Black Cohosh - Non-Timber Forest Products
Black Cohosh - Non-Timber Forest Products
Black Cohosh - Non-Timber Forest Products
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that black cohosh was not more effective than a placebo; however, the<br />
authors stated that most women use black cohosh in doses higher than those<br />
used in this study.<br />
Keywords: Cancer, dosage, hot flashes, luteinizing hormone, safety.<br />
Jarry, H.; Harnischfeger, G. 1985. Studies on the endocrine efficacy<br />
of the constituents of Cimicifuga racemosa: 1. Influence on the serum<br />
concentration of pituitary hormones in ovariectomized rats. Planta<br />
Medica. 51(1): 46-49.<br />
Reports on the measurement of levels of serum concentrations of pituitary<br />
hormones in ovariectomized rats. After 3 days, there was a significant<br />
reduction in luteinizing hormone (LH) levels, but the follicle-stimulating<br />
hormone and prolactin levels were unaffected. Spikes in LH release have<br />
been linked to occurrences of hot flashes, and so served as a measure of<br />
endocrinological activity. The agents responsible for this selective reaction<br />
were believed to be a glycoside fraction and a lipophilic fraction (triterpene<br />
glycosides). This study provides evidence of an endocrine-like efficacy for<br />
black cohosh root.<br />
Keywords: Chemical constituents, clinical studies, hot flashes, luteinizing<br />
hormone.<br />
Jarry, H.; Harnischfeger, G.; Düker, E. 1985. Studies on the endocrine<br />
efficacy of the constituents of Cimicifuga racemosa: 2. In vitro binding of<br />
constituents to estrogen receptors. Planta Medica. 51(4): 316-319.<br />
Investigates the mechanism of action by which black cohosh reduces<br />
symptoms of menopause. Results showed an estrogenic effect on the<br />
hypothalamus/pituitary glands, which control the release of the luteinizing<br />
hormone associated with hot flashes. The black cohosh extract did not bind<br />
to estrogen receptors (α or β), but did show estrogenic action in human<br />
endometrium cytosol. The authors speculated that black cohosh possibly<br />
binds to an unidentified estrogen receptor, and/or has dopaminergic active<br />
compounds.<br />
Keywords: Chemical constituents, clinical studies, luteinizing hormone,<br />
physiological actions.<br />
Jarry, H.; Metten, M.; Spengler, B. [and others]. 2003. In vitro effects<br />
of the Cimicifuga racemosa extract BNO 1055. Maturitas. 44(Suppl. 1):<br />
S31-S38.<br />
45
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