• have multiple focal points and levels <strong>of</strong> intervention (that is, at national, regional, community,and individual levels);• include both policies and programs;• build links between sectors that may otherwise be viewed as independent.Although the primary goal should be to prevent <strong>obesity</strong>, it appears that a large number <strong>of</strong> <strong>adult</strong>sworldwide could benefit from comprehensive assessments to identify those who are at risk <strong>of</strong>developing <strong>obesity</strong> as well as those who are obese and at high risk <strong>for</strong> associated adverseconsequences.Screening and diagnosis <strong>of</strong> <strong>adult</strong> <strong>obesity</strong>According to best practice recommendations in cases <strong>of</strong> overweight and <strong>obesity</strong>, BMI and waistcircumference measurements can function both as screening and as diagnostic tests <strong>for</strong> weightoutside the normal range. 1,2,6,7,13,22,27,80,108The diagnostic protocols are composed <strong>of</strong> physical examination, laboratory tests, psychologicalassessments, and a comprehensive evaluation <strong>of</strong> medical history. 1,2,6,7,13,27,108,109 The medical evaluationentails a complete history (eating patterns, behavioural patterns, physical activity, weight history,attempts at weight loss, and <strong>obesity</strong>-related risk factors and complications) and a physicalexamination (including BMI and waist circumference measurements), as well as appropriatelaboratory and diagnostic testing. During physical examination it is recommended that the presenceand impact <strong>of</strong> <strong>obesity</strong>-related health risks and diseases be assessed.The 2006 Canadian guidelines on diagnosis and management <strong>of</strong> <strong>obesity</strong> recommend: 1measuring BMI and waist circumference in all <strong>adult</strong>s to assess <strong>obesity</strong>-related health risks;conducting a a clinical evaluation <strong>of</strong> obese <strong>adult</strong>s that includes a history and a generalphysical examination to exclude secondary (endocrine or syndrome-related) causes <strong>of</strong> <strong>obesity</strong>and <strong>obesity</strong>-related health risks and complications;measuring fasting plasma glucose levels and determining a lipid pr<strong>of</strong>ile, including totalcholesterol, triglycerides, LDL cholesterol, HDL cholesterol, and calculating the ratio <strong>of</strong> totalcholesterol to HDL cholesterol (repeating these tests at regular intervals as needed issuggested);conducting a psychological assessment:o to determine the person's readiness to change behaviours;o to identify barriers to weight loss;o to screen <strong>for</strong> eating and psychiatric disorders.The guidelines reference the International Diabetes Federation (IDF) cut-<strong>of</strong>f points <strong>for</strong> waistcircumference, given that these measures better reflect the ethnic diversity <strong>of</strong> Canada. 1,3,94 Using IDFcriteria, over 50% <strong>of</strong> Canadians are considered abdominally obese.Management <strong>of</strong> <strong>adult</strong> <strong>obesity</strong>Effective management <strong>of</strong> <strong>adult</strong> <strong>obesity</strong> is multifaceted and complex and involves a range <strong>of</strong> longterm,if not lifelong, bariatric strategies. 1,2,6,7,13,17,21,27,46,50,56,80,82,83,105,106 The therapeutic approach to longtermweight management requires a specially adapted bariatric treatment structure that is tailored to<strong>Bariatric</strong> <strong>treatments</strong> <strong>for</strong> <strong>adult</strong> <strong>obesity</strong> 18
the obese individual, as well as the availability <strong>of</strong> a multidisciplinary team (which may includephysicians, nurses, dietitians, physiotherapists, psychologists/psychiatrists, counsellors, aestheticians,and surgeons). The choice <strong>of</strong> bariatric treatment depends on the individual’s age, gender, level <strong>of</strong><strong>obesity</strong>, overall health condition (individual health risks, existing comorbidities, functionallimitations and ability to exercise, and psychobehavioural characteristics), and readiness andmotivation to make lifestyle and behavioural changes. Long-term, if not lifelong, follow-up andcontinued supervision are necessary to prevent weight regain, monitor disease risks, and manage comorbidities.Current evidence-based clinical practice guidelines (CPGs) recommend measuring an index <strong>of</strong>abdominal fat (waist circumference) in addition to BMI to identify the obese <strong>adult</strong>s in the highestcardiometabolic risk category and guide the use <strong>of</strong> bariatric treatment options (see Table S.3)(www.iotf.org, accessed 23 July 2010). 1,2,13,18,21,22Table S.3: Classification <strong>of</strong> body weight and risk <strong>of</strong> health problems by BMI and waistcircumference 1,2,6,13,20-22,27,35Measure Classification Risk <strong>of</strong> health problemsBMI, kg/m 2< 18.518.5 – 24.925.0 – 29.9UnderweightNormal weightOverweightIncreasedLeastIncreased> 30 Obese30.0 – 34.935.0 – 39.9> 40.0Class I (mild) <strong>obesity</strong>Class II (moderate) <strong>obesity</strong>Class III (severe/extreme or clinical) <strong>obesity</strong>Moderate to highVery highExtremely highWaist circumferenceMen< 102 cm (40 in)> 102 cm (40 in)LowerIncreasedWomen< 88 cm (35 in)> 88 cm (35 in)LowerIncreasedHowever, the practice <strong>of</strong> using only BMI and waist circumference measurements to predict anunfavourable cardiometabolic pr<strong>of</strong>ile has been recently discussed and criticized. 1,5,26,36,106 Currentclassifications <strong>of</strong> <strong>obesity</strong> have limitations when applied in clinical practice because they do notprovide in<strong>for</strong>mation on the presence or extent <strong>of</strong> <strong>obesity</strong>-related health risks, comorbidities, orfunctional limitations that would guide an individual’s decisions. 1,5,22,26,30,36 These classifications arederived from health risk assessments per<strong>for</strong>med in large, heterogeneous populations, and theapplication <strong>of</strong> BMI and waist circumference measures to predict the development <strong>of</strong> health<strong>Bariatric</strong> <strong>treatments</strong> <strong>for</strong> <strong>adult</strong> <strong>obesity</strong> 19
- Page 1 and 2: Alberta STE ReportBariatric treatme
- Page 3 and 4: Alberta STE ReportBariatric treatme
- Page 5 and 6: EXECUTIVE SUMMARYSocial and System
- Page 7 and 8: Three surgical procedures—adjusta
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- Page 14 and 15: TABLES AND FIGURESSection One: Soci
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- Page 18 and 19: LYMmMAMDMUHCNANHLBINHSNICENIHNNHNPH
- Page 20 and 21: Bariatric physician: a licensed Doc
- Page 22 and 23: High-density lipoprotein (HDL): a f
- Page 24 and 25: Very-low-calorie diet (VLCD): a die
- Page 26 and 27: Additional Internet searches were c
- Page 28 and 29: This report addresses obesity in ad
- Page 30 and 31: Many systemic factors have been ide
- Page 32 and 33: Severe obesity is associated with d
- Page 34 and 35: eport their height and under-report
- Page 36 and 37: Also using self-reported data from
- Page 38 and 39: An examination of overall obesity d
- Page 40 and 41: Table S.2 presents the associationa
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- Page 50 and 51: directly causes death. 61 To the ex
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- Page 54 and 55: lack of formal training in nutritio
- Page 56 and 57: slightly more likely to have prescr
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- Page 60 and 61: Barriers to using appropriate baria
- Page 62 and 63: Overview of adult obesityOver the p
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- Page 66 and 67: phenylpropanolamine/25. Sibutramine
- Page 68 and 69: Complianceand AdherenceDemand andut
- Page 70 and 71: Aetna Clinical PolicyBulletinswww.a
- Page 72 and 73: Overweight 123,821 172,971 157,623
- Page 74 and 75: REFERENCES1. 2006 Canadian clinical
- Page 76 and 77: 34. Gostin LO. Fast and supersized:
- Page 78 and 79: 69. Klarenbach S, Padwal R, Wiebe N
- Page 80 and 81: 105. Hill JO, Thompson H, Wyatt H.
- Page 82 and 83: 141. Ross R, Bradshaw AJ. The futur
- Page 84 and 85: 172. Arkinson J, Ji H, Fallah S, Pe
- Page 86 and 87: This section will address a set of
- Page 88 and 89: dietary therapy is to reduce total
- Page 90 and 91: Additional benefits of exercise ove
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medications that inhibit intestinal
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Rimonabant may be considered for pa
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Long-term complications are specifi
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Devices used for bariatric surgeryH
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Description of the Included Systema
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AEs for sibutramineAs compared to a
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Evidence on Efficacy/EffectivenessW
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Table T.7: Effects of behavioural t
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SurgeryDescription of the included
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follow-up time was 3 years. Results
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group as compared to the VBG group.
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The authors identified many methodo
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The investigators pointed out that
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approximately 3 to 5 kilograms. For
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for studies with a mean age of part
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Examining whether use of any of the
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Evidence from placebo-controlled cl
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colorectal or gastroesophageal or f
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Web of ScienceISI Interface License
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AMA Clinical PracticeGuidelineswww.
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critical appraisal of the included
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APPENDIX T.B: EXCLUDED STUDIESTable
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Padwal R, Li SK, Lau DC. Long-term
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Quality subsection 1: At least MEDL
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Quality subsection 5a:Study quality
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Partially reported: The study types
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Table T.C.1: Results of quality ass
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Table T.C.1: Results of quality ass
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APPENDIX T.D: CHARACTERISTICS OF SY
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Table T.D.1: Characteristics of the
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Table T.D.1: Characteristics of the
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Table T.D.2: Characteristics of the
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APPENDIX T.E: EVIDENCE TABLE ON SAF
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Serious surgical complicationsSurgi
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LSGmMAMDNAnssORQoLRCTRDRRRYGBSBPTGV
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Table T.F.1-2: Weight loss - Behavi
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Table T.F.1-4: Weight loss - Surger
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Table T.F.2: Quality of life (QoL)
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Curioni & Lourenco 2005 58Cholester
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Table T.F.3-3: Risk factors/comorbi
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Table T.F.3-5: Long-term effects of
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Maciejewski et al., 2005 65Avenell
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Table T.G.2: Effects of bariatric s
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Table T.G.4: Effects of bariatric s
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18. Cerulli J, Lomaestro BM, Malone
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50. Health Canada Drug Product Data
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SECTION THREE: ECONOMIC EVALUATIONC
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Definition of bariatric surgical pa
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etween surgical interventions, the
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concluded that adding orlistat to L
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Weight management program (WMP) ver
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groups. Compared with standard care
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Results from Analysis of Provincial
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DiscussionThe objectives of the eco
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surgical suites, and so on. The bud
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APPENDIX E.A: LITERATURE SEARCH SUM
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CRD Databases(DARE, HTA & NHS EED)h
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Web of ScienceISI Interface License
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NEOS Librarywww.library.ualberta.ca
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Table E.A.2: Evidence table of revi
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ResultHealth outcomesCostsMarginal
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CostsMarginal analysisThe cost anal
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Time Horizon/discount rateCurrency/
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Objectivestudy perspective: society
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ResultHealth outcomesCostsMarginal
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ResultHealth outcomesCostsMarginal
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S4Economic burden of obesityMean co
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15. Lacey LA, Wolf A, O'shea D, Ern
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Author Contribution StatementsPaula