Seafood ChoiCeS

Seafood Choices: Balancing Benefits and Risks
http://www.nap.edu/catalog/11762.html
APPENDIX B
Amount Results Conclusion**
Fish oil = 1.08 g/day EPA +
0.72 g/day DHA
Mustard oil = 2.9 g/day
ALA
Placebo = 100 mg/day
aluminum hydroxide
Fat advice = reduce fat to
30% of total energy and
increase polyunsaturated
to saturated ratio to 1.0
Fish advice = consume at
least 2 weekly portions
of 200-400 g fatty fish
(or 0.15 g of MaxEPA
capsules daily if one
could not tolerate fish)
Fiber advice = increase
intake of cereal fiber to
18 g daily
Compared to the placebo group, those in the
fish oil group had significantly lower relative
risks of angina pectoris (RR=0.42, 95%
CI 0.22-0.77), total arrhythmias (RR=0.46,
95% CI 0.21-0.98), total cases with poor left
ventricular function (RR=0.48, 95% CI 0.28-
0.82), NYHA class III and IV heart failure
(RR=0.44, 95% CI 0.18-0.88), and total
cardiac events (RR=0.70, 95% CI 0.29-0.90).
Compared to the placebo group, the fish
oil group also had lower relative risks of
ventricular ectopic beats (>8/minute and >3
consecutively), left ventricular enlargement,
hypotension, sudden cardiac death, total cardiac
death, and nonfatal reinfarction, but these
were not significant.
Serious concerns have been raised about the
performance and conclusions of this trial and
other related publications by this investigator.
Total mortality and IHD mortality was significantly
lower in the fish advice group than in
the non-fish advice group (p