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Bush__The_Essential_Physics_for_Medical_Imaging - Biomedical ...

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high abundance (94%), their low energy results insignificant patient attenuation, which is particularlydifficult with female patients, in whom breastartifacts in myocardial imaging often makesinterpretation more difficult.Molybdenum-99 (99Mo) Nuclear fission ( 235 U) ~- (100) 181 (6) 67 hr740 (12)780 (4)Phosphorus-32 e 2 p) Neutron activation ~- (100) None 14.26 daysSamarium-153 C S3 Sm) Neutron activation ~- (100) 103 (29) 1.93 daysStrontium-89 ( 89 Sr) Neutron activation ~- (100) None 50.53 daysTechnetium-99m (99m-Tc) Generator product IT (100) 140 (88) 6.02 hrXenon-133 ( 133 Xe) Nuclear fission ( 235 U) ~- (100) 81 (37) 5.3 daysThallium-201 e0 1 TI) Cyclotron produced EC (100) 69-80 (94) 73.1 hr167(10)Parent material <strong>for</strong> MolTc generator. Not used directlyas a radiopharmaceutical; 740- and 780-keV photonsused to identify "moly breakthrough."Prepared as either sodium or chromic phosphate.<strong>The</strong>rapy: used <strong>for</strong> pain relief from metastatic bonelesions. Advantage compared to 89Sr is that the 153Smdistribution can be imaged.<strong>The</strong>rapy: used <strong>for</strong> pain relief from metastatic bonelesions.This radionuclide accounts <strong>for</strong> more than 70% of allimaging studies.133Xe is a heavier-than-air gas. Low abundance and lowenergy of photon reduces image resolution.<strong>The</strong> majority of clinically useful photons are low-energyx-rays (69-80 keV) from mercury 201 e0 1 Hg), thedaughter of 201TI.Although these photons are inPositron-emitting radionuclidesCarbon-11 (l1C) Cyclotron produced ~+ (100) 511 (AR) 20.4 minFluorine-18 C 8 F) Cyclotron produced W (97) 511 (AR) 110 minEC (3)Nitrogen-13 ( 13 N) Cyclotron produced W (100) 511 (AR) 10 minGallium-68 ( G8 Ga) Cyclotron produced ~+ (89) 511 (AR) 68 minEC (11)Rubidium-82 ( 82 Rb) Generator product ~+ (100) 511 (AR) 75 secThis radionuclide accounts <strong>for</strong> more than 80% of allclinical positron emission tomography studies;typically <strong>for</strong>mulated as fluorodeoxyglucose (FOG).Note: W, Beta-minus decay; W, beta-plus (positron) decay; AR, annihilation radiation; EC, electroncapture; IT, isomeric transition (i.e., gamma ray emission).

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