Haematologica 2004;89: supplement no. 8 - Supplements ...

166PostersPO-141CYTOMEGALOVIRUS INFECTION AND ACUTE THROMBOSISSquizzato A, Gerdes VEA, Büller HRDepartment of Vascular Medicine, AcademicMedical Center, University of Amsterdam,Amsterdam, The NetherlandsDifferent infectious pathogens have been advocatedas responsible agents for thrombotic disorders.Cytomegalovirus (CMV) is one of the infectiousagents supposed to play a role in apparently unprovokedacute thrombosis. In vitro studies show a clearprocoagulant influence of CMV, either directly or byinfection of endothelial cells and monocytes. However,the frequency of thrombotic complications inCMV-infected patients is unknown, since welldesignedstudies are lacking. METHODS. We performedan extensive search in the all-languages literaturethroughout the MEDLINE and EMBASE databases,utilizing the terms of cytomegalovirus, CMV,and thrombosis to identify all published case reportsof acute thrombosis occurring during an acute CMVinfection. A detailed review of the references completedthe search. We identified 36 cases of acutethrombosis in patients with acute CMV infection, 15in immunocompromised and 21 in immunocompetentpatients. Venous thrombosis was present in 29patients, arterial thrombosis in 9, and both in 2.Mean age was 39.3 years (range: neonatal to 74),and 66% of the patients was male. HIV infection waspresent in 50% of the immunocompromised patients.A positive association between positive acute CMVinfection serology and early and late hepatic arterialthrombosis after liver transplantation is alsoreported. Our systematic review of case reports indicatesthat thrombosis is a possible and not rare complicationof acute CMV infection. A possible role ofsubclinical CMV infection in apparently unprovokedarterial and venous acute thrombosis is unclear. Adequateprospective studies evaluating the role of CMVas risk factor for thrombosis are warranted.PO-142INCIDENCE OF DEEP VEIN THROMBOSIS IN PATIENTS WITHCOPD AT I AND II STAGE OF GOLD CLASSIFICATIONLessiani G,° Shamasbloo M, Santozzi M, Laglia G,Febo F, Grazziosetto R, Franzone G, Gentili M,D'Amico M, Di Bernardo C,° Feliciani MDepts. of Internal Medicine and Angiology Unit°,Pescara, ItalyThere are increasing data in literature on the roleof the deep vein thrombosis (DVT) as a complicationof numerous medical conditions. Patients group withinternistical deseases presents an intermediate risk(15%). Nevertheless in this group of patients lots ofheterogeneous pathologies are represented. In theCronic Obstructive pulmonary desease (COPD)patients there aren’t till now certain datas. The DVTrisk in patients with COPD fluctuates between valuesof 10%-20%,untill 28% in decompensatedCOPD. Target of our study is to verify with venousultrasonography the presence of DVT, in the affectedpatients from mild-moderate COPD curbedaccording to the GOLD classification. We tested 100consecutive patients, arrived at our institute forexacebation of COPD between Jannuary and May2003 (average : 68.02 years; 61 male and 39 female).All were checked with spirometry, Rx Thorax, bloodgas test to diagnose COPD I-II (A ;B) stadium (GOLDI:1) VEMS/CVF< 70%, 2) VEMS>80% of the abovementioned,3) with or without clinical symptoms.GOLD II:1) VEMS/CVF