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Black Cohosh - Non-Timber Forest Products

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provide forest managers with information about the regeneration of black<br />

cohosh to ensure that harvest levels remain within sustainable limits.<br />

Keywords: Conservation, harvest, monitoring.<br />

Seibel, M.M. 2003. Treating hot flushes without hormone replacement<br />

therapy. Journal of Family Practice. 52(4): 291-296.<br />

Summarizes information on herbs used as alternatives to hormone<br />

replacement therapy, including soy (Glycine max), dong quai (Angelica<br />

sinensis), black cohosh, evening primrose (Oenothera biennis), and red<br />

clover (Trifolium pratense).<br />

Keywords: Hormone replacement therapy, medicinal uses.<br />

Seidlová-Wuttke, D.; Hesse, O.; Jarry, H. [and others]. 2003. Evidence<br />

for selective estrogen receptor modulator activity in a black cohosh<br />

(Cimicifuga racemosa) extract: comparison with estradiol-17beta.<br />

European Journal of Endocrinology. 149: 351-362.<br />

Compares the selective estrogen receptor modulator (SERM) activity of the<br />

black cohosh extract BNO 1055 (Klimadynon ® /Menofem ® ) to estrogen.<br />

After a 3-month treatment with black cohosh or estrogens, ovariectomized<br />

rats showed both decreased luteinizing hormone secretion and reduced<br />

bone loss. The estrogen group also showed uterine weight gain and<br />

progesterone receptor activity, whereas the group using black cohosh did<br />

not. Results indicated that black cohosh has SERM properties that act in the<br />

hypothalamus/pituitary system and prevent bone loss without stimulating<br />

the uterus. The active constituents remained unidentified.<br />

Keywords: Chemical constituents, clinical studies, medicinal uses,<br />

physiological actions.<br />

Seidlová-Wuttke, D.; Jarry, H.; Heiden, I.; Wuttke, W. 2000. Effects<br />

of Cimicifuga racemosa on estrogen dependent tissues [Abstract].<br />

Phytomedicine. 7(Suppl. 2): 11.<br />

Evaluates the activity of black cohosh in the uterus, bone, liver, and aorta.<br />

Subacute and chronic treatments with black cohosh extract BNO 1055 were<br />

compared to treatments with estradiol in rats. <strong>Black</strong> cohosh showed no<br />

effect on uterine weight, but acted similarly to estrogen in the bone, liver,<br />

and aorta. These results suggested that black cohosh has phytoselective<br />

estrogen receptor (ER) modulator activity acting mainly upon ER-β.<br />

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