FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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70<br />
8th Annual Meeting • June 1 - 5, 2005 • St. Louis<br />
ABSTRACTS<br />
FRIDAY, JUNE 3<br />
402 3:30 PM<br />
Comparison <strong>of</strong> Pseudotyped rAAV Vectors for Transduction<br />
<strong>of</strong> Primary Hematopoietic Stem and Progenitor<br />
<strong>Cell</strong>s Assayed In Vitro and In Vivo<br />
Lijing Li, Sarah Hardy, Leslie Smith-Powell, Sai Srinivas,<br />
Stephen J. Forman, K. K. Wong, Saswati Chatterjee<br />
403 3:45 PM<br />
Defined Vector Substrates Used To Probe rAAV DNA<br />
Integration<br />
Douglas M. McCarty, Vivian Choi, Alda Fernandes, R. J.<br />
Samulski<br />
404 4:00 PM<br />
Roles <strong>of</strong> Inverted Terminal Repeats (ITRs) and Capsid<br />
Proteins from Novel NHP AAVs in rAAV Mediated<br />
<strong>Gene</strong> Transfer<br />
Xiaoyang Zhou, Guangping Gao, Roland A. Owens, You Lu,<br />
Roberto Calcedo, Jim Miller, James M. Wilson<br />
405 4:15 PM<br />
Comparison Study <strong>of</strong> Structural Determinants for AAV<br />
Liver Transduction by Domain Swapping between AAV-2<br />
and AAV-8 Capsids<br />
Xuan Shen, Hui Xu, Zan Huang, Theresa A. Storm, Mark A.<br />
Kay<br />
Oral Abstract Session 332<br />
Adenovirus Vectors: Innate Immunity<br />
Room: 120/124<br />
406 2:00 PM<br />
Role <strong>of</strong> MyD88 Signaling Pathway in the Host Immune<br />
Responses in Adenoviral Vector-Mediated <strong>Gene</strong> <strong>Therapy</strong><br />
Zhe Zhang, Guang Ping Gao, Lee M. Wetzler, Yan Zhi, James<br />
M. Wilson<br />
407 2:15 PM<br />
Complement Blockade Prevents Several Innate Toxicities<br />
Rapidly Induced after Intravenous Adenovirus (Ad)<br />
Vector Administration<br />
Anne Kiang, Zachary Hartman, Jun-Ping Wei, Ruth Everett,<br />
Delila Serra, Haixiang Jiang, Michael M. Frank, Andrea<br />
Amalfitano<br />
408 2:30 PM<br />
The Kupffer <strong>Cell</strong> Scavenger Receptor Is Accountable for<br />
Hepatic Sequestration <strong>of</strong> Adenovirus<br />
Hidde J. Haisma, Anna Rita Bellu, Marianne G. Rots, Gera<br />
Kamps, Josee Plantinga, Jan Kamps<br />
409 2:45 PM<br />
Identifying Functional Adenovirus-Host Interactions<br />
Using Tandem Mass Spectrometry<br />
Anuj Gaggar, Martin Sadilek, Andre Lieber, Dmitry M.<br />
Shayakhmetov<br />
410 3:00 PM<br />
Adenovirus Activates Mouse Platelets and Induces<br />
Platelet Leucocyte Association<br />
Maha Othman, Andrea Labelle, David Lillicrap<br />
411 3:15 PM<br />
Trapping <strong>of</strong> Adenovirus Vectors in Blood<br />
Daniel Stone, Shaoheng Ni, Zong-Yi Li, Dmitry M.<br />
Shayakhmetov, Andre Lieber<br />
412 3:30 PM<br />
Renal Pathophysiology after Systemic Administration <strong>of</strong> a<br />
Recombinant Adenovirus: Changes in Drug Metabolism<br />
Based upon Vector Dose<br />
Michael P. Boquet, Hong T. Le, Erin A. Clark, Shellie M.<br />
Callahan, Maria A. Croyle<br />
413 3:45 PM<br />
Functional Differences <strong>of</strong> the Reticuloendothelial System<br />
in C57BL/6 and Balb/c Mice Mediate Differential Effects<br />
<strong>of</strong> Kuppfer <strong>Cell</strong> Blockade, Rag-Deficiency and Splenectomy<br />
on Transgene Expression after Adenoviral Transfer<br />
Jan Snoeys, Geertrui Mertens, Joke Lievens, Désiré Collen, Erik<br />
Biessen, Bart De Geest<br />
414 4:00 PM<br />
Vitamin B : A Key Component for Controlled Inactiva-<br />
2<br />
tion <strong>of</strong> Viruses Suitable for Biological Use<br />
Shellie M. Callahan, Piyanuch Wonganan, Linda J. Obenauer-<br />
Kutner, Suganto Sutjipto, Hong T. Le, Maria A. Croyle<br />
415 4:15 PM<br />
Evaluating Polyethylene Glycol (PEG) Modified Adenoviral<br />
Vectors for <strong>Cell</strong> Targeting and Detargeting and<br />
Reducing Vector Toxicity<br />
Hoyin Mok, Michael A. Barry<br />
Oral Abstract Session 333<br />
Inborn Errors <strong>of</strong> Metabolism - Liver and Storage<br />
Disorders<br />
Room: 260/264<br />
416 2:00 PM<br />
Glucose-Dependent Insulin Production by Liver-<br />
Specific, Glucose-Regulatable Synthetic Promoters<br />
Results in the Cure <strong>of</strong> Diabetes<br />
Jaeseok Han, Brienne McLane, Hee-Sook Jun, Ji-Won Yoon<br />
417 2:15 PM<br />
Meganuclease-Mediated Chromosomal Surgery in Living<br />
Animals<br />
Agnes Gouble, Julianne Smith, Christophe Perez, Valerie<br />
Guyot, Jean-Pierre Cabaniols, Sophie Leduc, Laurence Fiette,<br />
Patrick Ave, Beatrice Micheaux, Philippe Duchateau Frederic<br />
Paques
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