Haematologica 2004;89: supplement no. 8 - Supplements ...

XVIII Congress of the Italian Society for Hemostasis and Thrombosis Research, Rome, Sept. 30-Oct. 3, 200471NVAF patients had higher sCD40L values (5.0±1.8 vs2.8±0.8 ng/mL respectively, p15 UI/mLwas present in 74/280 (26.4%) patients compared to25/280 (8.9%). Positivity of anticardiolipin antibodies,defined as levels > 20 UMPL for IgM type and/orUGPL for IgG type), was found significantly moreprevalent in patients than in healthy subjects(p15 UI/mL, ACA positivity and prothrombinvariant) and PAD. Moreover, when high levelsof Lp(a) were associated with another metabolicrisk factor (e.g. HHcy or dyslipidemia) the susceptibilityto the disease resulted to be increased. In conclusion,these results show an association betweenPAD and emerging hemostasis-related risk factors.CO-099ASSOCIATION BETWEEN –675 4G/5G POLYMORPHISM OF THEPAI-1 GENE AND OBESITY IN ITALIAN MEN: LONGITUDINALFINDINGS OF THE OLIVETTI HEART STUDYIacoviello L,* Iacone R,° Farinaro E,°° Versiero M,°Siani A,** Cappuccio F,°°° Donati MB,* Strazzullo P°*Center for High Technology Research and Educationin Biomedical Sciences, Catholic University, Campobasso,°Department of Clinical & °°ExperimentalMedicine, Department of Preventive Medical Sciences,"Federico II" University of Naples MedicalSchool, Naples; **Epidemiology & Population Genetics,Institute of Food Sciences, CNR, Avellino; Italy;°°°Department of Community Health Science, St.Georges' Hospital Medical School, London, UKBackground. Development of obesity is associatedwith extensive remodelling of adipose tissue andinvolves extracellular matrix proteolysis. PAI-1 levelshave been associated with adipose tissue remodelling.PAI-1-deficient mice on high fat diet developedmore rapidly adipose tissue than their leancounterparts while transgenic mice overexpressing astable human PAI-1 variant had virtually no intraperitonealfat. Objective. To investigate the possibleassociation of –675 4G/5G polymorphism of the PAI-1 gene, a genetic variation associated with PAI-1levels, with body mass, body fat distribution and obesity-associatedhypertension in a sample of adultmale population. Methods. The –675 4G/5G polymorphismwas evaluated in a group of 378 participantsof the Olivetti Heart Study seen at the 2001-2003 follow-up visit, who had been examined forthe first time in 1975 (all males, age range 50-81years). Complete anthropometry and blood pressure(BP) were measured with standardised procedures.Results. At the follow-up examination participantshaematologica vol. 89(suppl. n. 8):september 2004