Haematologica 2004;89: supplement no. 8 - Supplements ...

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XVIII Congress of the Italian Society for Hemostasis and Thrombosis Research, Rome, Sept. 30-Oct. 3, 2004191PO-190FAILURE OF UMBILICAL-RELATED CORD BLOOD STEMTRANSPLANTATION TO CORRECT HEMOPHILIA ABruno G, Cerneca F, Andolina MIstituto per l'Infanzia IRCCS Burlo Garofolo, Trieste,ItalyIf the hematopoietic stem cells or the mesenchimalof bone marrow were able to mature intoendothelial cells, a bone marrow transplantationcould theoretically cure haemophilia A. We reportthe case of a child whose outcome seems to rule outthis hypothesis. A 6 year old child, suffering fromboth hemophilia A (Factor VIII:c
192PostersPO-192SENSIBILITY OF THE PROTHROMBIN TIME (PT) ANDACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT)IN THE EVALUATION OF COAGULATION FACTOR DEFICIENCYCau C, Rolla R, Albertario M, Bellomo G,Pergolini PLaboratorio di Ricerche Chimico-Cliniche,Università del Piemonte Orientale, ASO Maggioredella Carità, Novara, ItalyCongenital or acquired coagulation factor deficiencypromotes hemorrhagic disorders. The prothrombintime (PT) and activated partial thromboplastintime (APTT) are global screening proceduresprimarily employed to evaluate coagulation abnormalitiesin the intrinsic or extrinsic pathway respectively.Deficiency in any of the factors involved inthe extrinsic or intrinsic pathways results in a prolongedthromboplastin time (PT) or in a prolongedpartial thromboplatin time (APTT). Aim of the presentstudy was to investigate the sensibility of bothThromborel S reagent/BCS instrument and Actin/FSreagent/BCS instrument (Dade Behring) in the evaluationof coagulation factor deficiency using PT andAPTT as revealing tests. A pool human plasmaobtained from 20 healthy donors was diluted in commerciallyavailable plasma deficient in factors V, VII,X, VIII and IX, in order to obtain 10, 15, 20, 25, 30,35, 40, 50, 60, 70, 80 90% decrease of the originalactivity (100%). PT (INR) or APTT (sec) determinationswere performed at any reported dilution usingThromborel S Reagent (factors V, VII and X) or ActinFS reagent (factors VIII, IX). A prolongation of the PT(increase in INR) or APTT above the normal rangewas considered as the lower detection limit for possiblecoagulation factor deficiency. The resultsobtained are reported in the following tableCoagulation factor Normal range APTT (22-33 sec) PT (0.8-1.2 INR) Residual activityFV (70-120%) 1.22 55%FVII (70-120%) 1.22 60%FX (70-120%) 1.22 55%FVIII (70-150%) 33.5 69%FIX (70-120%) 33.5 60%Dade Thromborel S reagent, Actin FS reagent andBCS intrument exhibit a high degree of sensibilityfor the investigated factors of the extrinsic (V, VII, X)and intrinsic (VIII, IX) coagulation pathway. Thedetection of abnormally high PT-INR or APTT mightresult from the occurrence of as low as 45% decreasein single factor activity.haematologica vol. 89(suppl. n. 8):september 2004
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haematologicaThe origin and power o
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XVIII Congress of the Italian Socie
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XVIII Congress of the Italian Socie
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2Educational Sessionssurgery. In av
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4Educational Sessionsclinical relev
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6Educational SessionsTREATMENT OF S
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8Educational Sessionssioners, aceno
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10Educational Sessionshaematologica
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94PostersU/dL respectively. Convers
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96Postersreport showing the presenc
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98PostersPO-008INTEGRIN α2β1 AND
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100Postersthe International Society
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102PostersPO-017GASTROINTESTINAL BL
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104PostersPO-021EVALUATION OF A NOV
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106PostersVWF-LIA appears to be at
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108PostersIn our hospital the routi
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110PostersPO-032GENETIC RISK FACTOR
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112PostersPO-036CATASTROPHIC VASCUL
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114Postersprostanoide intravenously
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116Posters5 mg folic acid daily, pl
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118Postersrelated to an acute infla
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120Postersexplanation of the increa
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122Postersgonadal hormone replaceme
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124Posters§Department of Nephrolog
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126PostersPostersWOMEN'S HEALTH ISS
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128Postersexcess of the anticoagula
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130PostersC (APC- Resistance). The
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132Postersgene substitution may be
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136Postersthe increased DVT risk as
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138Postersinternal jugular vein thr
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