13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010135Abstract DirectorySaturday, May 22, 2010Poster Session III — continued6:00 PM - 8:00 PMRoom: Exhibit Hall CMusculo-skeletal <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> III791A Comparison <strong>of</strong> Adeno-Associated Virus Mediated <strong>Gene</strong> Transferinto Healthy and Dystrophin-Deficient Skeletal MusclesGilles Moulay, Carole Masurier, Pascal Bigey, Daniel Scherman, Antoine Kichler.792In Vivo Reprogramming into the Myogenic Lineage and ImprovingEngraftment in the mdx Mouse Model <strong>of</strong> DMDLindsey A. Muir, Jeffrey S. Chamberlain.793<strong>Gene</strong> Transfer-Driven Inhibition <strong>of</strong> Cardiac Ankyrin Repeat Protein asa Potential <strong>Therapy</strong> for the Correction <strong>of</strong> Muscular DystrophiesNathalie F. Danièle, Laurence Suel-Petat, Isabelle Richard.794Background Strain and Natural Selection Improves Survival <strong>of</strong> HIBMMouse ModelYadira Valles-Ayoub, Zeshan Khokher, Arman Haghighatgoo, Daniel No, SaghiEsfandiarifard, Chai Saechao, Jennifer Kay, Christopher Creencia, Sheila Darvish, DanielDarvish.795Combining Stem <strong>Cell</strong>s and Exon Skipping Approach To Treat MuscularDystrophiesMirella Meregalli, Daniele Parolini, Andrea Farini, Marzia Belicchi, Giuseppe D’Antona,Simona Maciotta, Paola Razini, Alberto Lerario, Serena Bonfiglio, Roberto Bottinelli, LuisGarcia, Nereo Bresolin, Yvan Torrente.796<strong>Gene</strong> and <strong>Cell</strong> <strong>Therapy</strong> Approaches Tto Treating the DysferlinopathiesBradley A. Williams, Nilah Monnier, Douglas E. Albrecht, Nupur Garg, Laura E. Rufibach,Esther Hwang, Angela Salerno, Plavi Mittal.Infectious Diseases and Vaccines: Non-Vaccine Related <strong>Gene</strong>Transfer Research797Delineation <strong>of</strong> RNA Antisense env Effects on HIV QuasispeciesRecovered from Lexgenleucel-T Treated Subjects: Influences <strong>of</strong>Sequence Similarity <strong>of</strong> the RNA Antisense with the Targeted HIV envTranscript and VRX496-Modified <strong>Cell</strong> PersistenceAlexander Pasternak, Nikolay Korokhov, Vladimir Lukashov, Laurent M. Humeau.798Assessing Preclinical Safety <strong>of</strong> a CCR5-Specific Zinc Finger Nucleasein Human CD4+T <strong>Cell</strong>s Using the NSG Immunodeficient Mouse ModelS. Kaye Spratt, Marty Giedlin, Richard Carroll, Shuguang Jiang, Dawn Maier, GwendolynBinder-Scholl, Gary Lee, Lynn Truong, Bruce Levine, Michael Holmes, Philip Gregory, CarlJune, Dale Ando.799Multivirus-Specific T <strong>Cell</strong> Immunotherapy To Prevent or TreatInfections <strong>of</strong> Allogeneic Stem <strong>Cell</strong> Transplant RecipientsAnn M. Leen, Ulrike Gerdemann, Carlos A. Ramos, Tamara Tripic, Malcolm K. Brenner,Cliona M. Rooney, Juan F. Vera, Helen E. Heslop.800Inhibition <strong>of</strong> HIV-1 Replication in VRX496-Modified CD4 T <strong>Cell</strong>s:Importance <strong>of</strong> Cytoplasmic dsRNA ComponentsRandall Merling, Brit J. Hart, Ziping C. Chen, Laurent M. Humeau, Nikolay Korokhov.801Engineering Resistance to CXCR4-Tropic HIV: A Cutting EdgeApproachCraig B. Wilen, Michael C. Holmes, Jianbin Wang, Philip D. Gregory, Carl H. June, RobertW. Doms.802Development <strong>of</strong> an Unbiased Method for Characterizing ViralPopulations Using Next <strong>Gene</strong>ration Sequencing TechnologyStephanie M. Willerth, Helder L. Pedro, Laurent M. Humeau, Adam P. Arkin, David V.Schaffer.803Long Term Persistence <strong>of</strong> VRX496-Modified CD4+ T LymphocytesFollowing Lexgenleucel-T Infusions for the Treatment <strong>of</strong> HIV/AIDS:Results from a Phase 2 Clinical TrialLaurent M. Humeau, Kris Andre, Karen Bengtson, Shuyuan Zhang, Gerard McGarrity,Tessio Rebello.804<strong>Gene</strong>ration <strong>of</strong> Restriction Factor-Transgenic Cats Using LentiviralTransgenesisPimprapar Wongsrikeao, Dyana T. Saenz, Thomas A. Rinkoski, Takeshige Otoi, Eric M.Poeschla.805Combinatorial Latency Reactivation for HIV-1 Subtypes and VariantsJohn C. Burnett, John J. Rossi, Kwang-il Kim, Adam P. Arkin, David V. Schaffer.806Highly Efficient Expression and Purification <strong>of</strong> Hepatitis C Virus CoreProtein in E.coliYixin Bian, Guozhen Qiu, Tingting Li, Zixuan Chen, Wenjing Wang, Chengyao Li.807Molecular Epidemiology <strong>of</strong> HCV Infection among Recovery andChronic Blood Donors in Guangdong, ChinaTingting Li, Jinfeng Zeng, Zixuan Chen, Lifang Shuai, Anqi Wang, Chengyao Li.Saturday, May 22 nd
136<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectorySaturday, May 22 ndSaturday, May 22, 2010Poster Session III — continued6:00 PM - 8:00 PMRoom: Exhibit Hall CInfectious Diseases and Vaccines: Non-Vaccine Related <strong>Gene</strong>Transfer Research808Occult Hepatitis B Virus Infection in Shenzhen, ChinaXin Zheng, Yixin Bian, Ling Zhang, Wenjing Wang, Lifang Shuai, Anqi Wang, Jean-PierreAllain, Daniel Candotti, Chengyao Li.Cancer – Immunotherapy III809Time for TEA: T <strong>Cell</strong>s Expanded on Artificial Antigen Presenting <strong>Cell</strong>s?Hillary N. Gibbons, Carrie Yuen, Sergio Giralt, Carl H. June, Laurence J. N. Cooper.810Oxaliplatin Increases the Antitumor Effect <strong>of</strong> Vector-DeliveredInterleukin-12 Expression in a Murine Model <strong>of</strong> Hepatic ColorectalCancer MetastasesManuela Gonzalez-Aparicio, Itsaso Mauleon, Pilar Alzuguren, Sandra Hervas-Stubbs,Uxua Manchengo, Julien Crettaz, Gloria González-Aseguinolaza, Jose Medina-Echeverz,Pedro Berraondo, Jesus Prieto, Ruben Hernandez-Alcoceba.811Optimizing Dendritic <strong>Cell</strong> Vaccination by Combination with OncolyticAdenovirus Coexpressing Interleukin-12 and Granulocyte-Macrophage Colony Stimulating FactorSong-Nan Zhang, Jing-Hua Huang, Ji Young Yoo, Kyung-Ju Choi, Chae-Ok Yun.812Bacterial Vector Mediated Vaccination for Prostate CancerGarrett Casey, Sarfraz Ahmad, Michelle Cronin, Simon Rajendran, Mark Tangney, GeraldC. O’Sullivan.813Evaluation <strong>of</strong> Long-Term Transgene Expression in piggyBac-ModifiedHuman T LymphocytesYozo Nakazawa, Sunandan Saha, Daniel Galvan, Cliona M. Rooney, Matthew H. Wilson.814Engineered Drug Resistant Immunocompetent <strong>Cell</strong> <strong>Therapy</strong> forNeuroblastomaAnindya Dasgupta, David McCarty, H. Trent Spencer.815<strong>Gene</strong>tically Mediated Constitutive Expression <strong>of</strong> CD40L by T <strong>Cell</strong>sWill Induce Enhanced Immunogenicity <strong>of</strong> B-<strong>Cell</strong> MalignanciesKevin J. Curran, Raymond Yeh, Beatrijs Seinstra, Yan Nikhamin, Yelena Usachenko,Renier J. Brentjens.816Tumor Antigen Delivery to Secondary Lymphoid Organs byInterleukin-12 <strong>Gene</strong> Modified T <strong>Cell</strong>sAdham S. Bear, Xiatong Song, Meghan E. Turnis, Stephen M. Gotschalk, Cliona M.Rooney, Aaron E. Foster.817Pluronic Based Formulations Are Promising Anticancer DNA VaccinesCaroline Roques, Zagit Gaymalov, Jedd D. Wolchok, Alexander V. Kabanov.818Efficient Induction <strong>of</strong> Humoral and <strong>Cell</strong>ular Immune ResponsesAgainst Her-2/neu by Combination <strong>of</strong> Naked DNA and AdenoviralVectors Expressing <strong>Gene</strong>tically Engineered Her-2/neuJae-Gyun Jeong, Dong-Sik Kim, Sung-Won Lim, Kyu-Woong Shim, Hwang-Jae Lee, Sung-Min Oh, Jin-A Chae, Yeon-Sook Cha, Seong-Hyun Ho, Youngtae Hong, Woong Hahn,Sujeong Kim, Jong-Mook Kim, Seungshin Yu, Chang-Yuil Kang, Sunyoung Kim.819Autocrine, Not Paracrine, Interferon-Gamma <strong>Gene</strong> Delivery EnhancesEx Vivo Antigen-Specific Cytotoxic T Lymphocyte Stimulation andKillingDazhi Zhang, Liu Yong, Chang Xuan You, Rongcheng Lou, Paul L. Hermonat.820Potent Transfer <strong>of</strong> Human CD40L to Chronic Myeloid Leukemia Stem<strong>Cell</strong>s Via an AdCD40L <strong>Gene</strong>tically Engineered Bystander <strong>Cell</strong> LineLisa H. Christiansson, Lina Liljenfeldt, Bengt Simonsson, Ulla Olsson-Strömberg, AngelicaS. I. Loskog.822Preclinical Efficacy Data <strong>of</strong> MGN1601, a Tumor Vaccine Comprising4-Fold <strong>Gene</strong>-Modified and Irradiated Allogeneic Tumor <strong>Cell</strong>s inCombination with a DNA-Based Immunomodulator for the Treatment<strong>of</strong> Metastatic Renal CarcinomaBaerbel Volz, Manuel Schmidt, Kerstin Kapp, Matthias Schr<strong>of</strong>f, Marina Tschaika,Burghardt Wittig.823Electrically Mediated Delivery <strong>of</strong> Plasmid DNA-Encoding Cytokines forthe <strong>Gene</strong>ration <strong>of</strong> an Enhanced Immune Response Against MelanomaBernadette Marerro, Shawna Shirley, Loree Heller, Richard Heller.824Cytokine-Based Log-Scale Expansion <strong>of</strong> Functional Human Dendritic<strong>Cell</strong>sYui Harada, Yasuji Ueda, Hiroaki Kinoh, Aki Furuya, Makoto Inoue, Mamoru Hasegawa,Tomohiko Ichikawa, Yoshikazu Yonemitsu.825Small Plasmid/PEI/Anionic Polysaccharide Ternary ComplexParticles: Toxicity and Animal Clinical StudyYoshiyuki Koyama, Masahiko Tojyo, Chieko Yoshihara, Katsuyuki Hamada, Tomoko Ito.826Imiquimod, a TLR7 Agonist, Delays Brain Tumor Growth throughSuppression <strong>of</strong> Treg in BrainZhengming Xiong, Shoko Toma, John Ohlfest.EXHIBITOR PROSPECTUSfinal program
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