Haematologica 2004;89: supplement no. 8 - Supplements ...

XVIII Congress of the Italian Society for Hemostasis and Thrombosis Research, Rome, Sept. 30-Oct. 3, 2004159patients (4/20; 20%) had the G20210A FII allele variant.This frequency was 4-fold higher (p=0.025 Fisher'stest; OR 4.57, CI 1.4-15.2) than that of healthycontrols (17/328; 5.2%). The frequency of the FactorV Leiden allele was 10% (2/20) in patients and almosthalf (5.8%, 19/328) in controls (p=0.34, Fisher's test).In contrast, the frequency of the omozygosity forMTHFR was 20% (4/20) in patients and 18.3%(60/328) in controls (p=0.75), and hyperhomocysteinemia(HHcy) was 19% in patients and 28% incontrols (p=0.56 Fisher's test). Within female patients,5 out of 12 developed CVT while using oral contraceptives(41.7%), and 2 out of 12 during pregnancy/puerperium(16.7%). None of the mutationsreported above was present in these 7 cases. Despitethe limitations of the sample size, these data confirmthe role of the G20210A FII mutation as well as ofFactor V Leiden in CVT; they also document that in>1/3 of cases acquired rather than inherited predisposingfactors are present in such patients.PO-128THROMBOPHILIA IN YOUNG ADULTS WITH ISCHEMIC STROKENOT RELATED TO CARDIOVASCULAR RISK FACTORSAnastasio R, Lupo E,* Grimaudo S, Bonifacio G,Malato A, Siragusa S, Mariani G**Cattedra di Ematologia, Azienda OspedalieraUniversitaria Policlinico di Palermo; *Cattedra di Neurologia,Azienda Ospedaliera UniversitariaPoliclinico di Palermo; **Dipartimento di MedicinaInterna e Sanità Pubblica, Università dell'Aquila, ItalyThe role of thrombophilia for causing ischemicstroke in young adults is still debated. During the lastyears several trials investigated the role of prothromboticconditions in this setting reporting discordantresults. During a period of 2 years (2001-2003), weevaluated 73 consecutive patients referred to ourInstitution for an episode of adult ischemic stroke inwhom common cardiovascular risk factors (cigarettesmoking, hypertension, hyperlipidemia and diabete)were not considered as responsible for the disease. Inthis setting of patients, the prevalence of coagulationabnormalities (lupus antiCoagulant –LAC-, deficiencyof anti-thrombin, protein C and protein S, elevatedlevels of FVIII and Fibrinogen, activated protein C resistance–APCR-), genetic prothrombotic risk factors (FVLeiden, FII mutation -G20210A-, C677T and A1298C5,10-methylenetethrahydropholate reductase –MTH-FR-) and fasting and post-methionine loading (PML)serum homocysteine levels were determined. One hundredthirty-eight healthy subject served as controls.The results are shown in the table: the prevalence ofcommon cardiovascular risk factors did not differbetween case and controls.Patients Controls Odds Ratio p value(95% ConfidenceIntervals)No. of patients (M/F) 73 (38/35) 138 (66/72) n.s.Mean age, y. 37.6±10.9 38.8±11.3 n.s.Age at the first event 33.7 ±10.2Risk factorsCigarette smoking 31.2% 28.7% 1.1 (0.6-1.6) n.s.Hypertension 11.4% 8.6% 1.3 (0.5-2.1) n.s.Hyperlipidemia 7.3% 6.5% 1.1 (0.2-2.0) n.s.Diabetes 1.9% 1.4% 1.4 (0.5-2.1) n.s.ThrombophiliaLAC 6.8% 1.4% 4.9 (1.7-8.19)