FoodEurope Issue 4 2016

ingredients 29
About DuPont Nutrition &
Health
DuPont Nutrition & Health
combines in-depth knowledge
of food and nutrition with
current research and expert
science to deliver unmatched
value to the food, beverage
and dietary supplement
industries. We are innovative
solvers, drawing on deep
consumer insights and a broad
product portfolio to help our
customers turn challenges into
high-value business
opportunities. More
information is available at
www.food.dupont.com.
placebo-controlled, multicentre
six-month trial demonstrated the
probiotic and synbiotic (fiber plus
probiotic combination) seem to
control body fat mass, especially in
the abdominal area in overweight
adults. The probiotic and synbiotic
treatment groups both
demonstrated reduced energy
intake during the trial and reduced
waist circumference.
“The potential influence of the gut
microbiota on the regulation of
body weight and shape is an
exciting area right now,” said
Megan DeStefano, Probiotics
global marketing lead at DuPont
Nutrition & Health. “Around the
world, consumers are seeking
natural support for weight
management. In DuPont
proprietary market research, we
have identified that 57% of the
global population are confused
about what they should eat and
what will help them achieve weight
goals without making major
lifestyle changes. 1 We believe this
product will give our customers a
great market opportunity.” Of
particular interest, the
improvements in waist
measurements observed in this
study equate to a reduction in one
waist size of pants.
Only the consumption
of the combination of
Bifidobacterium lactis
420 with Litesse ®
Ultra polydextrose
led to improvements in
lean body mass
Methodology
The volunteers in the study were
randomised into one of four groups
and asked to consume the study
product daily for six months.
Subjects consumed either placebo,
microcrystalline cellulose, 12g/d,
the prebiotic fiber Litesse ® Ultra
polydextrose, 12g/d, DuPont
proprietary strain of probiotic
Bifidobacterium lactis 420, 1010
CFU/d in microcrystalline
cellulose, 12g/d, or the
combination of the prebiotic fiber
and the probiotic strain. This study
assessed changes in fat and lean
tissue using a precise tool, dualenergy
X-ray absorptiometry, for
analysis of body composition to
detect changes in different regions
of the body. Both the probiotic and
synbiotic products helped control
body fat mass, leading to an
approximately 1.4kg difference
compared to placebo in those
participants who adhered to the
study protocol. Only the
consumption of the combination of
Bifidobacterium lactis 420 with
Litesse ® Ultra polydextrose led
to improvements in lean body
mass.
“This is the first study to translate
findings from studies of the
probiotic strain Bifidobacterium
lactis 420 done in animal models,
in which it was shown the probiotic
can improve metabolic health in
mice by strengthening gut barrier
function,” said Lotta Stenman,
Ph.D., lead investigator on the
preclinical and clinical trials, with
DuPont Nutrition & Health. “There
is a long history of research on this
particular probiotic strain, starting
from initial findings from cell
culture studies published in 2008.
It is exciting to see the extensive
preclinical and mechanistic work
paved the way for identifying a
benefit to human health.”
The study was conducted following
Good Clinical Practice guidelines
at four research clinics in Finland.
DuPont Nutrition & Health will
continue to conduct research on
the role of probiotic and prebiotic
supplementation on gut microbiota
and outcomes related to obesity
and metabolic syndrome –
conditions that currently affect
over a third of the global
population.
What we do
DuPont has been bringing world-class science and
engineering to the global marketplace in the form of
innovative products, materials, and services since
1802. The company believes that by collaborating with
customers, governments, NGOs and thought leaders
we can help find solutions to such global challenges as
providing enough healthy food for people everywhere,
decreasing dependence on fossil fuels, and protecting
life and the environment.
www.foodmagazine.eu.com issue four | 2016