Haematologica 2004;89: supplement no. 8 - Supplements ...

162Postersfirst VTE episode were enrolled and prospectively followed-upto estimate mortality, recurrences and longterm sequelae (pulmonary hypertension and postthromboticsyndrome). Results. 1282 patients wereenrolled (729 male / 553 female, mean age 70 years,range 18 – 96) with estimated incidence in the generalpopulation of 1.07 cases/1,000/year. The maincharacteristics of study population are shown in thetable.DVT DVT+PE Isolated Massive Unusual Idiopathic Surg/Orthp.PE PE Site VT VTE VTE(or RVD)558 210 448 97 66 610 358Cancer Intern./CO Recurrent Cr.Pulm. Fatal Total MajorVTE VTE VTE Hypert. PE Deaths Bleedings279 148/30 163 17 29 129 32Conclusions. During the seven years of follow-upwe observed a steadiness in VTE incidence rate, withsignificant reduction both in incidence and in deathrate massive-PE related. Cancer-VTE increased withconsistent effect on late recurrence, mortality andhemorrhagic events.PO-133INCIDENCE OF POSTOPERATIVE PULMONARY EMBOLISMDETECTED BY MULTI-SLICE COMPUTERIZED TOMOGRAPHYIN LUNG SURGERY FOR CANCERMilillo G, Daddi G, lupattelli L, Ragusa M, Lemmi A,Puma F, lomonaco A, Agnelli G for The PulmonaryEmbolism In Thoracic Surgery (PETS) Study GroupDivisions of Internal and CardiovascularMedicine,Thoracic Surgery and Radiology,University of Perugia, ItalyThe incidence of pulmonary embolism (PE) inpatients undergoing lung surgery for cancer remainsundefined. In these patients the risk for venous thromboembolismis potentially high due to the combinationof prothrombotic effects of cancer, extensivesurgery, prolonged immobilization and parietal andendothelial local alteration consequent to surgery. Theaim of this study was to assess the incidence of PEafter lung surgery for cancer using multi-slice computerizedtomography (MSCT). Methods: Consecutivepatients undergoing surgery for lung cancer wereincluded in this study. PE was detected by MSCT (GELight-Speed 4×1,25) scan performed 7-15 days aftersurgery. Diagnostic criteria for PE were complete orpartial intraluminal filling defect. Patients werescheduled to receive pharmacological prophylaxis forvenous thromboembolism with low-molecular-weightheparin (LMWH) starting the first post-operative dayand continued until discharge. Results: Fifty patientswere included in this study. The average age was 66,5(range 26 to 90). Diagnosis of cancer was confirmedin all except one patient found to be affected bytuberculosis. Thirty-six patients underwent lobectomy,11 pneumonectomy, and the remaining 3 patientswedge resection. Histology showed epidermoid carcinomain 20 cases, adenocarcinoma in 15, anaplasticcarcinoma in 7, and other types in the remaining 8cases. All patients but two received prophylaxis forvenous thromboembolism. Seven patients (14%)showed PE at MSCT scan. Of the PE, 5 involved centralarteries (principal, lobar and segmentary) and 2subsegmentary arteries. Two of the patients withMSCT scan detected PE were symptomatic. PE is acommon complication in patients undergoing lungsurgery for cancer, despite antithrombotic prophylaxis.In such high-risk population prophylactic regimensshould be optimized.PO-134CARDIOVASCULAR RISK FACTORS AND THE RISK OF VENOUSTHROMBOEMBOLISMTufano A, Varricchione N, Coppola A, Cirillo F,De Simone C, Meola M, Lombardini D,Sidiropulos M, Albisinni R, Cerbone AMRegional Reference Centre for Coagulation Disease,Dep. of Clinical and Experimental Medicine;Federico II University, Naples, ItalyThe association between established cardiovascularrisk factors and the risk of venous thromboembolism(VTE) is not entirely understood. We havescreened for cigarette smoking, hypertension, hypercholesterolemia,diabetes mellitus, obesity, andhyperhomocysteinemia 397 consecutive patients(172 men and 225 women; 42.69±14.89 yrs) referredto our Centre because of recently documented venousthromboembolic events (deep venous thrombosisand/or pulmonary embolism, and venous thrombosisin abdominal veins, and cerebral vein thrombosis). Asmany as 407 age- and sex-matched apparentlyhealthy subjects (164 men and 243 women;39.53±13.57 yrs), from the same ethnic backgroung,served as controls. Arterial hypertension was presentin 18.5% of VTE patients and in 12.8% of controls(p=0.026; OR 1.5, 95% CI 1.1-2.3). Hypercholesterolemia(total cholesterol levels >5.2 mmol/L inrepeated evaluations over a 1-yr period) was morecommon in VTE patients than in controls (53.6% vs.39.1%, p=0.001, OR 1.8, 95% CI 1.3-2.5), as was BMI>25 (59.5% vs 40.4%; p