D10: Impact of Contaminants - Hydromod

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Integrated Water Resource Management for Important Deep European Lakes and their Catchment Areas EUROLAKES D10: Impact of Contaminants FP5_Contract No.: EVK1-CT1999-00004 Version: 4.0 Date: 25/07/01 File: D10-vers.4.0.doc Page 24 of 136 the organisms or not at all of a population's vitality. The same test results had been obtained for tests which check the receptor binding of environmental chemicals and those which should determine the estrogene potential. New test methods has been developed in the recent years which are based on the sensitivity of human tumour cells for estrogens.
Integrated Water Resource Management for Important Deep European Lakes and their Catchment Areas EUROLAKES D10: Impact of Contaminants FP5_Contract No.: EVK1-CT1999-00004 Version: 4.0 Date: 25/07/01 File: D10-vers.4.0.doc Page 25 of 136 6 METHODS OF DETERMINING THE ENDOCRINE EFFECT OF SUBSTANCES 6.1 BACKGROUND For regulatory purposes toxicological tests have to be carried out according to internationally accepted test guidelines. However, in several recent workshops and publications it has been discussed whether the current test guidelines are suitable for identifying endocrine disrupters: • SETAC-Europe/OECD/EC Expert Workshop on Endocrine Modulators and Wildlife: Assessment and Testing (EMWAT), Veldhoven, Netherlands, 10-13 April 1997; • the OECD is at the moment finalising the Detailed Review Paper (DRP): “Appraisal of Test Methods for Sex-Hormone Disrupting Chemicals”. The document has been prepared by the United Kingdom as a proposed basis on which to assess the suitability and availability of existing test methods used both by OECD member states and the research community. This document was circulated to the OECD National Test Guidelines Co-ordinators in April 1997 and has been recently revised to take account of comments received. A final document has yet to be published; • a draft report from February 1998 of the activities of the Endocrine Disrupter Screening Testing and Advisory Committee (EDSTAC) of the US-EPA; • a publication in Environmental Toxicology and Chemistry by [ANKLEY et al. 1998] entitled “Overview of a workshop on screening methods for detecting potential (anti-) oestrogenic/androgenic chemicals in wildlife”. A summary of all tests available at the moment - including the recommendations for their enhancement with respect to endocrine disrupters - discussed in EMWAT, DRP and EDSTAC was presented by the OECD in a background paper of the first meeting of the OECD Endocrine Disrupter Testing and Assessment Working Group (EDTA), March 10-11, 1998. Test guidelines for invertebrates (OECD 202), fish (OECD 203, 204, 210 and 212 and the draft 28-days juvenile growth) and birds (OECD 205 and 206) and several tests with mammals like the OECD 407 and 416 are discussed therein. It is stated that none of the current OECD ecotoxicology test guidelines are specifically designed to detect endocrine disrupters. The same can be argued for the EU test guidelines as only regulatory test guidelines are available for acute tests with fish and daphnia’s, with non-specific endpoints, including growth and mortality. The need for revision of existing OECD test guidelines and the development of new test guidelines specifically to address the potential adverse effects arising as a result of endocrine disruption, has been proposed by several organisations, such as EDSTAC, and in workshops on endocrine disrupters, such as EMWAT. Rather than discussing all ex-
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D10: Impact of Contaminants - Hydromod

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