FINAL PROGRAM - American Society of Gene & Cell Therapy

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13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010 85Washington, DC Fun FactsIn Washington, DC, you’ll enjoy access to fascinating, FREE attractions andhistoric sights. Touch a moon rock, marvel at the Hope Diamond, view Dorothy’sRuby Red slippers or explore Native American culture at the SmithsonianInstitution’s fifteen Washington, DC area facilities. Discover treasures like theGutenberg Bible at the Library of Congress, the only da Vinci painting in NorthAmerica at the National Gallery of Art and historic documents like the Declarationof Independence at the National Archives. The National Zoo is also located withinwalking distance of the Marriott Wardman Park Hotel.Away from these celebrated federal sites, Washington, D.C. unwinds into afascinating network of neighborhoods where visitors discover trendy boutiques,hip bars and restaurants, plus art galleries, historic homes and lush parks andgardens. Shoppers love the store-lined streets of Georgetown, while jazz musicfans won’t want to miss a trip to U Street, where Duke Ellington played his firstnotes. The city’s international character shines through in its Adams Morganand Dupont Circle neighborhoods, two prime destinations for eclectic dining andnightlife and the historic center of the city’s embassy community.The arrival of several new eateries has made the nation’s capital a primedestination for dining out, with many of the city’s top tables located in thedowntown Penn Quarter neighborhood. DC is also earning new recognition as athriving performing arts town, with 65 professional theatre companies based inthe metropolitan area presenting edgy world premieres and celebrated Broadwaymusicals throughout the year.It’s easy to get around town thanksto DC’s pedestrian-friendly streets andits safe, efficient public transportationsystem—including Metrorail and the newCirculator bus—it’s easy to get from yourhotel to Washington, DC’s attractions. Formore information, visit www.washington.org.Hotel InformationMarriott Wardman Park Hotel2660 Woodly Road NWWashington, DCPhone: (202) 328-2000The hotel has several places you can grab a bit to eat, which include:Harry’s Pub:This Washington DC restaurant features an Old English menu. Enjoysandwiches, soups, pizzas and microbrews. Open for lunch and dinner.Illy’sGrab a bite to go at this coffeehouse featuring specialty coffees, teas andfresh baked goods.Stone’s Throw Restaurant & Bar:A steakhouse offering steaks, chops and seafood dishes that is open forbreakfast, lunch and dinnerWoodley’s MarketThis gourmet deli serves breakfast items, snacks and gourmet takeoutsandwiches and meals.Or walk through the neighborhood and enjoy over 20 eatery options.
86American Society of Gene & Cell TherapyAbstract DirectoryThursday, May 20 thThursday, May 20, 2010Oral Abstract Session 230AAV Vectors: Vector Trafficking2:00 PM - 4:00 PMRoom: Marriott Ballroom: Salons 2 & 31 2:00 PMEngineering AAV for Improved In Vitro Infectivity, In Vivo Tropismand Onset of ExpressionRu Xiao, Sadik H. Kassim, Lauren E. Mays, Deirdre McMenamin, Regina Munden, JamesM. Wilson, Luk H. Vandenberghe.2 2:15 PMTargeting Directed Evolution of AAV Capsids for Specific TherapeuticApplicationsSteven J. Gray, Bonita L. Blake, Matthew Hirsch, Hugh E. Criswell, Sarah Nicolson,Wuping Li, Thomas J. McCown, R. Jude Samulski.3 2:30 PMEnhanced Hepatic Transgene Expression Following IntravenousDelivery of Novel Stem Cell-Derived Recombinant AAV VectorsLaura J. Smith, Ariel Kauss, Kamehameha K. Wong, Saswati Chatterjee.4 2:45 PMAAV Capsid Sequence Significantly Influences Intracellular ViralTrafficking in Polarized Human Airway Epithelial CellsNicholas W. Keiser, Ziying Yan, Diana Lei-Butters, John F. Engelhardt.5 3:00 PMCell Entry Pathway Defines Efficiency and Specificity of rAAVTargeting VectorsSilke Uhrig, Jessica Sallach, David Gomez Almarza, Luca Perabo, Sabine Eming,Fernando Laguzzi Larcher, Michael Hallek, Hildegard Büning.6 3:15 PMNovel Cardiac-Tropic AAV Vectors by DNA Shuffling and In VivoScreeningZhenhua Yuan, Lin Yang, Chunping Qiao, Juan Li, Xiao Xiao.7 3:30 PMIntravenously Administered rAAV9 Vector Efficiently TransducesTissues In Vivo Via Caveolin-1-Independent Transport across theCapillary Endothelial Cell BarrierKei Adachi, Nicole M. Kotchey, Maliha Zahid, Hiroyuki Nakai.8 3:45 PMDirected Evolution of Adeno-Associated Virus Variants That EvadeHuman Neutralizing AntibodiesDaniel Stone, James T. Koerber, Federico Mingozzi, Gregory M. Podsakoff, KatherineHigh, David V. Schaffer.Oral Abstract Session 231DNA Vectorology & Gene Targeting2:00 PM - 4:00 PMRoom: Maryland Suite9 2:00 PMA Simplified Approach for Robust Minicircle DNA Vector ProductionUsing a New Genetically-Modified E. Coli Producer StrainZYCY10P3S2TZhi-Ying Chen, Cheng-Yi He, Mark A. Kay.10 2:15 PMTargeted Transgene Integration in Epidermal Stem Cells by Zinc FingerNucleases and Integrase-Defective Lentiviral VectorsGiulietta Maruggi, Angelo Lombardo, Francesca Miselli, Pietro Genovese, Michael C.Holmes, Philip D. Gregory, Alessandra Recchia, Fulvio Mavilio, Luigi Naldini.11 2:30 PMZinc Finger Nucleases Drive Efficient Gene Disruption and Site-Specific Gene Addition in Human HSCNathalia G. Holt, Kevin G. Haworth, Kathleen C. Burke, Jianbin Wang, Kenneth Kim,Geoffrey Friedman, Philip D. Gregory, Michael C. Holmes, Paula M. Cannon.12 2:45 PMManipulating piggyBacTransposon Chromosomal Integration Site-Selection in Human CellsClaudia Kettlun, Daniel Galvan, Aparna Kaja, Edward Rebar, Matthew H. Wilson.13 3:00 PMOptimized Recovery of Integration Sites from Gene-Modified CellsUsing Mu Transposition In VitroTroy L. Brady, Nirav Malani, Gary P. Wang, Charles C. Berry, Philippe Leboulch, SalimaHacein-Bey-Abina, Marina Cavazzana-Calvo, Harri Savilahti, Frederic D. Bushman.14 3:15 PMAn In Vitro-Identified High Affinity Nucleosome Positioning Signal IsCapable of Transiently Positioning a Nucleosome In VivoLia E. Gracey, Zhi-Ying Chen, Jay M. Maniar, Anton Valouev, Arend Sidow, Andrew Z.Fire, Mark A. Kay.15 3:30 PMHyperactive piggyBac-Mediated Gene Transfer in Somatic Cells InVivoJoseph E. Doherty, Liqin Zhou, Kosuke Yusa, Allan Bradley, Nancy L. Craig, Matthew H.Wilson.16 3:45 PMHoming Endonucleases for Gene TherapyAdi Barzel, Hilla Giladi, Einat Sachar, Ludmila Rivkin, Eyal Privman, Mor Paldor, TalPupko, Toni Cathomen, Eithan Galun, Martin Kupiec.EXHIBITOR PROSPECTUSfinal program
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