Haematologica 2004;89: supplement no. 8 - Supplements ...

XVIII Congress of the Italian Society for Hemostasis and Thrombosis Research, Rome, Sept. 30-Oct. 3, 2004131PostersTHROMBOSIS & CANCERPO-072PROCOAGULANT STATE IN CANCERMoniello G, Silvestri A, Tirelli P, De Lucia D,*Mazo S, Passariello N, Gambardella ADepartment of Geriatric Medicine and MetabolicDisease, Second University of Naples: *Institute ofGeneral Pathology and Oncology, Second Universityof Naples, ItalyIn cancer, mostly in metastatic cancer, are commoncomplications as thrombosis and disseminatedintravascular coagulation. Our purpose was to investigatethe coagulation parameters in cancer. We haveenrolled 39 cancer patients (20 male, 19 female, 55+ 4), subdvided in two groups. Group A consisted of18 patients with metastatic cancer (11 M, 7 F, age57±3 years): 6 with non-small cell Lung cancer, 3with pancreatic cancer, 3 with colon-rectal cancer,2 with Gastric cancer, 2 with Head-neck cancer and2 with Breast cancer. Instead, in group B there were21 patients who underwent a surgical treatment (12F, 9 M, age 54±4 years)s: 8 with breast cancer, 5 withcolon-rectal cancer, 3 with non-cmall cell lung cancer,3 with Head-Neck cancer and 2 with kidney cancer.Inboth groups we measured PT, APTT, fibrinogen,AT III, PC, PS, APC resistance, fibrinolytic system andactivation peptides (D-dimer, prothrombin fragment1+2/F1+2).The results were compared with healtycontrol group C (21 female, 17 male, age 53±4). Ingroup C we have found lower levels of fibrinogen, D-dimer and F1+2 than group A (p< 0,01) and group B(p