Ahtisham-Ul-Haq, J <strong>Vaccines</strong> Vaccin <strong>2013</strong>, 4:5http://dx.doi.org/10.4172/2157-7560.S1.0163 rd International Conference on<strong>Vaccines</strong> & VaccinationJuly 29-31, <strong>2013</strong> Embassy Suites Las Vegas, NV, USAEffectiveness of BCG vaccination in preventing tuberculosisAhtisham-Ul-HaqService Institue of Medical Sciences, PakistanCommon lower respiratory tract infections include tuberculosis, asthma and chronic obstructive pulmonary disease (COPD).World Health Organization (WHO) defined tuberculosis as an infectious disease caused by Mycobacterium tuberculosiswhich most commonly affects lungs. With increase in prevalence, tuberculosis (TB) is now the second only to AcquiredImmuno-Deficiency Syndrome (AIDS) as the greatest killer worldwide due to a single infectious agent. Bacille Calmette Guérin(BCG) vaccination has been developed against tuberculosis to decrease the mortality from this disease. Although BCG is notcommonly inoculated in America, it is routinely given to infants and children in countries where TB is prevalent. However, casesof tuberculosis have been identified even after inoculation of BCG vaccine. This study was conducted at tuberculosis and asthmaclinic of Children Hospital Lahore from January 2012 to December 2012. All those children were included in the study who metthe selection criteria. Out of 500 children half, 250 (50%) were male while remaining 250 (50%) were females. 227 (45.4%) werediagnosed as having TB on the basis of PPASC. 389 (77.8 %) were vaccinated while remaining 111 (22.2 %) were not vaccinated.Out of 227 children with diagnosis of TB, 91 (39.9%) were male while 136 (59.9%) were females. Out of 389 vaccinated children,132 (33.9%) were diagnosed as having TB while out of 111 non-vaccinated children 95 (85.6%) got TB. Results of the studyindicate that although vaccination with BCG decreases the prevalence of TB however, it is not 100% effective in combating withtuberculosis.BiographyAhtisham-Ul-Haq completed his M.B.B.S at the age of 25 years from Allama Iqbal Medical College. He did his M.P.H. from Institute Of Public Healthin 2004 and is currently enrolled in M.Phil. in Community Medicine. Currently he is working as additional medical superintendant at a well-reputedtertiary care hospital. He has presented his research work at various national and international forums.auhaq31@gmail.comJ <strong>Vaccines</strong> Vaccin <strong>2013</strong>ISSN: 2157-7560, JVV an open access journal<strong>Vaccines</strong>-<strong>2013</strong>July 29-31, <strong>2013</strong>Volume 4 Issue 5Page 82
Teena Mohan et al., J <strong>Vaccines</strong> Vaccin <strong>2013</strong>, 4:5http://dx.doi.org/10.4172/2157-7560.S1.0163 rd International Conference on<strong>Vaccines</strong> & VaccinationJuly 29-31, <strong>2013</strong> Embassy Suites Las Vegas, NV, USAImmunomodulatory functions of defensins, innate molecules, as mucosal adjuvant with thepeptide antigens of HIV-1 at the mucosal surfacesTeena Mohan and D. N. RaoDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, IndiaIntroduction: The mechanisms of resistance to HIV infection in the human oral cavity are incompletely understood whilesalivary components have been implicated in protection. There are growing evidences that human defensin peptides originatingin the oral epithelial cells may be playing an important role in the prevention of HIV infection.Methodology: We have synthesized HIV and Defensin peptides and their corresponding analogues by making some modificationsin the natural sequence. We have done Anti HIV, Anti-microbial and other characteristic study of defensins to prove them active.Then, immunized theses formulations in Outbred and Two different Inbred mice (H 2b , H 2d ) through IN route using Microsphereas delivery vehicle. We have studied Humoral Response of HIV peptides with and without Defensins by estimating antibody levels(IgG/IgA) in the serum as well as in lung, intestinal, vaginal and rectal washes till day 120. For cell mediated immune response,peptide specific T cell proliferation and cytokine/chemokine levels were studied in the cells isolated from the three differentmucosal sites i.e. spleen, lamina propria and peyer’s patches of the primed mice. Simultaneously, we have done Cytolytic activityanalysis, by estimating IFN-γ/Perforin secretion by CD4+ also through FACS, which was checked by IFN- γ/Perforin secretion.Result & Discussion: The HIV peptides alone in microsphere showed low peptide specific response of peak titre in sera anddifferent washes while the presence of defensins increased significantly this titre both in sera (1,02,400-4,09,600) as well as inwashes (800-12,800) (p
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