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Bush__The_Essential_Physics_for_Medical_Imaging - Biomedical ...

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Should be administered within 10 min to4 hr after preparation.Administer within 30 min after preparation.Single photon emission computedtomography (SPECT)images only.As with "'In W8Cs, careful isolation andlabeling of wacs is essential to maintaincell viability.Mix reagent thoroughly be<strong>for</strong>ewithdrawing dose; avoid drawing bloodinto syringe or injecting through IVtubing to prevent nonuni<strong>for</strong>mdistribution of particles. Inject patientssupine.Normal increase in activity in distal aspectof long bones compared with diaphyses.Higher target to background thanpyrophosphate; 85% urinary excretionwith MDP vs. 65% with pyrophosphate in24 hr.~ gTABLE 0-1 (continued).Method ofRadiopharmaceutical administrationDelay be<strong>for</strong>eimagingMethod oflocalizationClinicalutility99mTcDMSA IV(dimercaptosuccinicacid), also known asSuccimer (DI)After IV administration 99mTcSuccimer is bound to plasmaproteins. Cleared fromplasma with a half-life ofabout 60 min andconcentrates in the renalcortex.Evaluation of renal parenchymaldisorders.99mTcExametazime, also IVknown as Ceretec andHMPAO (DI)Rapidly cleared from blood.Lipophilic complex, brainuptake -4% of injecteddose occurs -1 min afterinjection.Detection of altered regionalcerebral perfusion in stroke,Alzheimer's disease, seizures,etc.methylene blue stabilization,Ceretec can be used toradiolable leukocytes as anadjunct in the localization ofWhen <strong>for</strong>mulated withoutintra-abdominal infection andinflammatory bowel disease.99mTcMacro aggregated IValbumin (MAA) (DI)-85% 99mTcMAA mechanicallytrapped in arterioles andcapillaries. Particle size(-15-80 ~m). Distribution inlungs is a function ofregional pulmonary bloodflow.Scintigraphic evaluation of pulmonaryperfusion; -0.6 million(range 0.2-1.2 million) particlesare injected with an adult dose.Not to be used <strong>for</strong> patients withsevere pulmonary hypertensionor history of hypersensitivity tohuman serum albumin.99mTcMedronate, also IVknown as 99mTcmethyenediphosphonate(MDP)(DI)Specific affinity <strong>for</strong> areas ofaltered osteogenesis. Uptakerelated to osteogenicactivity and skeletalperfusion. -50% bone,-50% bladder in 24 hr.Skeletal imaging agent. Threephase (flow, blood pool, boneuptake); used to distinguishbetween cellulitis andosteomyelitis. <strong>The</strong>ory of boneuptake: (a) hydroxyapatitecrystal binding; (b) collagendependent uptake in organicbone matrix.

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