D10: Impact of Contaminants - Hydromod

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Integrated Water Resource Management for Important Deep European Lakes and their Catchment Areas EUROLAKES D10: Impact of Contaminants FP5_Contract No.: EVK1-CT1999-00004 Version: 4.0 Date: 25/07/01 File: D10-vers.4.0.doc Page 42 of 136 tions be straightened to that aim and the results of the studies (e. g. NOEC, LOEC, effect thresholds) be part of the risk assessment in accordance to their importance. The used models like the PEC/PNEC model described above are for the evaluation of single substances. The effects caused by different substances are unconsidered. Therefore it is necessary to develop new models where combination effects of different hormonal active substances could be integrated in the risk assessment [BÄTSCHER et al 1999].
Integrated Water Resource Management for Important Deep European Lakes and their Catchment Areas EUROLAKES D10: Impact of Contaminants FP5_Contract No.: EVK1-CT1999-00004 Version: 4.0 Date: 25/07/01 File: D10-vers.4.0.doc Page 43 of 136 7 IMPACTS OF HORMONAL ACTIVE CHEMICALS TO HUMANS AND ANIMALS Substances where an endocrine effect to several organisms is evidenced or supposed mainly are pesticides and so-called industrial chemicals [LEISEWITZ 1996]. They are part of the in 0 pictured group of POPs. A list of environmental chemicals with an endocrine effect is shown in appendix 1. Chloroganical materials have a great importance but not all in this context suspected environmental chemicals are chlorinated (phthalates, surfactants, heavy metals etc.) [LEISEWITZ 1996]. 7.1 THE HAZARDOUSNESS OF ENVIRONMENTAL CHEMICALS The effects of xenobiotics are intensively cross-linked at the different biologicalecological levels, shown in the Figure 7-1. immediatlysome days hoursweeks weeksmonths monthsyears monthsdecades timetable attitude change Neurological and endocrinesymptomsbalance/orientation,locomotion, motivation/ability to learn contaminant biological-molecular reaction Enzym and metabolism activity induktion of xenometabolism-enzyms changes of membranes, DNA-mutation physiological changes morphological changes Oxigen depletion, ions-regulation, photosynthesis integration of food, digestion, excretion changes in the individual life cycle Embryonic development growth rate, reproduction, regenerative capacity changes in the population Reducted number of individuals, change in the age distribution, generally modified of ressources gene pool ecological consequences Changes in the biocoenosis/ecosystem with regard to dynamics, structure and function Histological and cytological changes Figure 7-1: Cross-linked effects to different biological-ecological levels, according to [FENT 1998]
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D10: Impact of Contaminants - Hydromod

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