Black Cohosh - Non-Timber Forest Products

climacteric complaints. Wien Med Wochenschr. 152(15-16): 360-363. In
German.
Presents the results of clinical studies on the medicinal properties of black
cohosh.
Keywords: Clinical studies, medicinal uses.
Winterhoff, H.; Spengler, B.; Christoffel, V. [and others]. 2003.
Cimicifuga extract BNO 1055: reduction of hot flushes and hints of
antidepressant activity. Maturitas. 44(Suppl. 1): S51-S58.
Shows a significant reduction in hot flushes and antidepressant activity in
rats administered the ethanolic black cohosh extract BNO 1055 contained in
Klimadynon ® /Menofem ® .
Keywords: Clinical studies, Klimadynon ® /Menofem ® , medicinal uses.
Woo, K.C.; Park, Y.S.; Jun, D.J. [and others]. 2004. Phytoestrogen
cimicifugoside-mediated inhibition of catecholamine secretion by
blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin
cell. Journal of Pharmacology and Experimental Therapeutics. 309: 641-
649.
Investigates the effects of cimicifugoside, a pharmacologically active
compound found in the roots of black cohosh.
Keywords: Clinical studies, physiological actions, phytoestrogens.
Wuttke, W.; Jarry, H.; Heiden, I. [and others]. 2000. Selective estrogen
receptor modulator (SERM) activity of the Cimicifuga racemosa
extract BNO 1055: pharmacology and mechanisms of action [Abstract].
Phytomedicine. 7(Suppl. 2): 12.
Tests the estrogenic effects of the black cohosh extract BNO 1055.
Ovariectomized rats were treated with either estradiol or black cohosh for
6 hours, 7 days, or 3 months. Estradiol stimulated the uterus, yet black
cohosh did not. Both estradiol and black cohosh prevented the development
of osteoporosis. Black cohosh also showed beneficial effects on hepatic and
lipid metabolism and on the central nervous system, which may account for
its ability to reduce hot flashes. The authors concluded that black cohosh
contains phyto-selective estrogen receptor modulators that have no effect on
the uterus but showed desirable effects on other organs.
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