Cancer Research in Switzerland - Krebsliga Schweiz

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120 Clinical research List of completed research projects from July 2008 to December 2010 Aebersold Daniel M. | OCS 01681-02-2005 | CHF 172,800.– Klinik und Poliklinik für Radio-Onkologie, Inselspital, Bern The role of activating point mutations in the met receptor tyrosine kinase in tumor radioresistance Baege Astrid | KLS 02220-02-2008 | CHF 220,100.– Klinik für Gynäkologie, UniversitätsSpital Zürich, Zürich The role of adult stem cells in HPV-associated carcinogenesis: Identification of the HPV target cell capable of driving viral persistence Ballmer Peter E. | OCS 02000-02-2007 | CHF 155,800.– Klinik für Innere Medizin, Departement für Medizin, Kantonsspital Winterthur, Winterthur Influence of a nutritional intervention on clinical course and quality of life in cancer patients Benhattar Jean | OCS 01638-02-2005 | CHF 203,000.– Institut universitaire de pathologie de Lausanne (IUP), Centre hospitalier universitaire vaudois (CHUV), Lausanne Identification of biomarkers for early cancer detection in Barrett’s esophagus patients using methylation profiles and the Wnt pathway Bertoni Francesco | KLS 01835-02-2006 | CHF 177,900.– Gruppo genomica funzionale e linfomi, Laboratorio di oncologia sperimentale, Istituto oncologico della Svizzera italiana (IOSI), Bellinzona Evaluation of the tyrosine kinase SYK as a possible therapeutic target in lymphomas Bertoni Francesco | OCS 01939-08-2006 | CHF 226,800.– Gruppo genomica funzionale e linfomi, Laboratorio di oncologia sperimentale, Istituto oncologico della Svizzera italiana (IOSI), Bellinzona Genome-wide DNA profiling as outcome predictor in diffuse large B-cell lymphoma Bertoni Francesco | OCS 02034-02-2007 | CHF 157,800.– Gruppo genomica funzionale e linfomi, Laboratorio di oncologia sperimentale, Istituto oncologico della Svizzera italiana (IOSI), Bellinzona Extranodal, nodal and splenic marginal zone B-cell lymphomas: How much are they related to each other? Bohlius Julia | OCS 02146-10-2007 | CHF 128,100.– Forschungsgruppe Krebs, Institut für Sozial- und Präventivmedizin (ISPM), Universität Bern, Bern Individual patient data meta-analysis on the effects of erythropoiesis-stimulating agents in cancer patients Bourquin Jean-Pierre | KLS 02124-08-2007 | CHF 226,600.– Abteilung Onkologie, Kinderspital Zürich, Universitäts-Kinderkliniken, Zürich A leukemia xenotransplantation model to evaluate combinatorial approaches for the treatment of de novo drug resistant childhood acute lymphoblastic leukemia Continuation in the project: Bourquin Jean-Pierre | KFS 02453-08-2009 | CHF 125,500.– Abteilung Onkologie, Kinderspital Zürich, Universitäts-Kinderkliniken, Zürich Pre-clinical evaluation of a new pharmacological approach using obatoclax for chemosensitization of drug resistant childhood acute lymphoblastic leukemia Duration: 01.03.2010 – 01.03.2011 Carbone Giuseppina | OCS 01913-08-2006 | CHF 183,800.– Laboratorio di oncologia sperimentale, Istituto oncologico della Svizzera italiana (IOSI), Bellinzona Functional and clinical implications of deregulated expression of ETS transcription factors in prostate cancer Cozzi Luca | OCS 01821-02-2006 | CHF 80,800.– Servizio di fisica medica, Istituto oncologico della Svizzera italiana (IOSI), Ospedale regionale di Bellinzona e valli, Bellinzona Heterogeneity management in advanced algorithms for photon dose calculation and the clinical impact on breast and lung cancer radiotherapy. Validation of existing models against experimental studies, Monte Carlo simulations and determination of potential
De Libero Gennaro | KLS 02211-02-2008 | CHF 159,500.– Experimentelle Immunologie, Departement Biomedizin, Universität Basel, Basel Lipid-specific T-cells against leukaemic blasts Dirnhofer Stephan | OCS 01792-10-2005 | CHF 297,800.– Institut für Pathologie, Universitätsspital Basel, Basel Inducing cell death in apoptosis-resistant hematological tumors: Impact on diagnosis and therapeutic intervention Doucey Marie-Agnès | OCS 02069-04-2007 | CHF 214,800.– Centre pluridisciplinaire d’oncologie (CePO), Centre hospitalier universitaire vaudois (CHUV), Lausanne Functional and biochemical characterization of human monocyte-like circulating cells in breast cancer patients: Relevance to tumor growth and angiogenesis Dubey Raghvendra K. | OCS 01551-08-2004 | CHF 258,300.– Klinik für Reproduktions-Endokrinologie, UniversitätsSpital Zürich, Zürich Pathophysiological role of estrogen metabolism in breast cancer Frattini Milo | OCS 01921-08-2006 | CHF 102,300.– Laboratorio di diagnostica molecolare, Istituto cantonale di patologia (ICP), Locarno Characterization of EGFR deregulation and EGFR downstream cascade in colorectal cancer patients, and relationship to new targeted therapies Garayoa Elisa Garcia | KLS 02040-02-2007 | CHF 150,700.– Zentrum für radiopharmazeutische Wissenschaften, Paul Scherrer Institut (PSI), Villigen Development of new bombesin-based radiopharmaceuticals with improved pharmacokinetics as potential imaging and therapeutic agents for bombesin receptor-positive tumours Gautschi Oliver | KLS 02164-02-2008 | CHF 218,200.– Departement für klinische Forschung, Universität Bern, Inselspital, Bern Regulation of lD1 expression by Src in cancer: Clinical implications Heim Markus Hermann | OCS 02192-02-2008 | CHF 245,200.– Klinik für Gastroenterologie und Hepatologie, Universitätsspital Basel, Basel Hepatocarcinogenesis in chronic hepatitis C Continuation of the project: Heim Markus Hermann | KLS 01832-02-2006 | CHF 231,700.– Klinik für Gastroenterologie und Hepatologie, Universitätsspital Basel, Basel Hepatocarcinogenesis in chronic hepatitis C Heinzelmann-Schwarz Viola | OCS 02115-08-2007 | CHF 232,100.– Translational Research Group, Klinik für Gynäkologie, Medizinbereich Frau-Kind, UniversitätsSpital Zürich Detection of anti-glycan autoantibodies as biomarkers of high stage serous ovarian cancer; acronym: GOS-study Herrmann Richard | KLS 02067-04-2007 | CHF 490,000.– Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK), Koordinationszentrum, Bern The SAKK initiative for regional hospitals Hess Christoph | OCS 02266-08-2008 | CHF 103,700.– Ambulante Innere Medizin, Medizinische Poliklinik, Universitätsspital Basel, Basel Innate immunity, cytokine polymorphisms, and development of post-transplant lymphoproliferative disease in kidney transplant recipients Hess Viviane | KLS 01881-04-2006 | CHF 87,800.– Medizinische Onkologie, Universitätsspital Basel, Basel Improving treatment for patients with advanced pancreatic cancer (APC): A Swiss-wide effort Hoek Keith | OCS 01927-08-2006 | CHF 145,500.– Dermatologische Klinik, Medizinbereich Trauma-Derma-Rheuma-Plastische Chirurgie, UniversitätsSpital Zürich, Zürich Clinical implications of Wnt signal-driven regulation of melanoma metastatic potential 121
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Cancer Research in Switzerland A pu
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Cancer Research in Switzerland
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Basic biomedical research 55 Cancer
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policy work and was in charge of de
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The main focus of the research fund
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gramme research funding decreased b
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Table 2 Distribution of funds for i
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Funding patient-centred research Pa
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value was not clearly discernible.
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New organization of the Foundation
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The board of the Foundation Cancer
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The president of the Scientific Com
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Prof. Martin Pruschy, PhD Departmen
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Swartz wants to find out how tumour
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The scientific and medical research
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3. The original order/sequence of t
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As a federation, the Cancer League
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List of funded research projects, i
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Zippelius Alfred | 2009: CHF 100,00
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Kridel Robert | 2010: CHF 100,000.-
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Thurgau Cancer League Biotechnologi
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Weller Michael | 2010: CHF 65,828.-
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manageable funding of individual pr
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enhances breast cancer cell motilit
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Rüegg Curzio et al. | Tumor-mediat
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International Clinical Cancer Resea
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in PHIV were shown for Hodgkin’s
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Zucca Emanuele et al. | Internation
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56 “hierarchical structure” of
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58 the attempt should be made to st
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60 Gönczy Pierre | KLS 0202402
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62 Romero Pedro | OCS 020110220
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64 Beermann Friedrich | In vivo scr
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66 Christofori Gerhard | Podoplanin
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68 Frei Christian | The function of
Page 72 and 73: 70 cell, this novel mechanism serve
Page 74 and 75: 72 Results The induction of viral p
Page 76 and 77: 74 Hübscher Ulrich | Repair of oxi
Page 78 and 79: 76 Methods and experimental approac
Page 80 and 81: 78 of cMyc and/or NMyc and demo
Page 82 and 83: 80 In summary, this work improves o
Page 84 and 85: 82 Pruschy Martin | Microtubule int
Page 86 and 87: 84 Renner Christoph | Selective inh
Page 88 and 89: 86 Goal Here we build on these obse
Page 90 and 91: 88 by TDG prevents efficient downst
Page 92 and 93: 90 To address these questions, we a
Page 94 and 95: 92 Translational relevance The resu
Page 96 and 97: 94 Grünberg Jürgen | KFS 025460
Page 98 and 99: 96 Tschan Mario P. | KFS 0248608
Page 100 and 101: 98 Boyman Onur | Preclinical testin
Page 102 and 103: 100 Constam Daniel | Role of activi
Page 104 and 105: 102 this study we will examine the
Page 106 and 107: 104 Janscak Pavel | Study of the ro
Page 108 and 109: 106 Müller Anne | The molecular pa
Page 110 and 111: 108 Radtke Freddy | The role of Not
Page 112 and 113: 110 Schär Primo | DNA repair, epig
Page 114 and 115: 112 In this project we will investi
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Page 118 and 119: 116 and Research). Other financial
Page 120 and 121: 118 be totally unaffordable for aca
Page 124 and 125: 122 Hunger Robert E. | OCS 02262-08
Page 126 and 127: 124 Clinical research Presentation
Page 128 and 129: 126 Benhattar Jean | Identification
Page 130 and 131: 128 Bertoni Francesco | Genome-wide
Page 132 and 133: 130 Interpretation ESA treatment in
Page 134 and 135: 132 Our results could pave the way
Page 136 and 137: 134 new drugs that specifically tar
Page 138 and 139: 136 slides in two different concent
Page 140 and 141: 138 Conclusions A strong network of
Page 142 and 143: 140 tions introduced to ARE motifs
Page 144 and 145: 142 Müller Beatrice U. | The maste
Page 146 and 147: 144 A novel method was developed fo
Page 148 and 149: 146 (SAKK 35-98) the Swiss Group fo
Page 150 and 151: 148 Timmermann Beate | Prospective
Page 152 and 153: 150 recurrence of the disease, we a
Page 154 and 155: 152 Zucca Emanuele | A prospective
Page 156 and 157: 154 Heinimann Karl | KFS 02489-08-2
Page 158 and 159: 156 Riggi Nicolò | BIL KFS 02717-0
Page 160 and 161: 158 activity at the single cell lev
Page 162 and 163: 160 Our research projects aim at un
Page 164 and 165: 162 Körner Meike | In vitro evalua
Page 166 and 167: 164 Nadal David | Is endemic Burkit
Page 168 and 169: 166 (> 50.000/patient). For their a
Page 170 and 171: 168 Zeller Rolf | Functional analys
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170
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172 area of health services researc
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174 The financing of palliative car
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176 National Strategy for Palliativ
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178 Psychosocial research List of c
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180 Within the patient group, level
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182 Further, the results suggest th
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184 It is in this context that the
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186 Recommendation Female spouses o
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188 Psychosocial research Presentat
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190 rates communication skills rema
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Epidemiological research Epidemiolo
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data from cancer registries. In the
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The importance of cancer registries
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Ess Silvia | Patterns of care and s
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Epidemiological research List of ap
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Impact This work will serve as the
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Thürlimann Beat | Management of br
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