Black Cohosh - Non-Timber Forest Products
Black Cohosh - Non-Timber Forest Products
Black Cohosh - Non-Timber Forest Products
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Keywords: Clinical studies, physiological actions.<br />
Eagon, P.K.; Tress, N.B.; Ayer, H.A. [and others]. 1999. Medicinal<br />
botanicals with hormonal activity [Abstract #1073]. Proceedings of the<br />
American Association for Cancer Research. 40: 161-162.<br />
Investigates the hormonal activity of several herbs used to treat menopausal<br />
symptoms, using in vitro estrogen or progesterone receptor binding assays<br />
and in vivo observations of ovariectomized rats. <strong>Black</strong> cohosh showed a<br />
dose-dependent inhibition of estradiol binding at estrogen receptor sites in<br />
vitro, and both uterine weight increases and hypothalamic/pituitary response<br />
in female rats. These results indicated an estrogen-like activity for black<br />
cohosh.<br />
Keywords: Clinical studies, physiological actions.<br />
Eckman, C.B.; Yager, D.; Haugabook, S.; Abdul, F., inventors; Mayo<br />
Foundation for Medical Education and Research, assignee. 2003.<br />
Methods of reducing .beta.-amyloid polypeptides. U.S. patent 6,649,196.<br />
November 18. 1 p. Int. CI 2 A61K 035/78. http://patft.uspto.gov/<br />
netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=/netahtml/<br />
search-bool.html&r=1&f=G&l=50&co1=AND&d=ptxt&s1=6,649,<br />
196.WKU.&OS=PN/6,649,196&RS=PN/6,649,196. [Date accessed:<br />
September 13, 2004].<br />
Patents the use of black cohosh to reduce levels of .beta.-amyloid<br />
polypeptides. The accumulation of these peptides in the hippocampus and<br />
neocortex is believed to contribute to the onset of Alzheimer’s disease.<br />
Keywords: Medicinal uses, patents.<br />
Einbond, L.S.; Shimizu, M.; Xiao, D. [and others]. 2004. Growth inhibitory<br />
activity of extracts and purified components of black cohosh on human<br />
breast cancer cells. Breast Cancer Research and Treatment. 83: 221-231.<br />
Examines various extracts and chemical constituents of black cohosh to<br />
determine their effects on human breast cancer cells. In vitro assays were<br />
performed with three extracted fractions: hexane, ethyl acetate, and water.<br />
The ethyl acetate fraction inhibited growth of estrogen positive MCF7<br />
and estrogen negative MDA–MB–453 human breast cancer cell lines at<br />
the highest potency of the three extracts. Three specific constituents—the<br />
triterpene glycosides actein, 23–epi-26–deoxyactein, and cimiracemoside<br />
37
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