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Bush__The_Essential_Physics_for_Medical_Imaging - Biomedical ...

Bush__The_Essential_Physics_for_Medical_Imaging - Biomedical ...

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TABLE 25-5. SUMMARY OF THE STAGES, DOSE RANGE, MAJOR CLINICAL SYMPTOMS, AND EFFECT OF MEDICALINTERVENTION ON THE ACUTE RADIATION SYNDROMEPossible if stem cell supportor replacement is successfulDeath likely, but survival possibleif stem cell support orreplacement is successfulDeath within 5-12 daysProdromal Manifest-illnessSyndrome Dose range effects effectsHematological 0.5-1.0 Gy Mild Slight decrease in blood(50-100 rad) cell count1.0-2.0 Gy Mild to moderate Early symptoms of(100-200 rad) bone-marrow damage2.0-3.5 Gy Moderate Moderate to severe(200-350 rad) bone-marrow damageSurvival withouttreatmentSurvival withtreatment3.5-5.5 Gya Moderate to severe Severe bone-marrow(350-550 rad) damage; slightintestinal damage5.5-8.0 Gy Severe Bone-marrow(550-800 rad) pancytopenia andmoderate intestinaldamageDeath likely within3-6 wkDeath likely within2-3 wk8.0-10.0 Gy Severe Combined gastrointestinal(800-1000 rad) and bone-marrowdamage; hypotensionGastrointestinal 10.0-50.0 Gy(1,000-5,000 rad)Severe prodromal symptoms, hematologicalsyndrome which overlaps with severegastrointestinal damage; electrolyte imbalance;fatigue, gastrointestinal deathSevere prodromal symptoms which overlap withcentral nervous system effects, Ataxia, severeedema, neurovascular damage, shock

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