Bariatric treatments for adult obesity - Institute of Health Economics

Table T.F.3-4: Risk factors/Comorbidities – SurgeryStudyKlarenbach et al., 2010 38Colquitt et al., 2009 62Risk factor/comorbiditiesSurgery versus another surgery or standard care (diet and exercise)Six trials (3 to 100 pts depending on the comorbidity) reported resolution or improvement in comorbidity (participants without pre-existingcomorbidity at baseline were excluded in the analysis). All risk differences were not statistically significant, and these analyses were not informativebecause of low power. No trials reported the incidence of knee or hip replacement.Laparoscopic versus open surgeryOne trial on RYGB patients reported resolution or improvement in comorbidity.Significantly greater resolution of diabetes with open surgery group, as compared to laparoscopic group (RD 50%; 95% CI: 89 to 11; one trial).Significantly greater resolution of dyslipidemia in laparoscopic group, as compared to open surgery group (RD 50%; 95% CI: 84 to 16; one trial).Surgery versus non-surgical treatmentOne RCT of patients with type 2 diabetes found significantly higher remission of the disease following LAGB than conventional therapy, and twoRCTs reporting metabolic syndrome found significantly fewer people with the syndrome 2 years after surgery.Comparison of different surgeriesLRYGB versus LAGBSimilar between the two groups.Open versus laparoscopic proceduresOpen versus laparoscopic gastric bypassOne RCT reported that improvement in comorbidities were similar between the two groups.Bariatric treatments for adult obesity 147