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Black Cohosh - Non-Timber Forest Products

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Keywords: Clinical studies, physiological actions.<br />

Wuttke, W.; Seidlová-Wuttke, D.; Gorkow, C. 2003. The Cimicifuga<br />

preparation BNO 1055 vs. conjugated estrogens in a double-blind<br />

placebo-controlled study: effects on menopause symptoms and bone<br />

markers. Maturitas. 44(Suppl. 1): S67-S77.<br />

Compares the selective estrogen receptor modulator (SERM) effects of<br />

the black cohosh extract BNO 1055 (Klimadynon ® /Menofem ® ) to those of<br />

conjugated estrogens or a placebo in a randomized, double-blind clinical<br />

trial with postmenopausal women. <strong>Black</strong> cohosh showed similar results<br />

to estrogen in reducing hot flashes and bone loss and increasing vaginal<br />

superficial cells. <strong>Black</strong> cohosh did not show any effect on endometrial<br />

thickness. These results suggested that black cohosh had constituents with<br />

SERM activity that affected the brain/hypothalamus, bones, and vagina, but<br />

did not affect the uterus.<br />

Keywords: Clinical studies, Klimadynon ® /Menofem ® , medicinal uses,<br />

physiological actions.<br />

Xu, H.; Fabricant, D.S.; Johnson, H.E. [and others]. 2001. Using random<br />

amplified polymorphic DNA (RAPD) markers to identify plant species<br />

and variants. [Abstract]. In: Botanical dietary supplements: natural<br />

products at a crossroads; 2001 Nov 8-11; Asilomar, CA. Washington,<br />

DC: American Society of Pharmacognosy and Council for Responsible<br />

Nutrition: p. 32.<br />

Reports on the use of random amplified polymorphic DNA markers to<br />

identify plant species, confirming the use of the technique to discern black<br />

cohosh from other medicinal plant species.<br />

Keywords: Chemical constituents, research.<br />

Zerega, N.J.C.; Mori, S.; Lindqvist, C. [and others]. 2002. Using<br />

amplified fragment length polymorphisms (AFLP) to identify black<br />

cohosh (Actaea racemosa). Economic Botany. 56(2): 154-164.<br />

Reports on the use of DNA fingerprinting to analyze and identify rhizomes<br />

of black cohosh and related species (Actaea pachypoda, A. cordifolia, and<br />

A. podocarpa). Two black cohosh products were evaluated by amplified<br />

fragment length polymorphisms (AFLP) analysis and found to contain<br />

only black cohosh. AFLP was found to be a successful method to evaluate<br />

product quality. Wild populations of black cohosh in Virginia and North<br />

Carolina were also evaluated, but did not contain sufficient genetic markers<br />

76

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