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D10: Impact of Contaminants - Hydromod

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Integrated Water Resource Management for Important Deep European Lakes and their Catchment Areas<br />

EUROLAKES<br />

<strong>D10</strong>: <strong>Impact</strong> <strong>of</strong> <strong>Contaminants</strong><br />

ANNEX 1<br />

Schemata with the mode <strong>of</strong> action <strong>of</strong> endocrine disrupters<br />

FP5_Contract No.: EVK1-CT1999-00004<br />

Version: 4.0<br />

Date: 25/07/01<br />

File: <strong>D10</strong>-vers.4.0.doc<br />

Page 131 <strong>of</strong> 136<br />

Cells have receptors where hormones are able to tie<br />

down. The hormone-receptor-complex is activating the<br />

cell. Natural hormones dock at receptors and activates<br />

it in the appropriate level [WWF CANADA, DEVITT<br />

1997].<br />

Endocrine disrupters are able to dock at the receptor,<br />

too. They are blocking normal signals because the<br />

body hormones can not fit into the receptor. Hormone<br />

blockers interferes with the signal from the body hormones<br />

[WWF CANADA, DEVITT 1997].<br />

The messages send by the endocrine disrupters are<br />

wrong. Either they give a signal stronger than the<br />

body's hormone (and at the wrong time), or...<br />

endocrine disrupter gives a signal weaker than natural<br />

hormones and at the wrong time [WWF CANADA,<br />

DEVITT 1997].

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