13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010139Abstract DirectorySaturday, May 22, 2010Poster Session III — continued6:00 PM - 8:00 PMRoom: Exhibit Hall CHematologic and Immunologic <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> III862Prevention <strong>of</strong> Atopic Dermatitis by Plasmid-Based SustainedTransgene Expression <strong>of</strong> Interferon g in NC/NGA MiceKayoko Hattori, Makiya Nishikawa, Kanitta Watcharanurak, Akihiko Ikoma, KenjiKabashima, Hiroyasu Toyota, Yuki Takahashi, Rei Takahashi, Yoshihiko Watanabe,Yoshinobu Takakura.863Expression <strong>of</strong> an Antibody Against CTLA4 from Tumor InfiltratingLeukocytes Induces Efficient Anti-Tumor Immune Responses in aMouse Model for Breast CancerJonas Persson, Ying Liu, Roma Yumul, ZongYi Li, Steve R<strong>of</strong>fler, Andre Lieber.864Foamy Virus Vectors with MGMT-P140K Mediate Efficient Selectionin a Canine Pyruvate Kinase Deficiency Model for HematopoieticStem <strong>Cell</strong> <strong>Gene</strong> <strong>Therapy</strong>Brian C. Beard, Robert A. Wu, Christina Ironside, Punam Malik, Kiem Hans-Peter,Trobridge D. Grant.865Modeling <strong>of</strong> Congenital Erythropoietic Porphyria by RNA-Interference: A New Tool for Preclinical <strong>Gene</strong> <strong>Therapy</strong> EvaluationHubert de Verneuil, Elodie Robert-Richard, Magalie Lalanne, Isabelle Lamrissi-Garcia,Véronique Guyonnet-Duperat, Emmanuel Richard, Frédéric Mazurier, Cécile Ged, FrançoisMoreau-Gaudry.866<strong>Gene</strong> Corrected Neutrophils from Induced Pluripotent Stem <strong>Cell</strong>sDerived from an X-CGD Disease ModelSayandip Mukherjee, Giorgia Santilli, Michael P. Blundell, Elena Almarza, Juan Bueren,Adrian J. Thrasher.867The Comparison <strong>of</strong> Various Promoters for Wiskott Aldrich Syndrome<strong>Gene</strong> <strong>Therapy</strong> Using Insulated Lentiviral VectorsRachel M. Koldej, Deepti Banka, Gael Carney, Hui Fen Zhao, Derek Persons, Arthur W.Nienhuis.868Sleeping Beauty-Mediated Therapeutic <strong>Gene</strong> Transfer intoHematopoietic Stem <strong>Cell</strong>sKendra A. Hyland, Erik R. Olson, Xianzheng Zhou, R. Scott McIvor.869 (Moved to Poster Session I after Abstract 233)Myelospecific Self-Inactivating Gammaretroviral Vectors for p47 phoxCGD <strong>Gene</strong> <strong>Therapy</strong>Vital Wohlgensinger, Christian Brendel, Axel Schambach, Manuel Grez, JanineReichenbach, Reinhard A. Seger, Ulrich Siler.870Delivery <strong>of</strong> Soluble ICAM-1 in NOD Salivary Glands Can Result in B<strong>Cell</strong> Proliferation and Immunoglobulin ProductionJelle L. Vosters, Nienke Roescher, Paul P. Tak, John A. Chiorini.871Modulation <strong>of</strong> CXCR4 Expression by Novel Growth Factor Cocktail onStem <strong>Cell</strong>sSomayeh Shahrokhi, Kamran Alimoghaddam, Massoumeh Ebtekar, Zohre Sharifi,Seyed Hamidolah Ghaffari, Ali Akbar Pourfathollah, Mahboobeh Mohseni, ArdeshirGhavamzadeh.Lung and Respiratory Disease <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>872Efficient <strong>Gene</strong> Delivery to Pig Airways Using Helper-DependentAdenoviral VectorsHuibi Cao, Jonathan C. Yeung, Cathleen Duan, Allan Coates, Kitty Leung, Shaf Keshavjee,Jim Hu.873SIV Vector Pseudotyped with SeV-F/HN Envelope Proteins ProducesLong Lasting Expression in the Murine Lung, Is Readministrable andTransfects Human Airway ModelsUta Griesenbach, Makoto Inoue, Cuixiang Meng, Andrea M. Brum, Raymond Farley,Nikki Newman, Eiji Akiba, Mamoru Hasegawa, Eric W. F. W. Alton.874Airway Lentiviral <strong>Gene</strong> Transfer In MarmosetsDavid Parsons, Richard Bright, Darren Miller, Don Anson.875Pulmonary Delivery <strong>of</strong> mRNA: In Vitro and In Vivo EvaluationOliwia Najder, Joanna Rejman, Stefaan De Smedt, Joseph Demeester, Mario VanPoucke, Luc Peelman, Niek N. Sanders.876Inhibiting Bap31 by Dominant Negative p20 Does Not Promote CFTRTranslocation to the <strong>Cell</strong> MembraneYadong Zhang, Wei Zhang, Min Li, T. C. Hwang, Yihong Ye, Dongsheng Duan.877Targeted siRNA Delivery to Lung Epithelia Reduces Mucus Secretionin a Mouse Model for Allergic AsthmaHyo Sung Choi, Jae Wook Jung, Hong Seok Ban, Nahyun Kim, Priti Kumar, Sang kyungLee.878The T1a Promoter Mediates Nuclear Import <strong>of</strong> Plasmid DNA intoAlveolar Epithelial Type I <strong>Cell</strong>sLynn F. Gottfried, David A. Dean.Saturday, May 22 nd
140<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectorySaturday, May 22 ndSaturday, May 22, 2010Poster Session III — continued6:00 PM - 8:00 PMRoom: Exhibit Hall CLung and Respiratory Disease <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>879Effects <strong>of</strong> LPC on Lung Mechanics in Non-Human PrimatesP. Hiatt, R. McConnell, N. Grove, D. Dang, N. Brunetti-Pierri, D. Palmer, A. Beaudet, P.Ng.880Repeat Aerosol Delivery <strong>of</strong> Concentrated PEI/pDNA to the SheepLungGerry McLachlan, Lee A. Davies, Cath M. Gordon, Christina Vrettou, Eilidh Baker, PeterTennant, Alison Baker, Rebecca L. Coles, Dominique McCormick, Stephanie G. Sumner-Jones, Stephen C. Hyde, Deborah R. Gill, D. David S. Collie.881Pseudotype Switching as a Strategy To Permit Efficient Re-Administration <strong>of</strong> Lentiviral Vectors to Mouse AirwaysJohn C. Olsen, Angela Giddings, Manij Patel.Oligonucleotide & RNAi Therapeutics III882Antinociceptive Potentiation and Attenuation <strong>of</strong> Tolerance byIntrathecal b-Arrestin 2 siRNA in RatsChung-Ren Lin, Kuan-Hung Chen, Chih-Hsien Wu, Yi-Sen Chen.883siRNA Cationic Delivery Systems for Therapeutic ApplicationsAnne-Laure D. Bolcato-Bellemin, Marie-Elise Bonnet, Gaëlle Deglane, Nathalie Lenne,Patrick Neuberg, Clément Paris, Jean-Paul Behr, Patrick Erbacher.884Therapeutic Effect <strong>of</strong> Intravenous Administration <strong>of</strong> New Type HybridStaple-Modified NFkB Decoy Oligonucleotides on InflammatoryBowel Disease Model MiceKazunari Ozaki, Hir<strong>of</strong>umi Makino, Takashi Miyake, Yasushi Takeya, Motokuni Aoki,Hiromi Rakugi, Ryuichi Morishita.885Artificial miRNA Clusters for Targeting Multiple Regions <strong>of</strong> the HCVGenomeXiao Yang, Virginia Haurigot, Shangzhen Zhou, Linda B. Couto.886Design and Pre-Clinical Evaluation <strong>of</strong> Adeno-Associated Viral (AAV)Vectors for Therapeutic Inhibition <strong>of</strong> Disease-Associated miRNAsNina Schürmann, Ellen H<strong>of</strong>fmann, Dirk Grimm.887Safety Results <strong>of</strong> a Phase 1 Clinical Study for Treatment <strong>of</strong> Patientswith Advanced Solid Tumors with the TLR9 Agonist MGN1703Max E. Scheulen, Manuel Schmidt, Michael S. von Bergwelt-Baildon, Ulrich Hacker,Alexander Shimabukuro-Vornhagen, Heike Richly, Bahar Nokay, Marina Tschaika,Burghardt Wittig, Martin R. Weihrauch.888Parallel Assessment <strong>of</strong> Silencing Potency <strong>of</strong> Conventional SiRNAs vs.SiRNA VariantsNicholas M. Snead, Min-sun Song, Kumi Sakurai, John J. Rossi.889Inhibition <strong>of</strong> Viral Hepatitis with Non-Coding RNAsJovanna Gonzalez-Rojas, Amaya Abad, Lorea Blazquez, Nerea Razquin, Xabier Abad,Puri Fortes.890Screening <strong>of</strong> Nature Compounds for Enhancing AntisenseOligonucleotide-Induced Exon Skipping <strong>of</strong> Dystrophin <strong>Gene</strong> In Vitroand In VivoBo Wu, Caryn Cloer, Peijuan Lu, Mingxing Wang, Wei Li, Kazuo Koike, Qi Long Lu.891A Combination <strong>of</strong> PHD2 Prolyl Hydroxylase Silencing andBiocompatible Polyplex Nanocarrier Enhances TherapeuticAngiogenesisShourong Wu, Nobuhiro Nishiyama, Keiji Itaka, Takuya Hashimoto, Hiroyuki Koyama,Mitsunobu R Kano, Kazunori Kataoka.892Development <strong>of</strong> a Novel, RNAi-Based Therapeutic TargetingPancreatic Duodenal Homebox-1 (PDX-1) for Insulinoma andPancreatic CancerZhaohui Wang, Shi-he Liu, Donald D. Rao, Phillip B. Maples, Neil Senzer, JohnNemunaitis, F. C. Brunicardi.893Systemic Delivery <strong>of</strong> Highly Active Functionalized Lipopolyamine-Formulated siRNA to Murine Lung with Reduction <strong>of</strong> Inflammation byDexamethasone Pre-TreatmentJeff Sparks, Kevin J. Polach, Richard T. Congo, Gregory Slobodkin, Angela Rea-Ramsey,Casey Pence, Majed Matar, Diane McClure, Jennifer Rice, David Ulkoski, ElaineBrunhoeber, Leslie Wilkinson, Khursheed Anwer, Jason G. Fewell.894Ornithine and Tryptophan as an Efficient Polycation for siRNADelivery to Tumor <strong>Cell</strong>sYusuke Sato, Hiroto Hatakeyama, Hideyoshi Harashima.895Influence <strong>of</strong> 5’ Terminal Triphosphate in Short Hairpin RNA TargetingHCV Replicon on Antiviral Activity and Innate Immune ResponseKyungbo Kim, Bokhui Lee, Soo-Ryoon Ryoo, Dal-Hee Min, Dong-Eun Kim.896Enhanced Delivery <strong>of</strong> GFP siRNA Using New Amino Lipid-BasedCationic LiposomesHyun-Ki Kim, Enkhzaya Davaa, Chang-seon Myung, Jeong-Sook Park.EXHIBITOR PROSPECTUSfinal program
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