13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010 91Abstract DirectoryThursday, May 20, 2010Poster Session I — continued6:15 PM - 8:15 PMRoom: Exhibit Hall C & B-SouthAdenovirus and Other DNA Virus Vectors I79Interaction between Adenoviral Vector-Transduced Dendritic <strong>Cell</strong>-Based Cancer Vaccine and T Regulatory or T Helper 17 <strong>Cell</strong>sAdele Y. Wang, Sarah Q. Crome, Kristy M. Jenkins, Jeffrey A. Medin, Jonathan L.Bramson, Megan K. Levings.80Replicating Adenoviruses That Harbors the ADP Protein and theSodium Iodide Symporter Protein (NIS) under the Control <strong>of</strong> theMajor Late Adenovirus PromoterMiguel A. Trujillo, Julia Davydova, Michael J. Oneal, Samantha McDonough, MasatoYamamoto, John C. Morris.81FX Domain Fused to Single-Chain Antibodies Improve Oncolytic Effect<strong>of</strong> Ad5 In Vitro and In VivoChristopher Y. Chen, Michael A. Barry.82Sustained Inhibition <strong>of</strong> Hepatitis B Virus Replication In Vivo UsingHelper-Dependent Adenovirus VectorsCarol Crowther, Betty Mowa, Felix Salazar, Patricia Marion, Abdullah Ely, PatrickArbuthnot.83Adenovirus Serotype 5/35 Is Excellent for <strong>Gene</strong>tic Engineering <strong>of</strong>Tumor-Directed T <strong>Cell</strong>sHannah Karlsson, Camilla Lindqvist, Bengt Simonsson, Ulla Olsson-Strömberg, AngelicaS. I. Loskog.84Bipartite Adenoviral Vector Encoding hHGF and hXIAP for ImprovedHuman Islet TransplantationHao Wu, A-Rum Yoon, Chae-Ok Yun, Ram I. Mahato.85Vector Prime-Protein Boost Vaccine for Patients with <strong>Therapy</strong>Induced LymphopeniaTae Hee Han, Yucheng Tang, Yeon Hee Park, Pingchuan Li, Hakan Akbulut, Line Petersen,Jonathan Maynard, Albert Deisseroth.86The Effect <strong>of</strong> Surface Modification <strong>of</strong> Adenovirus with an Arginine-Grafted Bioreducible Polymer on Transduction Efficiency andImmunogenicity in Cancer <strong>Gene</strong> <strong>Therapy</strong>Pyung-Hwan Kim, Tae-il Kim, James W. Yockman, Sung Wan Kim, Chae-Ok Yun.Targeting <strong>Gene</strong> Modification and Integration87Safe and Efficient Delivery <strong>of</strong> Meganucleases for Lentivirus-Mediated<strong>Gene</strong> TargetingAraksya Izmiryan, Alix Bourdel, Arnaud Jollet, Frédéric Pâques, Olivier Danos.88Site-Specific Genome Modification <strong>of</strong> Human Primary T LymphocytesTo Improve the Safety and Efficacy <strong>of</strong> Adoptive ImmunotherapyPietro Genovese, Elena Provasi, Angelo Lombardo, Zulma Magnani, Andreas Reik, Pei-QiLiu, Oscar Muniz Pello, Jurgen Kuball, Philip D. Gregory, Michael C. Holmes, Philip D.Greenberg, Chiara Bonini, Luigi Naldini.89Single-Strand Nicks Induce Homologous Recombination with LessToxicity Than Double-Strand Breaks Using an AAV TemplateMichael J. Metzger, Audrey McConnell-Smith, Barry L. Stoddard, A. Dusty Miller.90Targeted <strong>Gene</strong> Insertion in Human Chromosomes Using a HomingEndonucleaseByoung Y. Ryu, Michael T. Certo, Mikhail Garibov, Andrew M. Scharenberg, David J.Rawlings.91<strong>Cell</strong> Synchronization by Serum Shock Facilitates rAAV-Mediated <strong>Gene</strong>TargetingYonglun Luo, Emil K<strong>of</strong>od-Olsen, Jenny Blechingberg, Rikke Christensen, Nicklas HeineStaunstrup, Lars Bolund, Charlotte Brandt Sørensen.92Critical Amino Acid Residues within the PhiC31 Integrase DNABinding Domain Affect Recombination Activities in Mammalian <strong>Cell</strong>sRaphael Liesner, Wenli Zhang, Nadja Noske, Anja Ehrhardt.93Chromatin Structure <strong>of</strong> Two Genomic Sites for Targeted TransgeneIntegration in Induced Pluripotent Stem <strong>Cell</strong>sRuan van Rensburg, Oleg Denisenko, Karol Bomsztyk, Andre Lieber.94Targeted Plasmid Integration into the PiggyBac Transposon by anEngineered Zinc Finger RecombinaseCharles A. Gersbach, Russell M. Gordley, Thom Gaj, Andrew C. Mercer, Carlos F. Barbas,III.95Development <strong>of</strong> Autonomously Working Zinc-Finger Nuclease Pairsfor Targeted Genome EngineeringCem Söllü, Kaweh Montazami-Astaneh, Morgan L. Maeder, Stacey Thibodeau-Beganny,J. Keith Joung, Toni Cathomen.96Adeno-Associated Virus-2 (AVV2) Integrase Mediates SpecificIntegration to Locus AAVS1 on Chromosome 19q13.3 in aHematopoietic <strong>Cell</strong> LineAshley E. Dunfee, Joshua R. Clevenger, Cynthia E. Dunbar, Andre Larochelle.Thursday, May 20 th
92<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectoryThursday, May 20 thThursday, May 20, 2010Poster Session I — continued6:15 PM - 8:15 PMRoom: Exhibit Hall C & B-SouthTargeting <strong>Gene</strong> Modification and Integration97<strong>Gene</strong> Correction in Mouse LiverHiroyuki Kamiya, Masayuki Uchiyama, Jingshu Piao, Yoshimichi Nakatsu, TeruhisaTsuzuki, Hideyoshi Harashima.98A Transient Cold Shock Enhances Zinc-Finger Nuclease-Mediated <strong>Gene</strong>DisruptionYannick Doyon, Vivian M. Choi, Danny Xia, Thuy D. Vo, Michael C. Holmes, Philip D.Gregory.99Single-Polarity rAAV May Enhance Hepatic <strong>Gene</strong> Targeting In VivoNicole K. Paulk, Markus Grompe.Physical Methods <strong>of</strong> Delivery100Over-Expression <strong>of</strong> Adiponectin and Adiponectin Receptor 2 <strong>Gene</strong> bythe Method <strong>of</strong> Hydrodynamic <strong>Gene</strong> Delivery Prevents Weight Gainand Development <strong>of</strong> Insulin Resistance in AKR/J MiceYongjie Ma, Dexi Liu.101Duration <strong>of</strong> Expression after <strong>Gene</strong> Electrotransfer to Skin Depends onthe <strong>Gene</strong> <strong>of</strong> InterestAnita Gothelf, Jens Eriksen, Pernille Hojman, Julie Gehl.102Intravenous Delivery <strong>of</strong> pDNA and siRNA into Muscle by Ultrasound-Mediated Bubble LiposomesYoichi Negishi, Yoko E. Takahashi, Yuko Ishii, Ryo Suzuki, Kazuo Maruyama, YukihikoAramaki.103Prototype Development and Pre-Clinical Immunogenicity Analysis <strong>of</strong>a Novel Minimally Invasive Electroporation DeviceKate E. Broderick, Jay McCoy, Xuefei Shen, Feng Lin, Amir Khan, Matthew Morrow,Stephen Kemmerrer, David B. Weiner, Niranjan Y. Sardesai.104Ultrasound-Assisted Non-Viral <strong>Gene</strong> Transfer to the Salivary GlandsMichael J. Passineau, Lee Zourelias, Laurie Machen, Paul C. Edwards, Raymond L. Benza.105Development <strong>of</strong> Electroporation Formulation for <strong>Cell</strong> <strong>Therapy</strong>Mike Flanagan, Gang Yu, Jeffry Gimble, Shulin Li.106Ca 2+ Electrotransfer; a Quick Stop Procedure Against TransgenicExpressionPernille Hojman, Iben Spanggaard, Julie Gehl, Hanne Gissel.107In Vivo <strong>Gene</strong> Delivery to the Skin by Electroporation Using a MultipleElectrode ArraySiqi Guo, Amy Donate, Gaurav Basu, Kathryn Lundberg, Richard Heller.108Hydrodynamic <strong>Gene</strong> Delivery Efficiency Is Reduced in Fibrotic Liver inRatsTian Zhou, Dexi Liu.109Efficiency <strong>of</strong> Electroporation Delivery <strong>of</strong> Peptide Nucleic Acid (PNA)Depends on PNA Charge and Electrotransfer ProtocolMette Joergensen, Birgit Agerholm-Larsen, Peter E. Nielsen, Julie Gehl.110Biodistribution <strong>of</strong> Plasmid AMEP, a Potent Antitumor <strong>Gene</strong> Productfor the Treatment <strong>of</strong> Metastatic MelanomasCeline Bouquet, Elisabeth Dam, Veronique Trochon-Joseph, Valerie Polard, VincentSainte-Catherine, Emilienne Soma, Sophie Lebel-Binay.111In Vivo Intracellular Injection Needle (IvIn) Technology: A NewNeedle for Improved <strong>Cell</strong>ular Uptake <strong>of</strong> DNA in a Live AnimalLars Frelin, Gustaf Ahlén, Matti Sällberg.112A Study on Techniques for Safety Assessment <strong>of</strong> <strong>Gene</strong> <strong>Therapy</strong>Products Using ElectroporationMin Joung Choi, Il Ung Oh, Sung Yeol Han, Oh Seok Kwon, Seung Hwa Hong.113Toxicology and Safety Studies <strong>of</strong> Plasmid AMEP, a New EfficientAntitumor <strong>Gene</strong> Product for the Treatment <strong>of</strong> Metastatic MelanomasCeline Bouquet, Veronique Trochon-Joseph, Valerie Polard, Vincent Sainte-Catherine,Emilienne Soma, Sophie Lebel-Binay.114Enhancement <strong>of</strong> the Immune Response <strong>of</strong> a Noval DNA VaccineEncoding Conserved NS3 and Core Fusion <strong>Gene</strong> <strong>of</strong> HCV Injected byIntradermal Electrotransfer in MiceXiao Yin, Jian Lu, Wenjie Tan, Jie Guan, Li Ruan.115Electroporation-Enhanced DNA Prime/Protein Boost Strategy ToImprove Cross-Clade Immunogenicity <strong>of</strong> HIV-1 Envelope AntigenKate E. Broderick, K. Muthumani, Xuefei Shen, Jian Yan, Feng Lin, Janess Mendoza,Amir Khan, Niranjan Y. Sardesai, David B. Weiner.116Effectiveness <strong>of</strong> Impedance Spectroscopy To Monitor Impact <strong>of</strong> anElectroporation Protocol on TissueJ. Anthony Llewellyn, Loree Heller, Richard A. Gilbert.EXHIBITOR PROSPECTUSfinal program
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