D10: Impact of Contaminants - Hydromod
D10: Impact of Contaminants - Hydromod
D10: Impact of Contaminants - Hydromod
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Integrated Water Resource Management for Important Deep European Lakes and their Catchment Areas<br />
EUROLAKES<br />
<strong>D10</strong>: <strong>Impact</strong> <strong>of</strong> <strong>Contaminants</strong><br />
ANNEX 1<br />
Schemata with the mode <strong>of</strong> action <strong>of</strong> endocrine disrupters<br />
FP5_Contract No.: EVK1-CT1999-00004<br />
Version: 4.0<br />
Date: 25/07/01<br />
File: <strong>D10</strong>-vers.4.0.doc<br />
Page 131 <strong>of</strong> 136<br />
Cells have receptors where hormones are able to tie<br />
down. The hormone-receptor-complex is activating the<br />
cell. Natural hormones dock at receptors and activates<br />
it in the appropriate level [WWF CANADA, DEVITT<br />
1997].<br />
Endocrine disrupters are able to dock at the receptor,<br />
too. They are blocking normal signals because the<br />
body hormones can not fit into the receptor. Hormone<br />
blockers interferes with the signal from the body hormones<br />
[WWF CANADA, DEVITT 1997].<br />
The messages send by the endocrine disrupters are<br />
wrong. Either they give a signal stronger than the<br />
body's hormone (and at the wrong time), or...<br />
endocrine disrupter gives a signal weaker than natural<br />
hormones and at the wrong time [WWF CANADA,<br />
DEVITT 1997].