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Body mass index (BMI) is a measure

of weight (in kg or lb) relative to

height (in m or in) that roughly

approximates body fat. The

formulae are

BMI = kg ÷ m²

BMI = lb × 703 ÷ in²

The World Health Organization

classifies BMI into four categories.

BMI

Classification

<18.5 underweight

18.5–24.99 normal weight

≥25

≥30

overweight

obese

NONMEDICAL DIETARY

SYSTEMS

Some dietary systems are adopted more often for

ethical or aesthetic reasons than for medical ones.

Low-fat and low-carbohydrate diets are among the

most popular of myriad approaches for losing

weight. Vegetarian and organic foods are increasingly

popular as well, both separately and in

combination.

Like medical dietary systems, nonmedical

dietary systems are promoted by marketers and

advocates. Adherents to these diets often believe

fervently in the health and lifestyle benefits of

their choices, despite a lack of reliable scientific

evidence to back those beliefs.

The largest controlled clinical trial of weight

loss plans conducted to date, for example, concluded

that any dietary system will help you lose

weightas long as it provides fewer calories than

your usual fare. The trick to weight loss, however,

isn’t in shedding the pounds but in keeping them

off. This same study found that participants began

to gain weight back after just one year.

But science offers some good news as well:

carrying a modest amount of extra weight may not

be as bad for you as we’ve been counseled to

believe. A 12-year prospective study of more than

11,000 adults found that those who are technically

classified as overweight according to their body

mass index were slightly less likely to die of any

cause than their peers of so-called “normal”

weight. Underweight people were 73% more likely

to die than those of normal weight. A bit of

padding may give people, especially the elderly,

the reserves they need to cope with the metabolic

demands of fighting disease.

Weight Loss Diets

The promise of weight loss drives a major industry

that takes in billions of dollars in revenue each

year in the United States alone. Over the years, in

a pattern that is similar to the rise and promotion

of medical dietary systems, scores of weight loss

plans have been published and marketed.

No one has taken credit for authoring the

archetypal plan: the grapefruit diet, which has

been in circulation since the 1930s. It was touted

as a quick, short-term way to lose weight. Although

the premise is that drinking grapefruit

juice or eating the fruit combined with protein

promotes weight loss, the dietwhich restricts

carbohydrates to vegetables and grapefruitaverages

so few calories per day that most people will

inevitably lose weight in the short term.

One small study has shown that the addition

of grapefruit to one’s diet might be more than

old-time lore: 91 obese patients with metabolic

syndrome were randomized to take either

placebo or grapefruit in various formscapsule,

juice, or freshfor 12 weeks. Everyone who

consumed grapefruit lost weight and had improved

insulin responses after eating (meaning

their bodies more appropriately drew glucose

from their blood into their cells), but those who

ate half a fresh grapefruit before each meal lost

the most weight (1.6 kg / 3.6 lb over three

months) and had the best postmeal insulin

profile. The authors note that half a fresh grapefruit

has fewer calories than the quantity of

grapefruit juice that the subjects drank and more

fiber, which promotes a feeling of fullness. The

acidity of grapefruit may also keep food in the

stomach longer, delaying the return of hunger.

The Shangri-La diet, developed by a psychologist,

supposes that foods that are familiar and rich

will prompt the brain to crave more of them,

leading to weight gain. Foods that are unfamiliar

and bland will trick the brain into thinking food is

scarce, thus lowering the body’s “set point,” or

weight that it naturally maintains.

The trick (according to the story) is to consume

a few tablespoons of fructose water or

extra-light olive oil between meals. The diet’s

author alleges that this step, which provides

calories but little taste, retrains the mind so that

it no longer associates calories with taste and

thus craves food less often. So far, however, the

only evidence supporting the idea comes from

experiments with rats.

Weight Watchers

A much more robust set of studies has looked at

Weight Watchers, one of the most enduring diet

programs. Initially just an informal support

group, Weight Watchers has developed into

a multifaceted, multitrack weight loss plan. Many

nutrition experts approve of Weight Watchers

because it stresses that weight loss and maintenance

require long-term lifestyle changes,

including more physical activity, and it teaches

the skills and provides ongoing support for those

changesaddressing the psychosocial as well as

the physiologic facets of weight loss.

Unlike many other weight loss systems, Weight

Watchers does not eliminate or overly restrict any

food or food group, so adherents claim to feel less

deprived. Users can count calories with the help of

several tools that assign proxy values (Weight

Watchers’ trademarked Points system), including

an online portal, or they can use a new program

that permits unlimited consumption of “filling

foods” from all the food groups.

A 2008 study tracked down a random sample

of successful Weight Watchers participants who

had met their weight loss goals and achieved

lifetime membership status. Upon weighing

these participants, the investigators found that

half had maintained at least 5% of their weight

loss after five years, and one-sixth (16.2%)

remained below their goal weight at the five-year

mark. The authors of the study note that these

results far exceed those found in most randomized,

controlled trials of lifestyle changes for

obesity treatment. But that may be due largely to

the fact that study subjects were recruited from

only the most successful subgroup of Weight

Watchers members.

Rich with vegetables, beans, nuts, olive oil, and

whole grains, the Mediterranean diet has been

linked in observational studies with a high

quality of life and low rates of chronic disease.

A recent meta-analysis of observational studies of

the Mediterranean diet concludes that those who

adhere to it enjoy significant reductions in overall

mortality, death from heart disease, incidence of

and death from cancer, and incidence of Parkinson’s

and Alzheimer’s disease.

The diet is less clearly responsible for weight

loss: a review of studies revealed just one that

associated the Mediterranean diet (35% fat,

calorie-restricted) with weight loss, compared

with a low-fat (20%), calorie-restricted diet with

the same calories (1,200–1,500 per day). After 18

months, the Mediterranean diet group had lost

an average of 4.8 kg / 10.5 lb, while those in the

low-fat group had begun to gain back their initial

impressive weight loss (an average of 5.1 kg /

11.2 lb) to average a 2.9 kg / 6.4 lb loss.

Investigators in the Nurses’ Health Study

II, a long-term prospective study, assessed

the weight loss success of young and

middle-aged women. More than half of the

women who lost more than 10% of their

body weight gained it all back.

NURSES’ HEALTH STUDY II

Studied outcome: long-term weight loss

Study duration: six years

Participants: 47,515

Results: 2,590 lost >5% of body weight

5.5% lost more than 5% of body weight

Of those 2,590 women, 1,204 (46.5%) regained,

within 5 years, all weight lost

Results: 1,326 (2.8%) lost >10% of body weight

Of those 1,326 women, 751 (56.6%) regained,

within five years, all weight lost

The Nurses’ Health Study II also suggested

the more weight women lost, the more

they regained compared with their peers.

Weight-stable women were more likely to

use exercise for weight control than

nonweight-stable women; cyclers were

more likely to diet than noncyclers.

NURSES’ HEALTH STUDY II

Studied outcome: long-term weight change

after multiple cycles of weight loss and regain

Study Duration: eight years

Participants: 544 women who remained

weight-stable from 1989–1993

741 mild cyclers who lost ≥4.5 kg / 10 lb three

times from 1989–1993

224 severe cyclers who lost ≥9 kg / 20 lb three

times from 1989–1993

Results: women who were weight-stable from

1989 to 1993 had gained the least weight by

2001; women who were severe cyclers gained

the most weight

Weight gain, 1993–2001:

46.5% regained it

2.8% lost more than 10% of body weight

2.7 kg / 5.9 lb

Weight-stable women

Mild weight-cyclers

6.9 kg / 15.2 lb

Severe weight-cyclers

8.5 kg / 18.8 lb

56.6% regained it

240 VOLUME 1 · HISTORY AND FUNDAMENTALS

FOOD AND HEALTH 241

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