Haematologica 2004;89: supplement no. 8 - Supplements ...

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XVIII Congress of the Italian Society for Hemostasis and Thrombosis Research, Rome, Sept. 30-Oct. 3, 200473ic diseases. Results. The prevalence of the 10ins allelewas not different between Italians and Mixed-Italiansand between Belgians and Mixed-belgians, andwas higher in Italians in comparison with Belgians(p=0.0054) (see Table).Oral CommunicationsHOMOCYSTEINE &ANTIPHOSPHOLIPID ANTIBODIESFVII levels were higher in subjects without the10ins allele, in all three populations (p
74Oral Communicationsmorphism, but not in those with folic acid ≥5 nmol/L.Among all the possible combinations of the 3 analyzedpolymorphisms, the more frequent combinedgenotypes resulted 677CT/1298AC/2756AA (28.6%),677TT/1298AA/2756AA (19.6%) and 677CT/1298AA/2756AA (16.7%). Homocysteine levels were significantly(p0.05). Atthe multivariate logistic regression analysis adjustedfor age, sex, creatinine plasma levels, folate, B6and B12 plasma levels, folate and B6 intakes andMTHFR polymorphism, eNOS gene polymorphismswere not significantly associated with an increasedrisk of having high levels of homocysteine. Nevertheless,as far as subjects with lowest serum folatetertile are considered, only eNOS -786C variant influencedthe risk of being in the highest homocysteinetertiles (2 nd tertile: OR 6.4, p=0.02; 3rd tertile: OR8.3, p=0.01). Our results document a possible associationbetween eNOS T-786C polymorphism andhomocysteine plasma levels in healthy subjects withlow serum folate levels.CO-104A PROINFLAMMATORY STATE INDICATED BY HIGH IL-6LEVELS IS RELATED TO HYPERHOMOCYSTEINEMIAGori AM, Fedi S, Corsi AM,* Rogolino A,^Alessandrello Liotta A,^ Gazzini A, Lenti M, Poggi F,Rossi L, Ferrucci L,** Abbate R, Gensini GFDepartment of Medical and Surgical Critical Area,University of Florence; *Laboratory of ClinicalEpidemiology, Geriatric Department, National Instituteof Research and Care on Aging (INRCA), Florence;^Dipartimento Cardiologico e dei Vasi, AziendaOspedaliero-Universitaria Careggi, Florence,Italy; **Longitudinal Studies Section, GerontologyResearch Center, National Institute on Aging,National Institutes of Health, Baltimore, USAElevated levels of homocysteine may reflectincreasing age, male sex, renal failure, vitamin deficiencies(low folate, vitamin B12 or vitamin B6), orinherited abnormalities of enzymes involved in themethionine metabolism. Aim of this study was todetermine in a large population based samplewhether hyperhomocysteinemia is associated withhigh circulating levels of inflammatory markers.Westudied 586 men and 734 women randomly selectedfrom the people living in two sites in the surroundingof Florence, Italy. In the InCHIANTI populationhomocysteine, folic acid, vitamin B6 and B12levels were 13.7 (5.4-95.9) µmol/L, 6.3 (0.7-45.3)nmol/L, 25.3 (0.4-689.2) nmol/L and 285 (25.2-1488.1) pmol/L respectively. Dietary vitamin B6 andfolic acid intakes were strongly (p
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haematologicaThe origin and power o
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XVIII Congress of the Italian Socie
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XVIII Congress of the Italian Socie
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2Educational Sessionssurgery. In av
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4Educational Sessionsclinical relev
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6Educational SessionsTREATMENT OF S
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8Educational Sessionssioners, aceno
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10Educational Sessionshaematologica
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12Selected Oral Communicationsleste
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14Selected Oral Communications11-84
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16Selected Oral Communicationssis,
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18Selected Oral CommunicationsSISET
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20Oral CommunicationsCO-002LYSOSOMA
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Page 103 and 104: 94PostersU/dL respectively. Convers
Page 105 and 106: 96Postersreport showing the presenc
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Page 109 and 110: 100Postersthe International Society
Page 111 and 112: 102PostersPO-017GASTROINTESTINAL BL
Page 113 and 114: 104PostersPO-021EVALUATION OF A NOV
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Page 123 and 124: 114Postersprostanoide intravenously
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Page 127 and 128: 118Postersrelated to an acute infla
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124Posters§Department of Nephrolog
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126PostersPostersWOMEN'S HEALTH ISS
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128Postersexcess of the anticoagula
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130PostersC (APC- Resistance). The
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132Postersgene substitution may be
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134Postersof LMWH or OA for the tre
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136Postersthe increased DVT risk as
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138Postersinternal jugular vein thr
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140PostersPostersANTIPLATELET THERA
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142PostersPO-093MONITORING PLATELET
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144PostersPostersACQUIRED COAGULATI
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146Postersshowed significantly high
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148PostersPO-105PROGNOSTIC SIGNIFIC
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150Postersscreen and SCT confirm we
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152PostersPO-114ECAPS STUDY: MULTIC
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154Postersnary Intensive Therapy Un
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156PostersPO-122GENOTYPE/PHENOTYPE
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158PostersPO-126MATERNAL-FETAL THRO
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160PostersPO-129RISK FACTOR FOR EXT
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162Postersfirst VTE episode were en
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164Postersative salvage and re-infu
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166PostersPO-141CYTOMEGALOVIRUS INF
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168PostersPO-145COMPLETE COMPRESSIO
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170PostersBackground: Acutely ill m
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172PostersPostersORAL ANTICOAGULANT
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174PostersPO-156DIAGNOSTIC EFFICACY
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176PostersPO-159ORAL ANTICOAGULATIO
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178PostersPO-163BLEEDING RISK IN PA
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180PostersHemorrhages represent the
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182Postersma and native whole blood
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184PostersPostersTHERAPY OF HEMOPHI
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186PostersPO-179INHIBITOR DEVELOPEM
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188PostersPO-183PROPOSAL OF IMMUNOT
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190PostersAt the last follow-up, 11
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192PostersPO-192SENSIBILITY OF THE
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Campagna F 11Campagnoli MF 137Campa
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Ieri M 142Iezzi A 11Ilari I 26, 167
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Rotilio D 32, 33Rotoli B 145Rotunno
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Haematologica 2004;89: supplement no. 8 - Supplements ...

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