Bariatric treatments for adult obesity - Institute of Health Economics

Clinical practice guidelines/care pathways: for clinical indications/contraindications for thevarious treatment strategies.Data extractionOne reviewer (BG) extracted data from the included systematic reviews/HTAs according to apredetermined data extraction form.search strategy (databases searched and search dates)study selection criteria (inclusion and exclusion criteria)characteristics of the included studies (patients characteristics: number, age, gender,ethnic origin, baseline weight, BMI, and comorbidity; intervention characteristics: type, dose,duration, drop-out rate, follow-up)methodological quality of the included studiesresultsevidence of safetyo Any adverse events associated with the treatment strategiesevidence of efficacyo anthropometric outcomes: body weight, BMI, waist circumferenceo biomedical/physical outcomes: fasting glucose, total cholesterol, low-densitylipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides,ratio of total cholesterol to HDL cholesterol, and systolic and diastolic blood pressureo clinical outcomes: comorbidities, mortality, and quality of lifeo psychosocial outcomes: depression, mood disorders and eating disorders, suicidalbehaviour, and suicideMethodological quality assessmentTwo reviewers (BG and MO) independently assessed methodological quality of the included studiesusing an IHE quality assessment tool for systematic reviews. The quality rating results from the tworeviewers were compared and discrepancies between the reviewers’ results were resolved bydiscussion.Data analysis and synthesisData extracted from the included systematic reviews/HTAs were described and integrated using anarrative approach.External reviewMembers of the provincial expert advisory committee assembled for this project reviewed this draftreport.Bariatric treatments for adult obesity 109