Cancer Research in Switzerland - Krebsliga Schweiz

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92 Translational relevance The results suggest that immunotherapy for glioma may be partially successful with peripheral approaches such as vaccination, but locally applied treatments or reducing immunosuppressive factors may be necessary for full efficacy. Project coordinator PD Dr Paul R. Walker Laboratoire d’immunologie des tumeurs Centre d’oncologie Hôpitaux universitaires de Genève (HUG) 4, rue GabriellePerretGentil CH1211 Genève 14 Phone +41 (0)22 372 98 80 paul.walker@hcuge.ch Wymann Matthias P. | Phosphoinositide 3-kinases in melanoma (OCS 01924082006) Advanced metastatic melanoma is refractory to conventional chemotherapy. Phosphoinositide 3kinases (PI3Ks) are lipid kinases – enzymes phosphorylating lipids at the plasma membrane – and act as a key relay of growth, proliferation and cell migration. Initial studies using potent, broadband PI3K inhibitors have demonstrated the sensitivity of melanoma to PI3K inhibition. Work with genetically targeted mice shows that broadband PI3K inhibitors affect metabolic control, the immune system and cardiovascular parameters. To minimize side effects, the role of specific PI3K isoforms on tumour autonomous control in melanoma will be investigated. In this context, a murine B16 cell tumour transfer model will be used. Altogether, the proposed work will define the prospect and the profile of future therapies targeting PI3Ks in melanoma. Project coordinator Prof. Dr. Matthias P. Wymann Institut für Biochemie und Genetik Departement Biomedizin Universität Basel Mattenstrasse 28 CH4058 Basel Phone +41 (0)61 695 30 46 matthias.wymann@unibas.ch Further completed research projects from July 2008 to December 2010 Pelkmans Lucas | OCS 02111082007 | CHF 198,000.– Institut für molekulare Systembiologie, ETH Zürich, Zürich How focal adhesion kinase (FAK) controls membrane partitioning and endocytosis of cell adhesion components in normal and in cancer cells Stamenkovic Ivan | OCS 01656022005 | CHF 173,900.– Institut universitaire de pathologie de Lausanne (IUP), Centre hospitalier universitaire vaudois (CHUV), Lausanne Analysis of the molecular mechanisms underlying the pathogenesis of EWING’S family tumors
Basic biomedical research List of approved research projects in 2009/2010 Total funds allocated: CHF 11,792,000.– Aguet Michel | KFS 02674082010 | CHF 234,400.– Institut suisse de recherche expérimentale sur le cancer (ISREC), Faculté des sciences de la vie, EPF de Lausanne, Lausanne Role of BCL9/BCL9L in regulating Wnt-mediated epithelial-mesenchymal transition, stem cell traits and drug sensitivity in Wnt-activated human cancers Basler Konrad | KFS 02443082009 | CHF 169,400.– Institut für molekulare Biologie, Universität Zürich, Zürich Characterization of the role of histone binding by the WnT-signalling components Pygo2 in murine models of breast cancer and colon cancer Becher Burkhard | KFS 02441082009 | CHF 203,000.– Institut für experimentelle Immunologie, Departement Pathologie, UniversitätsSpital Zürich, Zürich Cellular and molecular characterization of IL-12-mediated tumor suppression Boyman Onur | KFS 02672082010 | CHF 343,400.– Dermatologische Klinik, UniversitätsSpital Zürich, Zürich Preclinical testing of interleukin-2-antibody complexes for tumor immunotherapy Brisken Cathrin | KFS 02462082009 | CHF 331,200.– NCCR Molecular Oncology, Institut suisse de recherche expérimentale sur le cancer (ISREC), Faculté des sciences de la vie, EPF de Lausanne, Lausanne Mechanisms of action of progesterone in the human breast Brown Steven A. | KFS 02642082010 | CHF 240,100.– Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Universität Zürich, Zürich The mechanism of cancer and circadian clock interactions and its usefulness in the design of therapeutic strategies Christofori Gerhard | KLS 02535022010 | CHF 283,200.– Institut für Biochemie und Genetik, Departement Biomedizin, Universität Basel, Basel The functional role of the transcription factors DIx2 and Lhx2 in epithelial-mesenchymal transition (EMT) and in malignant tumor progression Constam Daniel | KFS 02487082009 | CHF 307,600.– UPCDA, Institut suisse de recherche expérimentale sur le cancer (ISREC), Faculté des sciences de la vie, EPF de Lausanne, Lausanne Role of activin signalling in metastatic melanoma Dotto Gian-Paolo | OCS 02361022009 | CHF 314,350.– Département de biochimie, Faculté de biologie et de médecine, Université de Lausanne, Epalinges Tumor suppressing function of calcineurin/NFAT in keratinocytes Dufour Jean-François | KFS 02541022010 | CHF 202,200.– Institut für klinische Pharmakologie, Universität Bern, Bern Hepatocarcinogenic roles of mTOR, raptor and rapamycins in absence of Pten Gönczy Pierre | KLS 02584022010 | CHF 197,000.– UPGON, Institut suisse de recherche expérimentale sur le cancer (ISREC), Faculté des sciences de la vie, EPF de Lausanne, Lausanne Mechanisms of centrosome duplication: From model organism towards therapeutic opportunities Grassi Fabio | KFS 02445082009 | CHF 144,000.– Istituto di ricerca biomedicina (IRB), Bellinzona Purinergic signalling in the pathophysiology of central nervous system infiltration in T-cell leukemia 93
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Cancer Research in Switzerland A pu
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Cancer Research in Switzerland
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Basic biomedical research 55 Cancer
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policy work and was in charge of de
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The main focus of the research fund
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gramme research funding decreased b
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Table 2 Distribution of funds for i
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Funding patient-centred research Pa
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value was not clearly discernible.
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New organization of the Foundation
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The board of the Foundation Cancer
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The president of the Scientific Com
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Prof. Martin Pruschy, PhD Departmen
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Swartz wants to find out how tumour
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The scientific and medical research
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3. The original order/sequence of t
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As a federation, the Cancer League
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List of funded research projects, i
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Zippelius Alfred | 2009: CHF 100,00
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Kridel Robert | 2010: CHF 100,000.-
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Thurgau Cancer League Biotechnologi
Page 43 and 44: Weller Michael | 2010: CHF 65,828.-
Page 45 and 46: manageable funding of individual pr
Page 47 and 48: enhances breast cancer cell motilit
Page 49 and 50: Rüegg Curzio et al. | Tumor-mediat
Page 51 and 52: International Clinical Cancer Resea
Page 53 and 54: in PHIV were shown for Hodgkin’s
Page 55: Zucca Emanuele et al. | Internation
Page 58 and 59: 56 “hierarchical structure” of
Page 60 and 61: 58 the attempt should be made to st
Page 62 and 63: 60 Gönczy Pierre | KLS 0202402
Page 64 and 65: 62 Romero Pedro | OCS 020110220
Page 66 and 67: 64 Beermann Friedrich | In vivo scr
Page 68 and 69: 66 Christofori Gerhard | Podoplanin
Page 70 and 71: 68 Frei Christian | The function of
Page 72 and 73: 70 cell, this novel mechanism serve
Page 74 and 75: 72 Results The induction of viral p
Page 76 and 77: 74 Hübscher Ulrich | Repair of oxi
Page 78 and 79: 76 Methods and experimental approac
Page 80 and 81: 78 of cMyc and/or NMyc and demo
Page 82 and 83: 80 In summary, this work improves o
Page 84 and 85: 82 Pruschy Martin | Microtubule int
Page 86 and 87: 84 Renner Christoph | Selective inh
Page 88 and 89: 86 Goal Here we build on these obse
Page 90 and 91: 88 by TDG prevents efficient downst
Page 92 and 93: 90 To address these questions, we a
Page 96 and 97: 94 Grünberg Jürgen | KFS 025460
Page 98 and 99: 96 Tschan Mario P. | KFS 0248608
Page 100 and 101: 98 Boyman Onur | Preclinical testin
Page 102 and 103: 100 Constam Daniel | Role of activi
Page 104 and 105: 102 this study we will examine the
Page 106 and 107: 104 Janscak Pavel | Study of the ro
Page 108 and 109: 106 Müller Anne | The molecular pa
Page 110 and 111: 108 Radtke Freddy | The role of Not
Page 112 and 113: 110 Schär Primo | DNA repair, epig
Page 114 and 115: 112 In this project we will investi
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Page 118 and 119: 116 and Research). Other financial
Page 120 and 121: 118 be totally unaffordable for aca
Page 122 and 123: 120 Clinical research List of compl
Page 124 and 125: 122 Hunger Robert E. | OCS 02262-08
Page 126 and 127: 124 Clinical research Presentation
Page 128 and 129: 126 Benhattar Jean | Identification
Page 130 and 131: 128 Bertoni Francesco | Genome-wide
Page 132 and 133: 130 Interpretation ESA treatment in
Page 134 and 135: 132 Our results could pave the way
Page 136 and 137: 134 new drugs that specifically tar
Page 138 and 139: 136 slides in two different concent
Page 140 and 141: 138 Conclusions A strong network of
Page 142 and 143: 140 tions introduced to ARE motifs
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142 Müller Beatrice U. | The maste
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144 A novel method was developed fo
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146 (SAKK 35-98) the Swiss Group fo
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148 Timmermann Beate | Prospective
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150 recurrence of the disease, we a
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152 Zucca Emanuele | A prospective
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154 Heinimann Karl | KFS 02489-08-2
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156 Riggi Nicolò | BIL KFS 02717-0
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158 activity at the single cell lev
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160 Our research projects aim at un
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162 Körner Meike | In vitro evalua
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164 Nadal David | Is endemic Burkit
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166 (> 50.000/patient). For their a
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168 Zeller Rolf | Functional analys
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170
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172 area of health services researc
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174 The financing of palliative car
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176 National Strategy for Palliativ
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178 Psychosocial research List of c
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180 Within the patient group, level
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182 Further, the results suggest th
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184 It is in this context that the
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186 Recommendation Female spouses o
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188 Psychosocial research Presentat
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190 rates communication skills rema
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Epidemiological research Epidemiolo
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data from cancer registries. In the
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The importance of cancer registries
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Ess Silvia | Patterns of care and s
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Epidemiological research List of ap
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Impact This work will serve as the
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Thürlimann Beat | Management of br
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