Severe <strong>obesity</strong> is associated with decreased health-related quality <strong>of</strong> life (HRQoL), a term that refersto the burden <strong>of</strong> suffering and the limitations in physical, occupational/vocational, and socialfunctioning associated with illness. 1,6,39,40,52-55,57,67,68,72 Affected individuals frequently report that thepervasiveness and severity <strong>of</strong> their impairments are their strongest motivators <strong>for</strong> seeking bariatrictreatment. Additionally, impairments in HRQoL may account <strong>for</strong> increased symptoms <strong>of</strong> depression.Persons who have significant limitations in their functional abilities due to <strong>obesity</strong> could be expectedto have impaired occupational function. 39,40,54 Severe <strong>obesity</strong> has been associated with greatermorbidity and a poorer HRQoL than smoking/drinking problems (alcoholism) or poverty. 40Emotional suffering may be one <strong>of</strong> the most painful consequences <strong>of</strong> <strong>obesity</strong>. 1,6,12,19,25,39,40,53-55,57,58,60,70,75Socially, individuals with <strong>obesity</strong>, particularly those affected by severe <strong>obesity</strong>, have to deal withstigmatization, prejudice, discrimination, and social rejection/isolation. The prevalence <strong>of</strong> weightbias and discrimination in the United States has increased by 66% over the past decade and iscomparable to rates <strong>of</strong> racial discrimination, especially among women. 75Society emphasizes physical appearance and <strong>of</strong>ten equates attractiveness with slimness, especially <strong>for</strong>women. 19,39,40,53-55,57,58,60,70,75,76 Obesity is <strong>of</strong>ten viewed as the physical manifestation <strong>of</strong> a character flaw,and the psychosocial problems <strong>of</strong> individuals with <strong>obesity</strong> are attributed to their character ratherthan to their condition. Also, weight bias and discrimination translate into inequities in employmentsettings, health-care facilities, and educational institutions. As a result, obese individuals feelmisunderstood and neglected.Epidemiology <strong>of</strong> <strong>adult</strong> <strong>obesity</strong> and population dynamics <strong>of</strong> affected individualsOver the past several decades, the worldwide prevalence <strong>of</strong> <strong>obesity</strong> (BMI ≥ 30 kg/m 2 ) has increasedsteadily among all demographic groups and countries with developed market economies are leadingthe way. 1,6,7,13,23-25,31,38,42,44,46,56,73,74,77-80 The <strong>obesity</strong> subgroups experiencing the most rapid growth arethe severe/extreme/morbid class and the moderate class (class III and class II, when BMI reaches40 kg/m 2 or even only 35 kg/m 2 if associated with comorbidities). 11,29,68,73,74,77,81-83The latest World <strong>Health</strong> Organization estimates indicate that globally in 2005 at least 400 million<strong>adult</strong>s were obese and, projecting that, by 2015 more than 700 million <strong>adult</strong>s will be obese(www.who.int/mediacentre/factsheets/fs311/en/index.html, accessed 23 July 2010). According tothe WHO, there are 300 million <strong>adult</strong>s with class I or II <strong>obesity</strong> and 30 million with class III<strong>obesity</strong>. 79The prevalence is rising at an even faster rate among children and adolescents. 2,27,56,61,69 TheInternational Obesity Task Force estimates that more than 155 million children worldwide areoverweight or obese. 56 According to the WHO, worldwide, at least 20 million children under the age<strong>of</strong> 5 were overweight in 2005 (www.who.int/mediacentre/factsheets/fs311/en/index.html, accessed23 July 2010).At the same time, the prevalence <strong>of</strong> <strong>obesity</strong> is rapidly increasing in the elderly population; this hasbecome a growing concern. 14,15,56,61,63-66,78,84-87The reported gap in <strong>obesity</strong> prevalence between women and men is usually small and the ratesincrease <strong>for</strong> both men and women, up to age 60 to 69, and then decline. 6,17,25,28,29,38,43,44,46,61,77,88 Studiesin countries with developed market economies have usually noted an inverse relationship betweenBMI and socioeconomic status, particularly among women. 10,28,43,88,89<strong>Bariatric</strong> <strong>treatments</strong> <strong>for</strong> <strong>adult</strong> <strong>obesity</strong> – March 2012 8
Considerable variation in the prevalence <strong>of</strong> <strong>obesity</strong> occurs among and within countries <strong>of</strong> theWestern hemisphere. 9,10,25,28,46,77,78,88,89 However, comparisons <strong>of</strong> the data collected by/<strong>for</strong> differentcountries are complicated by the differences in year <strong>of</strong> data collection, the age range <strong>of</strong> thepopulation studied, and the location <strong>of</strong> data collection (urban, rural, nationally representative).Adult <strong>obesity</strong> in the United StatesThe National Center <strong>for</strong> <strong>Health</strong> Statistics at the Centers <strong>for</strong> Disease Control and Prevention (CDC)in the United States released the 2009 National <strong>Health</strong> Interview Survey (NHIS)(www.cdc.gov/nchs/nhis/released201006.htm#6) in June 2010. This survey (based on interviewswith 88,129 individuals) found that 28% <strong>of</strong> US <strong>adult</strong>s 20 years and older were considered obese(BMI ≥ 30 kg/m 2 ). This is slightly higher than the 2008 estimate <strong>of</strong> 27.6%. The annual prevalence <strong>of</strong><strong>obesity</strong> has increased steadily from the 19.4% reported in 1997. Obesity was higher among <strong>adult</strong>saged 40 to 59 (31.6%) than among <strong>adult</strong>s aged 20 to 39 (24.9%) and those aged 60 years and older(27.0%). There was no significant difference between genders. Non-Hispanic white women and menwere less likely than Hispanic women and non-Hispanic black women to be obese. Non-Hispanicwhite women were less likely than non-Hispanic white men to be obese and non-Hispanic blackwomen were more likely than non-Hispanic black men to be obese.The prevalence <strong>of</strong> <strong>obesity</strong> has increased over the past years among both genders, in all age andethnic groups, and at all educational levels. 35,44,50,51,57,73,90-93 The most rapid increases in <strong>obesity</strong>prevalence are in its most severe <strong>for</strong>ms. 44,57,73,90 Approximately 5% <strong>of</strong> <strong>adult</strong> Americans suffer fromsevere <strong>obesity</strong>, 14,15,57,90 which affects 20% <strong>of</strong> the <strong>obesity</strong>-affected US population. 73 Approximately 20to 25% <strong>of</strong> children are either overweight or obese and the prevalence is even greater in someminority groups, including Pima Indians, Mexican Americans, and African Americans. 35,44Evidence from a meta-regression analysis published in 2007 predicts that 41% <strong>of</strong> <strong>adult</strong> Americanswill become obese by 2015. 50 If these trends in <strong>obesity</strong> prevalence continue, by 2030 the number <strong>of</strong><strong>adult</strong>s with <strong>obesity</strong> will be 1.12 billion, representing more than 86% <strong>of</strong> <strong>adult</strong>s in the US. 90Adult <strong>obesity</strong> in CanadaIn Canada, the overall prevalence <strong>of</strong> <strong>obesity</strong> has increased over the past several decades amongchildren, adolescents, and <strong>adult</strong>s <strong>of</strong> both genders, in all areas <strong>of</strong> the country, and it continues torise. 1,3,8-12,16,17,24,28,29,31-33,47,68,69,81,88,94-96 Canadian statistics rely upon a number <strong>of</strong> different surveys <strong>of</strong>nationally representative samples. These surveys vary in regard to cut-<strong>of</strong>f points, referencepopulations, and data collection techniques (most used self-reported heights and weights; only somewere based on directly measured heights and weights). Regardless <strong>of</strong> the specific studies or surveys,both self-reported and directly measured data have shown a steady increase in <strong>obesity</strong> prevalenceamong <strong>adult</strong>s aged 18 or older since 1970, with the most rapid increase being seen in <strong>obesity</strong> classesII and III.An examination <strong>of</strong> self-reported BMI data from seven surveys, conducted from 1985 through 2003,<strong>of</strong> nationally representative samples <strong>of</strong> Canadian <strong>adult</strong>s found that the overall prevalence <strong>of</strong> selfreported<strong>obesity</strong> increased from 6.1% in 1985 to 15.7% in 2003. 16,81 The investigators also found thatthe prevalence <strong>of</strong> class I <strong>obesity</strong> increased from 5.1% in 1985 to 11.5% in 2003. The prevalence <strong>of</strong>class II <strong>obesity</strong> increased from 0.8% to 3.0%, while class III <strong>obesity</strong> rates increased from 0.4% to1.3%.However, directly measured BMI data are considered more accurate than self-reported data, whichmay underestimate the actual prevalence <strong>of</strong> <strong>obesity</strong> given the tendency <strong>of</strong> respondents to over-<strong>Bariatric</strong> <strong>treatments</strong> <strong>for</strong> <strong>adult</strong> <strong>obesity</strong> – March 2012 9
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- Page 74 and 75: REFERENCES1. 2006 Canadian clinical
- Page 76 and 77: 34. Gostin LO. Fast and supersized:
- Page 78 and 79: 69. Klarenbach S, Padwal R, Wiebe N
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141. Ross R, Bradshaw AJ. The futur
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172. Arkinson J, Ji H, Fallah S, Pe
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This section will address a set of
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dietary therapy is to reduce total
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Additional benefits of exercise ove
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medications that inhibit intestinal
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Rimonabant may be considered for pa
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Long-term complications are specifi
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Devices used for bariatric surgeryH
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Description of the Included Systema
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AEs for sibutramineAs compared to a
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Evidence on Efficacy/EffectivenessW
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Table T.7: Effects of behavioural t
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SurgeryDescription of the included
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follow-up time was 3 years. Results
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group as compared to the VBG group.
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The authors identified many methodo
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The investigators pointed out that
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approximately 3 to 5 kilograms. For
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for studies with a mean age of part
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Examining whether use of any of the
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Evidence from placebo-controlled cl
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colorectal or gastroesophageal or f
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Web of ScienceISI Interface License
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AMA Clinical PracticeGuidelineswww.
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critical appraisal of the included
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APPENDIX T.B: EXCLUDED STUDIESTable
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Padwal R, Li SK, Lau DC. Long-term
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Quality subsection 1: At least MEDL
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Quality subsection 5a:Study quality
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Partially reported: The study types
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Table T.C.1: Results of quality ass
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Table T.C.1: Results of quality ass
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APPENDIX T.D: CHARACTERISTICS OF SY
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Table T.D.1: Characteristics of the
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Table T.D.1: Characteristics of the
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Table T.D.2: Characteristics of the
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APPENDIX T.E: EVIDENCE TABLE ON SAF
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Serious surgical complicationsSurgi
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LSGmMAMDNAnssORQoLRCTRDRRRYGBSBPTGV
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Table T.F.1-2: Weight loss - Behavi
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Table T.F.1-4: Weight loss - Surger
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Table T.F.2: Quality of life (QoL)
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Curioni & Lourenco 2005 58Cholester
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Table T.F.3-3: Risk factors/comorbi
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Table T.F.3-5: Long-term effects of
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Maciejewski et al., 2005 65Avenell
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Table T.G.2: Effects of bariatric s
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Table T.G.4: Effects of bariatric s
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18. Cerulli J, Lomaestro BM, Malone
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50. Health Canada Drug Product Data
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SECTION THREE: ECONOMIC EVALUATIONC
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Definition of bariatric surgical pa
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etween surgical interventions, the
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concluded that adding orlistat to L
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Weight management program (WMP) ver
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groups. Compared with standard care
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Results from Analysis of Provincial
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DiscussionThe objectives of the eco
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surgical suites, and so on. The bud
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APPENDIX E.A: LITERATURE SEARCH SUM
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CRD Databases(DARE, HTA & NHS EED)h
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Web of ScienceISI Interface License
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NEOS Librarywww.library.ualberta.ca
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Table E.A.2: Evidence table of revi
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ResultHealth outcomesCostsMarginal
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CostsMarginal analysisThe cost anal
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Time Horizon/discount rateCurrency/
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Objectivestudy perspective: society
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ResultHealth outcomesCostsMarginal
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ResultHealth outcomesCostsMarginal
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S4Economic burden of obesityMean co
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15. Lacey LA, Wolf A, O'shea D, Ern
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Author Contribution StatementsPaula