13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010131Abstract DirectorySaturday, May 22, 2010Poster Session III — continued6:00 PM - 8:00 PMRoom: Exhibit Hall CAdenovirus and Other DNA Virus Vectors III716Towards the <strong>Gene</strong>ration <strong>of</strong> a Baculovirus Display Library for <strong>Cell</strong>TargetingMarcel Westenberg, Helen M. Soedling, Linda J. Nicholson, Derek A. Mann, Colin T.Dolphin.717Broad Spectrum Activity <strong>of</strong> the HSV-2 Vector DRR EnhancesNeuroprotection and Includes Crosstalk between Neurons and Glial<strong>Cell</strong>sJennifer M. Laing, Laure Aurelian.718Enhanced Transduction and Replication <strong>of</strong> Fiber-Modified Adenovirusin Murine Primary T <strong>Cell</strong>sSadhak Sengupta, Ilya V. Ulasov, Atique U. Ahmed, Maciej S. Lesniak.719Cloning <strong>of</strong> the Human Herpesvirus-6A (HHV-6A) Genome into theBacterial Artificial Chromosomes (BACs) towards the Creation <strong>of</strong>Helper-Less Amplicon Vectors for Potential Use in Lymphocyte <strong>Gene</strong><strong>Therapy</strong> and VaccinationNiza Frenkel, Ronen Borenstein, Haim Zeigerman, Adi Museri, Pnina Schlesinger.720Adenovirus-Mediated Decorin Expression Induces <strong>Cell</strong> Death throughActivation <strong>of</strong> p53 and Mitochondrial ApoptosisA-Rum Yoon, Jung-Sun Lee, Chae-Ok Yun.721PEG-Modified Adenovirus Conjugated with Herceptin ImprovesTherapeutic Value by Active Targeting through Her2/neu with anEnhanced Safety Pr<strong>of</strong>ileJoung-Woo Choi.722Study on Testing Method for Adeno-Associated Virus (AAV) <strong>of</strong>Adventitious VirusYejin Choi, Nam Hee Kim, Keum S. Choi, Keerang Park, Younjoo Park.723Ad5-Ad48 Hexon Hypervariable Region Substitutions Affect ViralBiodistribution and Inflammatory Responses In VivoLynda Coughlan, Angela Bradshaw, Laura Denby, Stuart A. Nicklin, Jerome Custers, Nicovan Rooijen, Dan H. Barouch, Andrew H. Baker.724Evaluation <strong>of</strong> a Porcine Adenovirus 3 Vector as a Post-ExposureVaccine CandidateAmi Patel, Suresk K. Tikoo, Gary P. Kobinger.725The Knob Domain Replacement Strategy Is Broadly Applicable to aWide Variety <strong>of</strong> Adenovirus Fiber ProteinsGalina Mikheeva, Natalya Belousova, Victor Krasnykh.DNA Vectorology & <strong>Gene</strong> Targeting726Transcriptional Repression <strong>of</strong> Transgenes Delivered by SleepingBeauty, piggyBac and Tol2 DNA Transposon VectorsNynne Sharma, Rasmus O. Bak, Nicklas H. Staunstrup, Gernot Wolf, Jacob G. Mikkelsen.727Duration <strong>of</strong> Expression from CpG-Free Plasmids FollowingHydrodynamic Delivery to the MouseIan A. Pringle, Mary M. Connolly, Anna E. Lawton, Lee A. Davies, Stephen C. Hyde,Deborah R. Gill.728A Liver-Specific Promoter Enhances Expression <strong>of</strong> alpha-L-Iduronidasein Sleeping Beauty Transposon-Mediated <strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> MurineMPS IElena L. Aronovich, Jason B. Bell, Brenda L. Koniar, Perry B. Hackett.729New <strong>Gene</strong>ration, S/MAR Based, Episomal Vectors with HighPotential for <strong>Gene</strong> Transfer into Hematopoietic Progenitor <strong>Cell</strong>sEleana Stavrou, Vassileios Lazaris, Eirini Papapetrou, Aristeidis Giannakopoulos,Dimitra Kokkinou, Louiza Toutouna, Alexandros Spyridonidis, Nikolas Zoumbos, AglaiaAthanassiadou.730High-Yield, Non-Viral Production <strong>of</strong> Engineered <strong>Cell</strong>s throughSleeping Beauty Transposon-Mediated <strong>Gene</strong> Integration Coupled withSelective AmplificationNataly A. Kacherovsky, Maja Zavaljevski, Carl A. Blau, Cecilia M. Giachelli, Suzie H. Pun.731A Combinatorial Approach for Targeted, Systemic Delivery UsingSmall Molecules and Reversible Masking to Bypass Non-SpecificUptake In VivoNancy S. Templeton, Qiaoyun Shin, Andrew T. Nguyen, Yu Angell, Defeng Deng, Chang-Rim Na, Kevin Burgess, David D. Roberts, F. C. Brunicardi, Phillip B. Maples, JohnNemunaitis.732Using Helper Virus-Free Packaged HSV-1/EBV Hybrid Amplicons ToInduce Directed <strong>Cell</strong> Motility toward SDF-1aYasser M. El-Sherbini, Mark Stevenson, Richard Wade-Martins, Len W. Seymour.733A Novel System for the Evaluation <strong>of</strong> Genotoxicity for <strong>Gene</strong> <strong>Therapy</strong>VectorsJun Zhan, Matthew M. Wielgosz, John Gray, Arthur W. Nienhuis.Saturday, May 22 nd
132<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectorySaturday, May 22 ndSaturday, May 22, 2010Poster Session III — continued6:00 PM - 8:00 PMRoom: Exhibit Hall CDNA Vectorology & <strong>Gene</strong> Targeting734A Liver-Directed Targeting Tether Vector System To Increase Uptakein Liver <strong>Cell</strong>sJason B. Bell, Erik Olson, R. Scott McIvor, Perry B. Hackett.735<strong>Cell</strong>s Labeled with Fatty Acid-Oligonucleotide Conjugates asPotentially Suitable for Tissue EngineeringGalina E. Pozmogova, Marina A. Zaitseva, Andrey N. Chuvilin, Grigory G. Borisenko.736An Enhanced Non-Viral Expression Vector (EEV) – For CancerTreatmentPatrick F. Forde, Mira Sadadcharam, Marcel De Kruijf, Slawomir P. Salwa, Michael G.Bourke, Gerald C. O’Sullivan, Declan M. Soden.737Development <strong>of</strong> Post-Translational Tumor-Targeted-Cytokine Vectorfor Systemic Treatment <strong>of</strong> Malignant DiseaseJeffry J. Cutrera, Denada Dibra, Xuexing Xia, Shulin Li.738Improved Antibiotic-Free Plasmid Vector Design by Incorporation <strong>of</strong>Transient Expression EnhancersJeremy M. Luke, Justin M. Vincent, Clague P. Hodgson, James A. Williams.739Genomic DNA Reduction for Therapeutic DNA ManufactureYing Cai, Debra Bailey, Reto P. Bazzani, Henry Hebel, Stephen C. Hyde, StephenRodriguez, Deborah R. Gill.740Preclinical Efficacy and Safety <strong>of</strong> Electroporation-Mediated Delivery<strong>of</strong> a Plasmid Vector Manufactured in the Absence <strong>of</strong> AntibioticSelectionKaren E. Dolter, Cedric Y. Szpirer, Philippe Gabant, Drew Hannaman, Claire F. Evans.741Hepatic Stellate <strong>Cell</strong>-Specific TGF-b1 <strong>Gene</strong> Silencing for Treating LiverFibrosisNingning Yang, Ram I. Mahato.Chemical and Molecular Conjugates III742Nuclear Enclosure <strong>of</strong> Nanospheres in Artificial Nuclei and in Living<strong>Cell</strong>sNathalie Symens, Katrien Remaut, Jo Demeester, Stefaan C. De Smedt.743Analysis <strong>of</strong> Intracellular Trafficking <strong>of</strong> MPC-Coated MultifunctionalEnvelope-Type Nano Device (MPC-MEND) in Isolated HepatocyteMasami Ukawa, Hidetaka Akita, Tomoya Masuda, Yasuhiro Hayashi, Tomohiro Konno,Kazuhiko Ishihara, Hideyoshi Harashima.744Photo-Activated Release <strong>of</strong> DNA from Liposome ComplexesCaroline M. LaManna, Jiazuo H. Feng, Hrvoje Lusic, Mark W. Grinstaff.745A Novel Cationic Lipophosphoramide with Di-Unsaturated LipidChains: Synthesis, Physico-Chemical Properties, and TransfectionActivitiesTony Le Gall, Damien Loiseau, Erwan Picquet, Nathalie Carmoy, Jean Jacques Yaouanc,Laure Burel Deschamps, Pascal Delépine, Philippe Giamarchi, Paul Alain Jaffrès, PierreLehn, Tristan Montier.746Modifying DNA Nanoparticles with Biotin for Versatile LigandSubstitutionWenchao Sun, Pamela B. Davis.747An Integrative Approach To Monitor <strong>Gene</strong> Delivery to AirwayEpithelium by Nanocomplex Vectors and Radioimaging AgentsMaria D. I. Manunta, Aristides Tagalakis, Christopher O’Callaghan, Stephen L. Hart.748Development <strong>of</strong> Small, Homogenous Non-Viral <strong>Gene</strong> Vector UsingMono-Cationic DetergentsRyosuke Suzuki, Yuma Yamada, Hideyoshi Harashima.749Development <strong>of</strong> DNA Complex-Releasing Systems UsingBiodegradable Apatite Cement and Therapeutic Effect in Tumor ModelMiceTomoko Ito, Yoshiyuki Koyama, Makoto Otsuka.750Investigation <strong>of</strong> Cross-Linking Peptides as <strong>Gene</strong> Delivery VectorsAnton V. Kiselev, Anna A. Egorova, Arto O. Urtti, Vladislav S. Baranov.751Rapid and Highly Efficient Magnet<strong>of</strong>ection <strong>of</strong> IL-10 to ExtremelySusceptible Vascular Endothelial <strong>Cell</strong>s Using Hybrid Iron Oxide-PEIConjugateYong Sook Kim, In-Kyu Park, Jin Sook Kwon, Myung Ho Jeong, Youngkeun Ahn.752Cocaine Conjugated to Disrupted Adenovirus – A Synthetic/Viral Protein Hybrid Strategy To Elicit High Titers Against Non-Immunogenic Addictive Small MoleculesBishnu P. De, Martin J. Hicks, Jonathan B. Rosenberg, Stefan Worgall, Stephen M.Kaminsky, Amira Y. Moreno, Kim D. Janda, Ronald G. Crystal.753Bisphosphonate-Mediated <strong>Gene</strong>-Eluting Metal Stent as <strong>Gene</strong> VectorDelivery Using Antibody for Localized <strong>Gene</strong> DeliveryYong Wang, Cunxian Song, Robert J. Levy.EXHIBITOR PROSPECTUSfinal program
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