FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 83<br />
ABSTRACTS<br />
FRIDAY, JUNE 3<br />
619<br />
Co-Expression <strong>of</strong> AAV Mediated Angiopoietin-1 and<br />
VEGF in Ischemic Hearts Yield Leakage-Resistant Blood<br />
Vessels and Better Therapeutic Effect Than VEGF Alone<br />
Hua Su, Shuji Joho, Yu Huang, Alicia Barcena, Janice<br />
Arakawa-Hoyt, William Grossman, Yuet W. Kan<br />
620<br />
SMC-Specific Transcription Elements for Improved<br />
Adenoviral-Mediated Transgene Expression in Saphenous<br />
Veins<br />
Angelika B. Kritz, Song Wan, Anthony P. C. Yim, Paul A.<br />
Kingston, Andrew H. Baker<br />
621<br />
Angiogenesis and Arteriogenesis in Ischemic Skeletal<br />
Muscles Following VEGF <strong>Gene</strong> Transfer by Adeno-<br />
Associated Virus Serotype 1 Vectors<br />
Hua Yan, Xiaobing Wu, Lingyun Zu, Yanhong Guo, Peng<br />
Zhang, Wei Gao<br />
622<br />
PhiC31 Integrase as a Tool: <strong>Gene</strong> <strong>Therapy</strong> for Angiogenesis<br />
Joylette L. Portlock, Sohail Jarrahian, Carmen Bertoni, Thomas<br />
A. Rando, Michele P. Calos<br />
623<br />
Receptor-Independent <strong>Cell</strong> Entry <strong>of</strong> Adenovirus-<br />
Polylactide Nanoparticle Composites Leads to an<br />
Increased <strong>Gene</strong> Expression in Endothelial and Smooth<br />
Muscle <strong>Cell</strong>s<br />
Michael Chorny, Ilia Fishbein, Ivan Alferiev, Origene<br />
Nyanguile, Robert J. Levy<br />
624<br />
Development <strong>of</strong> a Novel Ribbon-type NF-kðB Decoy<br />
Oligodeoxynucleotides to Treat Cardiovascular Diseases<br />
Mariana K. Osako, Naruya Tomita, Yasuo Kunugiza, Keishi<br />
Sekiguchi, Keiko Izawa, Ryuichi Morishita<br />
625<br />
Adenoviral-Mediated <strong>Gene</strong> Delivery <strong>of</strong> a Constitutively<br />
Active Form <strong>of</strong> Early Growth Response Factor-1 Increases<br />
Tissue Perfusion in a Murine Model <strong>of</strong> Hindlimb<br />
Ischemia<br />
Jonghoe Byun, Young-Sam Lee, Hyung-Suk Jang, Jeong-Min<br />
Kim, Jung-Sun Lee, Jae-Young Lee, Koung Li Kim, In-Soon<br />
Shin, Wonhee Suh, Jin-Ho Choi Eun-Seok Jeon, Duk-Kyung<br />
Kim<br />
626<br />
Ultrasound-Triggered/Enhanced Delivery <strong>of</strong> Oligonucleotides<br />
into Aorta<br />
Shao-LIng Huang, David D. McPherson, Robert C.<br />
MacDonald<br />
627<br />
Adenoviral-Mediated Systemic Transduction <strong>of</strong> the<br />
Angiotensin II (Ang II) Type 2 Receptor (AT2R) Enhances<br />
the Hypotensive Action <strong>of</strong> Losartan<br />
Hongwei Li, Yongxin Gao, Justin Grobe, Mohan Raizada,<br />
Michael Katovich, Colin Sumners<br />
628<br />
Adenovirus-Mediated Expression <strong>of</strong> bð-Adrenergic<br />
Receptor Kinase C-Terminus Reduces Intimal Hyperplasia<br />
and Luminal Stenosis in a Pig Model <strong>of</strong> Arteriovenous<br />
Polytetrafluoroethylene Graft Failure<br />
Zhengyu Luo, Ge<strong>of</strong>frey Y. Akita, Taro Date, Chris Treleaven,<br />
Karen A. Vincent, Denise Woodcock, Seng H. Cheng, Richard J.<br />
Grogery, Canwen Jiang<br />
629<br />
Successful <strong>Gene</strong> <strong>Therapy</strong> Against Atherosclerosis by AAV<br />
Delivery <strong>of</strong> IL-10 and TGFbðACT Jay L. Mehta, Yong Liu, Jaiwei Chen, Dayuan Li, Paul L.<br />
Hermonat<br />
630<br />
In Vivo h- VEGF <strong>Gene</strong> Transfer Improves Early<br />
165<br />
Endothelialisation and Patency in Synthetic Vascular<br />
Grafts<br />
Mika Lahtinen, Vitas Zemgulis, Pontus Blomberg, Giedrius<br />
Baliulis, Fredrik Carlsson, Harry Khamis, David Bergqvist<br />
631<br />
Novel Therapeutic Approach Using siRNA to Reduce<br />
Plasma High Concentration <strong>of</strong> Lp(a)<br />
Naruya Tomita, Keiko Izawa, Yasuo Kunugiza, Mariana K.<br />
Osako, Ryuichi Morishita<br />
632<br />
Adenoviral Mediated Nuclear Factor kappa B Super<br />
Repressor <strong>Gene</strong> Transfer to Rat Insulinoma <strong>Cell</strong>s Protects<br />
Against Cytokine Induced Oxidative Damage<br />
Cillian T. McCabe, Timothy O’Brien<br />
633<br />
Synergistic Effects <strong>of</strong> Naked DNA Vectors Encoding<br />
VEGF and bFGF on Angiogenesis and Blood Flow<br />
Recovery in Ischemic Hindlimb<br />
Jung-Sun Lee†, Jonghoe Byun†, Jeong-Min Kim, Chae-Young<br />
Kim, Byong-Moon Kim, Ji Hyung Chung, Yangsoo Jang,<br />
Duk-Kyung Kim<br />
634<br />
Proliferation and Angiogenesis in Vascular <strong>Cell</strong>s<br />
Overexpressing NOS Is<strong>of</strong>orms<br />
Ronan J. Cooney, Timothy O’Brien<br />
635<br />
Experimental Study on Changes <strong>of</strong> the Revascularization<br />
and Expression <strong>of</strong> VEGF and Its Receptors in Ischemic<br />
Skeletal Muscle<br />
Wei Liang, Baigen Zhang, Hao Zhang, Jiwei Zhang,<br />
Zhaoxiong Zhou
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