Cancer Research in Switzerland - Krebsliga Schweiz

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178 Psychosocial research List of completed research projects from July 2008 to December 2010 Ansermet François | KLS 01705-04-2005 | CHF 273,000.– Service de psychiatrie de l’enfant et de l’adolescent (SPEA), Hôpitaux universitaires de Genève (HUG), Genève Biobehavioral responses to stress in adult survivors of a childhood cancer Eychmüller Steffen | OCS 01776-08-2005 | CHF 170,000.– Palliativzentrum, Kantonsspital St. Gallen, St. Gallen Palliative care services in Switzerland: From a national survey to the development of a specific monitoring instrument Kiss Alexander | KLS 02038-02-2007 | CHF 302,000.– Abteilung Psychosomatik, Departement Innere Medizin, Universitätsspital Basel, Basel Physical and psychological predictors of patient fatigue 1 to 10 years after human stem cell transplantation Lehr Hans-Anton | OCS 02209-02-2008 | CHF 240,400.– Institut universitaire de pathologie de Lausanne (IUP), Centre hospitalier universitaire vaudois (CHUV), Lausanne Biomedical research on human tissues: In the twilight zone between autonomy and data protection. What do health professionals, patients and lay persons think about issues of consent and transparency in medical research, teaching, and quality control? Rüesch Peter | KLS 02198-02-2008 | CHF 155,800.– Fachstelle Gesundheitswissenschaften, Departement für Gesundheit, Zürcher Hochschule für Angewandte Wissenschaften (ZHAW), Winterthur Information needs of patients with curable adenocarcinoma of the prostate and professionals’ opinions: An international study (INEPAP) Schulz Peter J. | OCS 02101-08-2007 | CHF 150,400.– Istituto di comunicazione e sanità, Università della Svizzera italiana, Lugano Cancer and health literacy: Establishing a concept of cancer literacy Schwappach David | OCS 02109-08-2007 | CHF 117,200.– Stiftung für Patientensicherheit, Zürich Involving chemotherapy patients in the prevention of medical errors – a feasibility study Stiefel Friedrich | OCS 01847-02-2006 | CHF 184,600.– Service de psychiatrie de liaison (PLI), Centre hospitalier universitaire vaudois (CHUV), Lausanne Evaluation of individual and group psychotherapy for emotionally distressed cancer patients: A randomized controlled trial Stiefel Friedrich | KLS 02035-02-2007 | CHF 126,300.– Service de psychiatrie de liaison (PLI), Centre hospitalier universitaire vaudois (CHUV), Lausanne Effects of communication skills training on oncology clinicians’ communication styles and defense mechanisms von der Weid Nicolas | KLS 02215-02-2008 | CHF 285,900.– Service de pédiatrie, Centre hospitalier universitaire vaudois (CHUV), Lausanne Longterm outcome of childhood cancer: Incidence and spectrum of late effects Znoj Hansjörg | OCS 01741-08-2005 | CHF 104,800.– Abteilung klinische Psychologie und Psychotherapie, Institut für Psychologie, Universität Bern, Bern Posttraumatic personal growth and posttraumatic stress in patients and their partners adapting to cancer
Psychosocial research Presentation of completed research projects from July 2008 to December 2010 Eychmüller Steffen | Palliative care services in Switzerland: From a national survey to the development of a specific monitoring instrument (OCS 01776-08-2005) Purpose In terms of end of life care, Switzerland is known for its legalization of physician-assisted suicide but less for excellence in palliative care. This study provides the results of a national survey on the current situation of palliative care in the country. Method We conducted a national survey on all hospitals, residential aged care facilities and cancer networks and on a sample of community nursing services stratified by canton, addressing the institutions’ directors/head-nurses. Results In total 2,115 surveys were distributed. Response rate was 57 % (n=1195), with an equal distribution from all care settings all over Switzerland. The overall image of palliative care is positive and largely integrated in conceptual frameworks, but there is no common definition of service characteristics (i. e. for specialist palliative care services), and implementation in daily practice varies widely. Geographically, the distribution of specialist palliative care services shows a predominance of the French-speaking part of Switzerland. Use of specific palliative care assessment tools or guidelines is best within hospital settings. Composition and training of specialist palliative care teams in most of the settings may not reach international standards. As part of the project, a minimal data set for patients in specialist palliative care settings was piloted in 2008 and presented during the national consensus conference for palliative care in December 2008. Conclusion Palliative care is poorly developed in Switzerland with regionally few exceptions due to historic factors. A national strategy has been adopted only recently. Recommendations for the future This national survey was used as a major starting point to be built on for the “National Strategy for Palliative Care 2010–2012” as published at the end of 2009. In addition, a first edition of a Swiss Palliative Care Directory was published in 2008, followed by a second version planned for spring 2011. A national dataset for palliative care patients will be established in cooperation with the Federal Statistical Office in 2011. Potential patient benefit This project has had an enormous impact on the planning and implementation of the national palliative care strategy. This strategy is subdivided into five different domains, reaching from public awareness and services structures to finances, education and research. The results of the project will be used for monitoring future service development and regional access to palliative care. Based on international data on improvement of patients’ outcomes through palliative care services whenever cancer or other diseases cannot be cured, we expect to see similar benefit for patients in our country. Project coordinator Dr. Steffen Eychmüller Palliativzentrum Kantonsspital St. Gallen CH-9007 St. Gallen Phone +41 (0)71 494 3551 steffen.eychmueller@kssg.ch Kiss Alexander | Physical and psychological predictors of patient fatigue 1 to 10 years after human stem cell transplantation (KLS-02038-02-2007) Chronic fatigue is a common, debilitating consequence among patients who have undergone haematopoietic stem cell transplantation (HSCT) as therapy for malignant diseases of the blood-forming system. Fatigue is a major source of impairment to quality of life (QoL) among these patients, is difficult to treat and is not well understood in terms of aetiology or course. Aims A study was conducted to identify physiological and psychological predictors of fatigue among 104 HSCT recipients, 1-to-10 years post-transplantation. 45 age-andgender-matched healthy individuals served as controls. Methods Cardiovascular, respiratory and activity parameters were recorded using the LifeShirt system during a 24-h dailylife ambulatory assessment. Participants completed an electronic diary (every 50 minutes) on momentary states of exhaustion, energy, mood and situation. Retrospective self-report questionnaires assessed QoL, fatigue, anxiety, depression and HSCT-related complaints. Physical fitness was evaluated by bicycle ergometry. Among patients, the same procedure was repeated one year later. Results In comparison with healthy controls, HSCT survivors were less physically fit and remained impaired on many dimensions of health-related QoL. They also reported significantly higher levels of fatigue, anxiety and depression on the retrospective questionnaires. Electronic diary data partially confirmed these findings, with patients reporting substantially more exhaustion over the day than controls. On physiological measures, patients manifested significantly lower respiratory sinus arrhythmia and higher heart rate (HR) across levels of activity and times of day, indicating impaired cardiac vagal tone; group differences remained significant after adjusting for fitness. On the other hand, groups did not differ in daytime physical or metabolic activity (as indexed by accelerometry and minute ventilation). 179
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Cancer Research in Switzerland A pu
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Cancer Research in Switzerland
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Basic biomedical research 55 Cancer
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policy work and was in charge of de
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The main focus of the research fund
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gramme research funding decreased b
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Table 2 Distribution of funds for i
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Funding patient-centred research Pa
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value was not clearly discernible.
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New organization of the Foundation
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The board of the Foundation Cancer
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The president of the Scientific Com
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Prof. Martin Pruschy, PhD Departmen
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Swartz wants to find out how tumour
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The scientific and medical research
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3. The original order/sequence of t
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As a federation, the Cancer League
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List of funded research projects, i
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Zippelius Alfred | 2009: CHF 100,00
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Kridel Robert | 2010: CHF 100,000.-
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Thurgau Cancer League Biotechnologi
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Weller Michael | 2010: CHF 65,828.-
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manageable funding of individual pr
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enhances breast cancer cell motilit
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Rüegg Curzio et al. | Tumor-mediat
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International Clinical Cancer Resea
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in PHIV were shown for Hodgkin’s
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Zucca Emanuele et al. | Internation
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56 “hierarchical structure” of
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58 the attempt should be made to st
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60 Gönczy Pierre | KLS 0202402
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62 Romero Pedro | OCS 020110220
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64 Beermann Friedrich | In vivo scr
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66 Christofori Gerhard | Podoplanin
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68 Frei Christian | The function of
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70 cell, this novel mechanism serve
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72 Results The induction of viral p
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74 Hübscher Ulrich | Repair of oxi
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76 Methods and experimental approac
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78 of cMyc and/or NMyc and demo
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80 In summary, this work improves o
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82 Pruschy Martin | Microtubule int
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84 Renner Christoph | Selective inh
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86 Goal Here we build on these obse
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88 by TDG prevents efficient downst
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90 To address these questions, we a
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92 Translational relevance The resu
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94 Grünberg Jürgen | KFS 025460
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96 Tschan Mario P. | KFS 0248608
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98 Boyman Onur | Preclinical testin
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100 Constam Daniel | Role of activi
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102 this study we will examine the
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104 Janscak Pavel | Study of the ro
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106 Müller Anne | The molecular pa
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108 Radtke Freddy | The role of Not
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110 Schär Primo | DNA repair, epig
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112 In this project we will investi
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114
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116 and Research). Other financial
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118 be totally unaffordable for aca
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120 Clinical research List of compl
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122 Hunger Robert E. | OCS 02262-08
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124 Clinical research Presentation
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126 Benhattar Jean | Identification
Page 130 and 131: 128 Bertoni Francesco | Genome-wide
Page 132 and 133: 130 Interpretation ESA treatment in
Page 134 and 135: 132 Our results could pave the way
Page 136 and 137: 134 new drugs that specifically tar
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Page 140 and 141: 138 Conclusions A strong network of
Page 142 and 143: 140 tions introduced to ARE motifs
Page 144 and 145: 142 Müller Beatrice U. | The maste
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Page 150 and 151: 148 Timmermann Beate | Prospective
Page 152 and 153: 150 recurrence of the disease, we a
Page 154 and 155: 152 Zucca Emanuele | A prospective
Page 156 and 157: 154 Heinimann Karl | KFS 02489-08-2
Page 158 and 159: 156 Riggi Nicolò | BIL KFS 02717-0
Page 160 and 161: 158 activity at the single cell lev
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Page 164 and 165: 162 Körner Meike | In vitro evalua
Page 166 and 167: 164 Nadal David | Is endemic Burkit
Page 168 and 169: 166 (> 50.000/patient). For their a
Page 170 and 171: 168 Zeller Rolf | Functional analys
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Page 174 and 175: 172 area of health services researc
Page 176 and 177: 174 The financing of palliative car
Page 178 and 179: 176 National Strategy for Palliativ
Page 182 and 183: 180 Within the patient group, level
Page 184 and 185: 182 Further, the results suggest th
Page 186 and 187: 184 It is in this context that the
Page 188 and 189: 186 Recommendation Female spouses o
Page 190 and 191: 188 Psychosocial research Presentat
Page 192 and 193: 190 rates communication skills rema
Page 195 and 196: Epidemiological research Epidemiolo
Page 197 and 198: data from cancer registries. In the
Page 199 and 200: The importance of cancer registries
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Page 203 and 204: Epidemiological research List of ap
Page 205 and 206: Impact This work will serve as the
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