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Bush__The_Essential_Physics_for_Medical_Imaging - Biomedical ...

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412 Section II: Diagnostic RadiologyMacromoleculeProtons bound tomacromoleculeHydrationLayer. .Bulk WaterI IH.,H:~,H H.,H:010 --I: I )H.JiOHI H./{ I H.,H1 0 0H.,HIH.,H1 0 1 0IH.,HI-(,H I0H.,H~,HO H.nH.,H00A: 01,H • I H.,H)H3~,H I 01 11. ,H0 H.I,HH.,HO~,H~H.,H H.,HIH.,H° I 00 010H.,H1: H.,H O. : H.,H» H.,HI 0 H.,H I ~,H 00IH.,HO I01 0 II IRF Excitation(off-resonance pulse)~FIGURE 14-34. Magnetization transfer contrast is implemented with an offresonanceradiofrequency pulse of about 1,500 Hz from the Larmor frequency.Excitation and dephasing of hydrogen atoms on the surface of macromoleculesis transferred via the hydration layer to adjacent "free water"hydrogen atoms. A partial saturation of the tissues reduces the signals thatwould otherwise compete with signals from blood flow.Axel L, et al. Glossary of MR terms, 3rd ed. Reston, VA: American College of Radiology, 1995.Brown MA, Smelka RC. MR: basic principles and applications. New Yotk: John Wiley & Sons,1995.Hendrick RE. <strong>The</strong> AAPM/RSNA physics tutorial <strong>for</strong> residents. Basic physics of MR imaging: anintroduction. Radiographies 1994; 14:829-846.NessAiver M. All you really need to know about MRl physics. Baltimore: Simply <strong>Physics</strong>, 1997.Plewes DB. <strong>The</strong> AAPM/RSNA physics tutorial <strong>for</strong> residents. Contrast mechanisms in spin-echoMR imaging. Radiographies 1994; 14: 1389-1404.

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