Cancer Research in Switzerland - Krebsliga Schweiz

More documents

Recommendations

Info

108 Radtke Freddy | The role of Notch and TSLPR signaling during skin cancer (KLS 02387022009) Duration: 01.08.2009 – 01.08.2012 Our studies previously showed that loss of Notch signalling in the skin results in a severe form of inflammation characterized as atopic dermatitislike disease (AD, also known as eczema) due to excessive production of thymic stromal lymphopoietin (TSLP) by Notch deficient keratinocytes. TSLP is a secreted cytokine that is deeply implicated in the pathogenesis of AD and asthma in mouse and human. We genetically removed the TSLPR to prove that TSLP signalling is indeed causative of the development of AD in mice having lost Notch1 and Notch2 in the skin. These mice were rescued from developing AD; however, unexpectedly they developed rapidly growing invasive skin tumours, suggesting that TSLP induces a type of inflammation that protects premalignant lesions from progressing into tumours. We are currently trying to identify the cellular and molecular mechanisms of the TSLPmediated protective inflammation. This should lead to novel insights into how the immune system tries to fight against cancer. Project coordinator Prof. Dr Freddy Radtke UPRAD Institut suisse de recherche expérimentale sur le cancer (ISREC) Faculté des sciences de la vie EPF de Lausanne (EPFL) Station 19 CH1015 Lausanne Phone +41 (0)21 693 07 71 freddy.radtke@epfl.ch Renner Christoph | Inhibition of tumor growth by targeting cancer-associated fibroblasts (KFS 02500082009) Duration: 01.01.2010 – 01.01.2013 Tumours are composed of tumour cells and a variable degree of stroma, which includes extracellular matrix and fibroblasts. These tumour fibroblasts support tumour growth and are characterized by the expression of fibroblast activation protein (FAP). FAP is a dipeptidyl peptidase known to cleave extracellular matrix (such as collagen), which in turn leads to enhanced metastasis formation. We postulate that FAPblocking molecules can inhibit this process and stop tumour metastasis. Therefore, we developed mousehuman crossreactive FAPspecific antibodies that downregulate FAP expression, and we will analyze them in mouse models for their potential to impact on metastasis formation using new imaging approaches. It is our final goal to transfer this approach into a clinical setting for the benefit of patients with advanced malignant diseases. Project coordinator Prof. Dr. Christoph Renner Klinik und Poliklinik für Onkologie Medizinbereich Innere Medizin – Onkologie UniversitätsSpital Zürich Rämistrasse 100 CH8091 Zürich Phone +41 (0)44 255 21 54 christoph.renner@usz.ch Ruiz i Altaba Ariel | Role and prevalence of hedgehog signalling in human colorectal cancer (KFS 02359022009) Duration: 01.07.2010 – 01.07.2013 Despite huge efforts to improve treatments, metastatic cancers are still linked to a high rate of mortality. This is the case for colon cancer, which accounts for about 10 % of all cancer deaths worldwide, with 25 % of the cases being out of any surgical therapy because of metastasis. The transition step from primary tumour to metastatic state therefore appears to be critical in the development of the disease and should be considered as a priority target for future therapies. In this imperative perspective, we propose to study, in a collaborative effort involving surgeons of the University hospital Geneva (HUG), the molecular mechanisms underlying this metastatic transition step. Our data suggest that the development of colorectal cancer requires the activity of the sonic hedgehog (SHH)Gli pathway, a cell signalling pathway that we have previously identified as being deregulated in other cancers, namely, brain, skin and prostate cancers. From these data, (SHH)Gli pathway should play an essential role in the tight regulation of colon cancer stem cells from which the tumour arises, as well as in later phases of the disease, like the metastatic transition. To validate these working hypotheses, we propose to compare the tumourigenic properties of colon carcinoma cells obtained from patient biopsies at different stages of the disease by using mice xenograft models. These experiments are expected to bring new insights into the molecular mechanisms underlying the biology of intestinal tumourigenesis and should allow for the identification and development of specific (SHH)Gli pathway antagonists to treat colorectal tumours and their cancer stem cells more efficiently. Project coordinator Prof. Dr Ariel Ruiz i Altaba Département de génétique médicale et de développement Faculté de médecine Université de Genève 1, rue MichelServet CH1211 Genève 4 Phone +41 (0)22 379 54 46 Fax +41 (0)22 379 59 62 ariel.ruizaltaba@unige.ch
Santamaria Anna | Control of chromosome segregation fidelity by the Ska complex, a key regulator of stable kinetochore-microtubule attachments during mitosis (KFS 02657082010) Duration: 01.02.2011– 01.02.2014 During development of every organism, each dividing cell must partition its replicated genome equally into each new daughter cell. Errors in this process lead to aneuploid daughter cells with abnormal numbers of chromosomes. Aneuploidy is a remarkably common characteristic of aggressive tumours. Compelling evidence suggests that excessively stable kinetochoremicrotubule (KTMT) attachments are the root cause of chromosomal instability (CIN) in many cancer cells. Central to the machinery required for establishing stable KTMT attachments is the Ska (for spindle and kinetochoreassociated) complex. Our goal is to elucidate the role of the Ska complex in generating stable KTMT attachments during mitosis in human cells by: 1) identifying its interaction partners and studying the regulation of the Ska complex by phosphorylation using biochemical and cell biological techniques; 2) resolve the structure of the Ska complex by Xray crystallography; 3) analyze the abundance, stochiometry and dynamics of endogenous Ska proteins in both normal and tumour cells using mass spectrometrybased techniques. These studies should allow us to determine whether protein imbalances in key regulators of KTMT attachments are a likely root cause of CIN in cancer cells. This will provide an opportunity to explore KTrelated pathways and strategies that elevate chromosome missegregation beyond tolerable levels for therapeutic applications. Project coordinator Dr. Anna Santamaria Departement Biozentrum Universität Basel Klingelbergstrasse 50/70 CH4056 Basel Phone +41 (0)61 267 18 93 Fax +41 (0)61 267 20 09 anna.santamaria@unibas.ch
Page 1 and 2:
Cancer Research in Switzerland A pu
Page 3 and 4:
Cancer Research in Switzerland
Page 5 and 6:
Basic biomedical research 55 Cancer
Page 7 and 8:
policy work and was in charge of de
Page 9 and 10:
The main focus of the research fund
Page 11 and 12:
gramme research funding decreased b
Page 13 and 14:
Table 2 Distribution of funds for i
Page 15 and 16:
Funding patient-centred research Pa
Page 17 and 18:
value was not clearly discernible.
Page 19 and 20:
New organization of the Foundation
Page 21 and 22:
The board of the Foundation Cancer
Page 23 and 24:
The president of the Scientific Com
Page 25 and 26:
Prof. Martin Pruschy, PhD Departmen
Page 27 and 28:
Swartz wants to find out how tumour
Page 29 and 30:
The scientific and medical research
Page 31 and 32:
3. The original order/sequence of t
Page 33 and 34:
As a federation, the Cancer League
Page 35 and 36:
List of funded research projects, i
Page 37 and 38:
Zippelius Alfred | 2009: CHF 100,00
Page 39 and 40:
Kridel Robert | 2010: CHF 100,000.-
Page 41 and 42:
Thurgau Cancer League Biotechnologi
Page 43 and 44:
Weller Michael | 2010: CHF 65,828.-
Page 45 and 46:
manageable funding of individual pr
Page 47 and 48:
enhances breast cancer cell motilit
Page 49 and 50:
Rüegg Curzio et al. | Tumor-mediat
Page 51 and 52:
International Clinical Cancer Resea
Page 53 and 54:
in PHIV were shown for Hodgkin’s
Page 55:
Zucca Emanuele et al. | Internation
Page 58 and 59:
56 “hierarchical structure” of
Page 60 and 61: 58 the attempt should be made to st
Page 62 and 63: 60 Gönczy Pierre | KLS 0202402
Page 64 and 65: 62 Romero Pedro | OCS 020110220
Page 66 and 67: 64 Beermann Friedrich | In vivo scr
Page 68 and 69: 66 Christofori Gerhard | Podoplanin
Page 70 and 71: 68 Frei Christian | The function of
Page 72 and 73: 70 cell, this novel mechanism serve
Page 74 and 75: 72 Results The induction of viral p
Page 76 and 77: 74 Hübscher Ulrich | Repair of oxi
Page 78 and 79: 76 Methods and experimental approac
Page 80 and 81: 78 of cMyc and/or NMyc and demo
Page 82 and 83: 80 In summary, this work improves o
Page 84 and 85: 82 Pruschy Martin | Microtubule int
Page 86 and 87: 84 Renner Christoph | Selective inh
Page 88 and 89: 86 Goal Here we build on these obse
Page 90 and 91: 88 by TDG prevents efficient downst
Page 92 and 93: 90 To address these questions, we a
Page 94 and 95: 92 Translational relevance The resu
Page 96 and 97: 94 Grünberg Jürgen | KFS 025460
Page 98 and 99: 96 Tschan Mario P. | KFS 0248608
Page 100 and 101: 98 Boyman Onur | Preclinical testin
Page 102 and 103: 100 Constam Daniel | Role of activi
Page 104 and 105: 102 this study we will examine the
Page 106 and 107: 104 Janscak Pavel | Study of the ro
Page 108 and 109: 106 Müller Anne | The molecular pa
Page 112 and 113: 110 Schär Primo | DNA repair, epig
Page 114 and 115: 112 In this project we will investi
Page 116 and 117: 114
Page 118 and 119: 116 and Research). Other financial
Page 120 and 121: 118 be totally unaffordable for aca
Page 122 and 123: 120 Clinical research List of compl
Page 124 and 125: 122 Hunger Robert E. | OCS 02262-08
Page 126 and 127: 124 Clinical research Presentation
Page 128 and 129: 126 Benhattar Jean | Identification
Page 130 and 131: 128 Bertoni Francesco | Genome-wide
Page 132 and 133: 130 Interpretation ESA treatment in
Page 134 and 135: 132 Our results could pave the way
Page 136 and 137: 134 new drugs that specifically tar
Page 138 and 139: 136 slides in two different concent
Page 140 and 141: 138 Conclusions A strong network of
Page 142 and 143: 140 tions introduced to ARE motifs
Page 144 and 145: 142 Müller Beatrice U. | The maste
Page 146 and 147: 144 A novel method was developed fo
Page 148 and 149: 146 (SAKK 35-98) the Swiss Group fo
Page 150 and 151: 148 Timmermann Beate | Prospective
Page 152 and 153: 150 recurrence of the disease, we a
Page 154 and 155: 152 Zucca Emanuele | A prospective
Page 156 and 157: 154 Heinimann Karl | KFS 02489-08-2
Page 158 and 159: 156 Riggi Nicolò | BIL KFS 02717-0
Page 160 and 161:
158 activity at the single cell lev
Page 162 and 163:
160 Our research projects aim at un
Page 164 and 165:
162 Körner Meike | In vitro evalua
Page 166 and 167:
164 Nadal David | Is endemic Burkit
Page 168 and 169:
166 (> 50.000/patient). For their a
Page 170 and 171:
168 Zeller Rolf | Functional analys
Page 172 and 173:
170
Page 174 and 175:
172 area of health services researc
Page 176 and 177:
174 The financing of palliative car
Page 178 and 179:
176 National Strategy for Palliativ
Page 180 and 181:
178 Psychosocial research List of c
Page 182 and 183:
180 Within the patient group, level
Page 184 and 185:
182 Further, the results suggest th
Page 186 and 187:
184 It is in this context that the
Page 188 and 189:
186 Recommendation Female spouses o
Page 190 and 191:
188 Psychosocial research Presentat
Page 192 and 193:
190 rates communication skills rema
Page 195 and 196:
Epidemiological research Epidemiolo
Page 197 and 198:
data from cancer registries. In the
Page 199 and 200:
The importance of cancer registries
Page 201 and 202:
Ess Silvia | Patterns of care and s
Page 203 and 204:
Epidemiological research List of ap
Page 205 and 206:
Impact This work will serve as the
Page 207 and 208:
Thürlimann Beat | Management of br
show all

Cancer Research in Switzerland - Krebsliga Schweiz

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?