Haematologica 2004;89: supplement no. 8 - Supplements ...

XVIII Congress of the Italian Society for Hemostasis and Thrombosis Research, Rome, Sept. 30-Oct. 3, 200431Oral CommunicationsTHROMBOSIS & NUTRITION:EXPERIMENTAL & EPIDEMIOLOGICAL STUDIESCO-025COMPARISON OF GLOBAL RISK OF FATAL CARDIOVASCULARDISEASE IN THREE EUROPEAN POPULATIONS: RESULTS FROMTHE IMMIDIET PROJECTDi Castelnuovo A,* Zito F,* Dircks C, # Siani A,°Arnout J, # Cappuccio FP, § Donati MB,* Iacoviello L*on Behalf Of The IMMIDIET Study Group*Laboratory of Genetic and EnvironmentalEpidemiology, Center for High Technology Researchand Education in Biomedical Sciences, CatholicUniversity of Campobasso, Italy; # Center forMolecular and Vascular Biology, University ofLeuven, Campus Gasthuisberg, Leuven, Belgium;§Department of Community Health Sciences,St. George's Hospital Medical School, CranmerTerrace, London, UK; °Institute of Food Sciences,CNR, Avellino, Italy.Background and aim. An increase in global cardiovascular(CVD) risk from southern to northern Europeanpopulations is largely accepted. Recently theThird Joint Task Force of the European Societies onCoronary Prevention and investigators of the SCOREProject proposed a new risk chart for evaluation often-year risk of primary fatal CVD disease in Europe.The estimation models are based on gender, age,total cholesterol (TC), smoking and systolic bloodpressure (SBP). We aimed at investigating the differencesin the risk of fatal CVD using SCORE equationsin three primary care-based European populationsfrom the IMMIDIET project. Methods. TheIMMIDIET Project (Dietary Habit Profile in EuropeanCommunities with Different Risk of MyocardialInfarction: the Impact of Migration as a Model ofGene-Environment Interaction) includes a study on1602 subjects from 3 populations: Italy (N=542),Belgium (N=535) and England (N=525). The subjects,apparently healthy and aged 30-65 years, were freefrom diabetes, CVD or other major chronic diseases.Ten-year CVD risk was calculated applying SCOREequations to IMMIDIET subjects, separately for menand women. Differences among countries have beenadjusted for age and for multiple comparisons.Results. Some characteristics of the subjects areshown in the Table. Italians were the youngest andEnglish the oldest. Prevalence of smokers and SBPlevels were more elevated in Italy as compared withBelgium and England. Belgians showed the highestlevels of cholesterol. Although the prevalence ofindividual risk factors was lower in the English group,the age-adjusted CVD risk in females was higher inEngland (P