Food & Ingredients International April 2024

Tate & Lyle Partners with Cryptobiotix:
New ex-vivo study on low and
no calorie sweeteners finds
positive impact or no impact
on human gut microbiota
Tate & Lyle and
Cryptobiotix’s breakthrough
ex-vivo* study shows that
sucralose does not impact
the gut microbiota, while
other low and no calorie
sweeteners have potentially
beneficial health effects.
journal the International Journal of Food
Sciences and Nutrition, found that some of the
studied low calorie and no calorie sweeteners
had no impact on the gut microbiota, while
others had potential beneficial health effects.
Using Cryptobiotix’s cutting-edge SIFR ®
(“cipher”) technology to recreate the gut
A new, first-of-its-kind study has identified
unique and potentially beneficial interactions
between certain low and no calorie
sweeteners, including stevia, and the human
gut microbiota. Tate & Lyle PLC (Tate &
Lyle), a world leader in ingredient solutions
for healthier food and drink, partnered
with Cryptobiotix, pioneers in preclinical
gastrointestinal research, on the study.
Dr. Davide Risso, molecular biology specialist
and Tate & Lyle’s Head of Nutrition Research,
led the project to explore the potential impact
of certain low and no calorie sweeteners
on the gut environment in both healthy
individuals and those with type 2 diabetes.
The research involved taking samples from
co-living adults consuming a similar diet – to
lower the potential variation introduced by
differences in long-term diet, a major driver of
microbiota composition. The doses of low and
no calorie sweeteners used were based on
actual intakes, regulations and amounts that
are generally included in foods and beverages
during different timepoints.
Results from the pre-clinical study, published
in the leading peer reviewed, open-access
18 FOOD & INGREDIENTS INTERNATIONAL APRIL 2024