FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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106<br />
8th Annual Meeting • June 1 - 5, 2005 • St. Louis<br />
ABSTRACTS<br />
SATURDAY, JUNE 4<br />
987<br />
Foamy Virus Vectors That Block HIV Infection<br />
Jason Taylor, Ingrid Bahner, Lucia Vojtech, Erik Olson, James<br />
Allen, Dorothee von Laer, Donald B. Kohn, David W. Russell,<br />
Robert E. Richard<br />
988<br />
The Utility <strong>of</strong> rAAV as a <strong>Gene</strong>tic Vaccine Vector for<br />
Malaria<br />
Grant Logan, Maolin Zhang, Ross Coppel, Peter Rowe, Lina<br />
Wang, Ian Alexander<br />
989<br />
Toward Multivalent Adeno-Based Vaccine for Malaria:<br />
Effects <strong>of</strong> Promoter Strength on Immunogenicity and<br />
Vaccine Efficacy<br />
Joseph T. Bruder, Maureen E. Stefaniak, Duncan McVey,<br />
Damodar Ettyreddy, Noelle B. Patterson, Fe Baraceros, Joseph J.<br />
Campo, C. R. King, Denise L. Doolan<br />
990<br />
Unexpected Immune Enhancement by Autologous<br />
Lentiviral Modified CD4 T <strong>Cell</strong>s: Results from a Phase I<br />
<strong>Gene</strong> Transfer Trial <strong>of</strong> Lentiviral Vector-Modified T <strong>Cell</strong>s<br />
Expressing Antisense Envelope<br />
Rob R. MacGregor, Bruce L. Levine, Xiaobin Lu, Laurent M.<br />
Humeau, Tessio Rebello, Peter Manilla, Yajin Ni, Gwendolyn<br />
K. Binder, Richard Carroll, Jean Boyer Frederic Bushman,<br />
Vladimir Slepushkin, Boro Dropulic, Carl H. June<br />
991<br />
Adenovirus-Mediated IL-12 <strong>Gene</strong> Transfer Increase Virus<br />
Specific CD8 T <strong>Cell</strong> Response in Aged Mice<br />
Jian Chen, PingAr Yang, Qi Wu, Allan J. Zajac, Xiaohong<br />
Wang, Kohtaro Fujihashi, Hui-Chen Hsu, John D. Mountz<br />
992<br />
Suppression <strong>of</strong> the HIV-1 Long Terminal Repeat by<br />
Transducible Artificial Transcription Factors<br />
Hyun-chul Shin, Heung-sun Kwon, Eui-chul Park, Jin-soo<br />
Kim<br />
993<br />
Mouse Model <strong>of</strong> Acute Hepatitis Using Adenovirus<br />
Vector Designed for <strong>Gene</strong> <strong>Therapy</strong><br />
Tamon Nishino, Katsuhito Iikura, Toya Ohashi, Yoshikatsu Eto<br />
994<br />
E1 Adenovirus <strong>Gene</strong> Transfer Vectors Inhibit HIV-1<br />
Replication in Human Alveolar Macrophages<br />
Robert J. Kaner, Francisco Santiago, Ronald G. Crystal<br />
995<br />
Effect OF BCL-2 Overexpression on Plasmodium<br />
Infection<br />
Francisco Martinez-F, Jose Luis Ventura, Luis F. Covarrubias,<br />
Alejandro Zentella-D, Martha Legorreta-H<br />
Infectious Diseases and Vaccines: RNAi for <strong>Gene</strong><br />
<strong>Therapy</strong> <strong>of</strong> Infections<br />
996<br />
Development <strong>of</strong> an siRNA Based <strong>Therapy</strong> for Ebola<br />
Virus Infection<br />
Thomas W. Geisbert, Lisa E. Hensley, Kristopher M. Curtis,<br />
Joan B. Geisbert, Kathleen M. Daddario, Elliott Kagan, Amy<br />
C. H. Lee, Lorne Palmer, Lloyd Jeffs, Ian MacLachlan<br />
997<br />
Loop Composition as Well as Orientation <strong>of</strong> the Guide<br />
Strand in shRNA May Dramatically Modulate Activity <strong>of</strong><br />
the shRNA: Effect on the Development <strong>of</strong> RNAi-Based<br />
Inhibitors<br />
Alexander A. Kolykhalov, Michael W. Graham, David A. Suhy,<br />
Peter W. Roelvink, Annette R. Schroeder, Amy E. Parker, Luz<br />
M. Garcia, Mark A. Kay, Sara M. Cunningham, Linda B.<br />
Couto<br />
998<br />
The HIV-1 LTR-hsp70 Fusion Promoter Directs HIV-1<br />
Inducible Expression <strong>of</strong> Anti-Rev siRNA along with<br />
HIV-1 Rev Transdominant Mutant RevM10<br />
Hoshang J. Unwalla, Ingrid Bahner, Ha-Tang Li, Ming-Jie Li,<br />
Donald Kohn, John J. Rossi, Yuliya Gokhgauzer<br />
999<br />
siRNA-Mediated Interference <strong>of</strong> Double-Stranded RNA<br />
Binding Protein [E3L] Is an Effective Strategy to Inhibit<br />
Vaccinia Virus<br />
Dave S. Rajnish, James P. McGettigan, Giuseppe Nunnari,<br />
Matthias J. Schnell, Roger J. Pomerantz<br />
1000<br />
In Vitro and In Vivo Evaluation <strong>of</strong> Optimized Short-<br />
Hairpin RNAs for the Treatment <strong>of</strong> the Hepatitis C Virus<br />
Using Expression Cassettes Producing One, Two or<br />
Three Anti HCV shRNAs<br />
David A. Suhy, Linda B. Couto, Alexander A. Kolykhalov,<br />
Amy E. Parker, A. Rosanna Schroeder, Luz Maria Garcia,<br />
Gabriel Haniff, Sara M. Cunningham, Mark A. Kay, Peter W.<br />
Roelvink<br />
1001<br />
Knockdown <strong>of</strong> CXCR4 Expression Sufficient for Blocking<br />
HIV-1-Infection Requires Combinatorial Intrabody<br />
and siRNA Mediated HIV-1 Vector <strong>Gene</strong> Delivery<br />
Christina H. Swan, Mario P. Tschan, Carlos F. Barbas, III,<br />
Bruce E. Torbett<br />
1002<br />
Therapeutic Design Principles for Achieving Long-Term<br />
Suppression <strong>of</strong> HIV-1 with RNA Interference<br />
Joshua N. Leonard, David V. Schaffer<br />
1003<br />
Inhibition <strong>of</strong> HBV Replication In Vivo by HBx-Specific<br />
siRNA<br />
Sooin Kim, Duckhyang Shin, Meehyein Kim, Mahnhoon Park
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