13 th AnnUAL MEETing | Washington, DC USA May 19-22, 2010115Abstract DirectoryFriday, May 21, 2010Poster Session II— continued6:30 PM - 8:30 PMRoom: Exhibit Hall C & B-SouthMusculo-skeletal <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> II467Detailed Physical Mapping <strong>of</strong> Deletion Breakpoints in the GSHP DogModel for DMDAlock Malik, Acong Xu, Jesse Chen, Andrew Mead, Martin Childers, Janet Bogan, ScottSchatzberg, Joe Kornegay, Hansell Stedman.468Lentiviral Vector Mediated Delivery <strong>of</strong> Full-Length Dystrophin for<strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> Muscular DystrophyEn Kimura, Katsuhisa Uchio, Tomohiro Suga, tatsuya Koide, Yuji Uchida, Yasushi Maeda,Satoshi Yamoshita, Jeffrey S. Chamberlain, Makoto Uchino.Cancer – Immunotherapy II469Elimination <strong>of</strong> Cancer Stem <strong>Cell</strong>s with <strong>Gene</strong>tically Engineered T <strong>Cell</strong>sExpressing a Stage Specific Embryonic Antigen-1 (SSEA1) ChimericAntigen ReceptorAntonina V. Kurtova, Juan Vera, An Lu, Adham Bear, Aaron E. Foster.470Targeting Cancer Stem <strong>Cell</strong>s in OsteosarcomaAlexia Ghazi, Nino Rainusso, Vita Salsman, Helen Heslop, Steven Gottschalk, NabilAhmed.471CMV-Specific HER2-Redirected T <strong>Cell</strong>s for the AdoptiveImmunotherapy <strong>of</strong> GlioblastomaAlexia Ghazi, Vita Salsman, Yvonne Kew, Donald Shaffer, Suzanne Powell, RobertGrossman, Michael Scheurer, Ann Leen, Catherine Bollard, Helen Heslop, StephenGottschalk, Nabil Ahmed.472Combining mTor Inhibitors with Rapamycin-Resistant T <strong>Cell</strong>s: A Two-Pronged Approach to Tumor EliminationLeslie E. Huye, Barbara Savoldo, Gianpietro Dotti, Matthew H. Wilson, Cliona M. Rooney.473Evaluating the Combination <strong>of</strong> 5’Azacytidine and MAGE-A4-SpecificT <strong>Cell</strong> <strong>Therapy</strong> as a Potential Immunotherapeutic Strategy forRefractory Hodgkin’s LymphomaConrad R. Cruz, Ulrike Gerdemann, Jessica A. Shafer, Ann M. Leen, Tamara Tripic, TerzahM. Horton, Anas Younes, Cliona M. Rooney, Helen E. Heslop, Catherine M. Bollard.474The iCD40.MyD88 Dendritic <strong>Cell</strong> (DC) <strong>Gene</strong> Switch Leads to PotentAnti-Tumor <strong>Therapy</strong>Natalia Lapteva, Priyadharshini Narayanan, Mamatha Seethammagari, Kevin M. Slawin,David M. Spencer.475Emozolomide Inhibits the Migration <strong>of</strong> Immune <strong>Cell</strong>s into the BrainTumor Microenvironment and Their Systemic Expansion, but Exertsa Synergistic Anti-Tumor Effect When Combined with CombinedConditional Cytotoxic/Immune-<strong>Gene</strong> <strong>Therapy</strong>Maria G. Castro, Marianela Candolfi, Kader Yagiz, Kurt M. Kroeger, David Foulad,Garbielle Ahlzadeh, Matthew Tesarfreund, Pedro R. Lowenstein.476TCR Engineered and In Vitro Expanded T Lymphocytes Recapitulatethe Properties <strong>of</strong> Central Memory T <strong>Cell</strong>sShicheng Yang, Zhili Zheng, Ling Zhang, Steven A. Rosenberg, Richard A. Morgan.477Phase I Safety and Immunogenicity <strong>of</strong> HPV 16 and 18 DNA VaccinesDelivered Via ElectroporationJian Yan, Panyupa Pankhong, Xuefei Shen, Mary Giffear, Jessica Lee, Drea Harris,Deanna Diaz, Amir Khan, Mark Bagarazzi, Jean Boyer, David B. Weiner, Niranjan Y.Sardesai.478Improving Adoptive T <strong>Cell</strong> <strong>Therapy</strong> by Transduction <strong>of</strong> TIL with aVector That Mediates the Inducible Expression <strong>of</strong> IL-12 in the TumorMicroenvironmentLing Zhang, Sid P. Kerkard, Shicheng Yang, Zhili Zheng, Zhiya Yu, Nichaolas P. Restifo,Steven A. Rosenberg, Richard A. Morgan.479Robust and Sustained Ex Vivo Expansion <strong>of</strong> NK <strong>Cell</strong>s with ArtificialAPCs Bearing Membrane-Bound IL-21 Is Associated with a DistinctPhenotype and Transcriptional Pr<strong>of</strong>ileCecele J. Denman, Vladimir Senyukov, Lisa M. Kopp, Maria Lima de Silva, Harjeet Singh,Lenka Hurton, Simon Olivares, Sourindra Maiti, Mary H. Huls, Richard E. Champlin,Laurence J. N. Cooper, Dean A. Lee.480STAT3-Inactivated Dendritic <strong>Cell</strong> Vaccination Could Induce StrongerAnti-Tumor Immune ResponsesHidetoshi Sumimoto, Tomoko Iwata-Kajihara, Hiroyuki Mizuguchi, Kiyoshi Takeda,Yutaka Kawakami.481Combination <strong>Therapy</strong> for Melanoma Using Virotherapy and AlternateTLR Stimulating AgonistsRosa Diaz, Marta Compte-Grau, Elizabeth Ilett, Phonphimon Wongthida, Feorillo Galivo,Timothy Kottke, Jill Thompson, Alan Melcher, Richard Vile.482Bid Is a Key Factor for Eliciting the Antiproliferative Activity <strong>of</strong> IFN-aMediated by TRAILTakaya Tsuno, Josef Mejido, Tongmao Zhao, Terry Phillips, Kathryn Zoon.483Oral Adeno-Associated Virus-neu (AAV-neu) Immunotherapy Inhibitsthe Growth <strong>of</strong> neu+ Murine Breast CancerJason C. Steel, Giovanni Di Pasquale, Charmaine A. Ramlogan, Caroline Morris, John A.Chiorini, John C. Morris.Friday, May 21 st
116<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>Abstract DirectoryFriday, May 21 stFriday, May 21, 2010Poster Session II— continued6:30 PM - 8:30 PMRoom: Exhibit Hall C & B-SouthCancer – Immunotherapy II484Tumor-Specific Antitumor Activity <strong>of</strong> mIL-10 Revealed byHydrodynamic Tail Vein Injection <strong>of</strong> pCMV-mIL Plasmids in Tumor-Bearing MiceJianfeng Li, Li Hai, Shulin Li, Dexi Liu.485Liver Specific, Inducible, AAV-Mediated IL12 Delivered Resulted ina Strong Anti Tumoral Inmune Response in a Murine Model <strong>of</strong> LiverMetastasisLucia Vanrell, Laura Blanco, Pedro Berraondo, Marianna Di Scala, Astrid Paneda, VictorBaldim, Jesus Prieto, Gloria González-Aseguinolaza.486AdCD40L <strong>Gene</strong> <strong>Therapy</strong> Enhances the Efficacy <strong>of</strong> Chemotherapy inExperimental Bladder CancerLina S. E. Liljenfeldt, Lisa H. Christiansson, Katerina Gkirtzimanaki, Angelica S. I. Loskog,Aristides G. Eliopoulos.487Xenograft Expanded FANG Autologous Tumor <strong>Cell</strong> VaccineDevelopment and Manufacturing for Clinical UsePhillip B. Maples, Padmasini Kumar, Yang Yu, Beena O. Pappen, David Monsma,Stephanie Scott, Dawna Dylewski, Craig Webb, Neil Senzer, John Nemunaitis.Cancer-Oncolytic Viruses II488Optimization <strong>of</strong> Measles Virus Infected Mesenchymal Stem <strong>Cell</strong>Carriers for Clinical Testing in Patients with Recurrent Ovarian CancerKah-Whye Peng, Emily K. Mader, Greg Butler, Marla Sommerfield, Sean C. Dowdy, AllanB. Dietz.489Expression <strong>of</strong> Interferon Alpha from an Oncolytic Adenovirus VectorDecreases Toxicity but Retains the Anti-Tumor Efficacy <strong>of</strong> the VectorJacqueline F. Spencer, Debanjan Dhar, Elena V. Shashkova, Karoly Toth, William S. M.Wold.490Measles Virus Encoding H. pylori Neutrophil-Activating Protein forTreatment <strong>of</strong> Metastatic Breast CancerIanko D. Iankov, Cory Allen, Stephen J. Russell, Mark J. Federspiel, Evanthia Galanis.491Carrier <strong>Cell</strong>s Delivery <strong>of</strong> Inducible Oncolytic Adenovurs for BrainTumorHiroshi Nakashima, E. A. Chiocca.492Optimizing the Genomic Stability, Transgene Expression, andTherapeutic Efficacy <strong>of</strong> Replication-Competent Retrovirus Vectors forProdrug Activator <strong>Gene</strong> TransferKei Hiraoka, Logg R. Christopher, Akihito Inagaki, Hiroshi Matsumoto, Oscar Diago,Omar Perez, Joan Robbins, Harry Gruber, Douglas Jolly, Noriyuki Kasahara.493<strong>Gene</strong> <strong>Therapy</strong> for Head and Neck Squamous Carcinoma <strong>Cell</strong>s byIAI.3B Promoter-Driven Oncolytic Adenovirus-Infected Carrier <strong>Cell</strong>sKatsuyuki Hamada, Ting Zhang, Koh-ichi Nakashiro, Hiroyuki Hamakawa.494Evaluation <strong>of</strong> Monocytes and Cancer <strong>Cell</strong>s as Carriers for OncolyticAdenoviruses in Immune-Competent Models <strong>of</strong> Pancreatic Cancer inSyrian HamstersEva Garcia-Aragoncillo, Sergia Bortolanza, Maria Buñuales, Jesus Prieto, RubenHernandez-Alcoceba.495Combination <strong>Therapy</strong> for Breast Cancer Using Oncolytic Viruses andHistone Deacetylase InhibitorsHongxun Wang, Stephen J. Russell, Jian Qiao.496Combination Oncolytic VirotherapyTimothy Kottke, Jill Thompson, Konstantin Doronin, Sonia Guedan Carrio, William Wold,Ramon Alemany, Richard Vile.497Conditionally Replicative Adenovirus with an Adenoviral Major LatePromoter-Driven Imaging Cassette Predicts In Vivo Anti-Tumor EffectJulia Davydova, Tatyana Gavrikova, Eric J. Brown, Xianghua Luo, David T. Curiel, SelwynM. Vickers, Masato Yamamoto.498Susceptibility <strong>of</strong> Neuroblastoma Primary Tumor-Initiating <strong>Cell</strong>s toOncolytic Herpes Simplex Virus Is Determined by Nectin-1 ExpressionPin-Yi Wang, Mark A. Currier, Margaret H. Collins, Betsy A. DiPasquale, Loen Hansford,David Kaplan, Sean Lawler, E. Antonio Chiocca, Timothy P. Cripe.499Activity <strong>of</strong> Oncolytic Measles Virus Strains Against Brain Tumor Stem<strong>Cell</strong>sCory Allen, Mark A. Schroeder, Jann N. Sarkaria, Mark J. Federspiel, Stephen J. Russell,Evanthia Galanis.500Replication-Competent Retrovirus Vector-Mediated Suicide <strong>Gene</strong><strong>Therapy</strong> Achieves Significant Therapeutic Efficacy Against HumanMalignant Mesothelioma XenograftsYoshiko Kawasaki, Norie Yamaoka, Nobuyuki Terada, Haruki Okamura, NoriyukiKasahara, Shuji Kubo.501Oncolytic Adenovirus with Somatostatin Motif for Selective Infection<strong>of</strong> Neuroendocrine TumorsDi Yu, Justyna Leja, Berith Nilsson, Magnus Essand.EXHIBITOR PROSPECTUSfinal program
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