuki Mizuguchi,Akinobu Gotoh.217Prostate Cancer <strong>Gene</strong> <strong>Therapy</strong> Using Adenovirus Expressing a NovelApoptosis-Inducing <strong>Gene</strong> and Its Conjugation with ChemotherapyXiongwen Zhang, Ben Beheshti, Yi Lu.218Development and Preclinical Testing <strong>of</strong> Large Batches <strong>of</strong> SNS01-A– An eIF5A-Based <strong>Gene</strong> <strong>Therapy</strong> Nanoparticle Designed for theTreatment <strong>of</strong> Multiple MyelomaCatherine A. Taylor, Zhongda Liu, Terence Tang, Bin Ye, Bruce Galton, Kathleen A.Donovan, John A. Lust, John E. Thompson, Richard Dondero.EXHIBITOR PROSPECTUSfinal program
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