Haematologica 2004;89: supplement no. 8 - Supplements ...

XVIII Congress of the Italian Society for Hemostasis and Thrombosis Research, Rome, Sept. 30-Oct. 3, 200483follow-up is currently available in 897 patients(60.7%) at 6 months, 562 patients (38%) at 12months and 67 patients (4.5%) at 24 months. Duringfollow-up 146 events were recorded: 18 VTErecurrences at 6 months and 18 at 12 months; 15bleeding episodes at 6 months and 4 at 12 months;8 new-diagnosed cancer at 6 months and 4 at 12months; 2 myocardial infarction at 6 months and 2at 12 months; 2 strokes at 6 months; 21 deaths at 6months and 15 at 12 months. Conclusions: The VTEpopulation enrolled in this registry appears to be representativeof the broad spectrum of VTE patients.The long-term follow-up will allow to better understandingthe long-term clinical course of VTE and tooptimize and standardize its management.SISET PrizeCO-121PREVALENCE OF SYMPTOMATIC AND ASYMPTOMATICATHEROSCLEROSIS IN PATIENTS WITH IDIOPATHICDEEP-VEIN THROMBOSISSartor D, Petrobelli F, Hartman L, Concolato A,Bilora F, Pagnan A, Prandoni PDipartimento di Scienze Mediche e Chirurgiche,Università di Padova, ItalyBackground. Recently, an association has beendescribed between atherosclerosis and venous thrombosis,suggesting that either atherosclerosis mayinduce venous thrombosis or the two conditions mayshare common risk factors. Aim. To assess whether theprevalence of symptomatic and asymptomatic atherosclerosisin patients with idiopathic deep-vein thrombosis(DVT) is higher than that of patients with thrombosissecondary to known risk factors. Patients andMethods. Out of 180 patients over 50 years who hadsuffered an episode of DVT, alone or associated withpulmonary embolism, between 2000 and 2003, 140were retrieved who fulfilled the study criteria. Of them31 (22.1%) had a history of multiple thromboticepisodes, and 23 (16.4%) were carriers of thrombophilia.At referral, they received an interview withemphasis to previous symptomatic atherosclerosis(coronary artery disease, ischemic stroke, or artheriopathiesof the lower limbs). Then, they underwentthe bilateral ultrasound assessment of carotid arteriesto evaluate the presence of vessel wall plaques.Results. Of the 140 patients, 79 (56.4%) were labeledas having an idiopathic DVT, while in the remaining 61the thrombosis was associated with a known risk factor.The prevalence of symptomatic atherosclerosis inpatients with idiopathic DVT (27/79; 34.2%) was higherthan that observed in patients with secondary DVT(16/61; 26.2%). At least one carotid plaque wasdetected in 52 of the 79 patients (65.8%) with spontaneousthrombosis, and in 32 of the 61 (52.5%) withsecondary thrombosis. The OR for symptomatic atherosclerosisand/or carotid plaques in patients withspontaneous as compared to secondary thrombosiswas 2.0 (95% CI, 1.0 to 3.9). In a multivariate analysistaking into account age, risk factors for atherosclerosis,thrombophilia, and history of previousthrombosis the strength of the association did notchange. Conclusions. The results of this study, conductedin a wide series of patients with symptomaticDVT older than 50 years (including patients with symptomaticatherosclerosis and/or multiple thromboticepisodes), confirm the existence of an associationbetween atherosclerosis and idiopathic venous thrombosis.CO-122ANTITHROMBOTIC PROPHYLAXIS DURING PREGNANCY INWOMEN WITH PREVIOUS VENOUS THROMBOEMBOLISMMartinelli I, Battaglioli T, Mannucci PMAngelo Bianchi Bonomi Hemophilia and ThrombosisCenter, Department of Internal Medicine and Dermatology,Istituto di Ricovero e Cura a CarattereScientifico Ospedale Maggiore Policlinico, Universityof Milan, ItalyPregnancy enhances the risk of venous thromboembolism(VTE). Although previous episodes of VTEare considered risk factors for recurrence, womenwith previous VTE seem to have a low risk for recurrenceduring pregnancy. Therefore, whether or notthey may benefit from antithrombotic prophylaxis isnot established. Thrombosis during pregnancy mayalso involve the placental circulation, resulting inobstetrical complications, such as fetal loss, preeclampsiaand intrauterine growth restriction. Aimsof the study were: i) to assess the efficacy of prophylaxiswith low molecular weight heparin (LMWH)during pregnancy in women with previous VTE. ii) toassess the same regimen in preventing obstetricalcomplications. Sixty women with previous VTE whounderwent a thrombophilia screening were prospectivelyfollowed in 74 pregnancies. Twenty-twowomen without thrombophilia were followed for 28pregnancies and 38 with thrombophilia (3 proteinC-, 1 protein S-, 1 antithrombin-deficiency, 16 factorV Leiden, 10 prothrombin mutation, 1 antiphospholipidantibodies) for 46 pregnancies. Forty-sixpregnancies (32 in women with and 14 in womenwithout thrombophilia) were treated with LMWHfrom the first trimester and 28 (14 in women withand 14 in women without thrombophilia) were not.Two recurrences of VTE during pregnancy, both inwomen with thrombophilia, were observed in thehaematologica vol. 89(suppl. n. 8):september 2004