Cancer Research in Switzerland - Krebsliga Schweiz

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198 Epidemiological research List of completed research projects from July 2008 to December 2010 Bouchardy Christine | KLS 01759-08-2005 | CHF 310 600.– Registre genevois des tumeurs, Institut national pour l’épidémiologie et l’enregistrement du cancer (NICER), Genève Epidemiologic research on the impact of genetic factors in breast cancer occurrence among the female population of Geneva: A study from the first Familial breast cancer registry in Switzerland Ess Silvia | KLS 01766-08-2005 | CHF 259 500.– Krebsregister St. Gallen-Appenzell, Kantonsspital St. Gallen, St. Gallen Patterns of care and survival in breast cancer patients in Switzerland Levi Fabio | OCS 01633-02-2005 | CHF 265 620.– Unité d’épidémiologie du cancer et Registres vaudois et neuchâtelois des tumeurs, Institut universitaire de médecine sociale et préventive, Centre hospitalier universitaire vaudois (CHUV), Lausanne An integrated network of casecontrol studies on cancer: Nutrition, other environmental and genetic factors Zwahlen Marcel | OCS 01869-02-2006 | CHF 171 400.– Institut für Sozial- und Präventivmedizin, Universität Bern, Bern Risk of childhood leukemia varies little by familial socioeconomic status – while survival time after a brain tumor diagnosis varied considerably by familial socioeconomic status Epidemiological research Presentation of completed research projects from July 2008 to December 2010 Bouchardy Christine | Epidemiologic research on the impact of genetic factors in breast cancer occurrence among the female population of Geneva: A study from the first Familial breast cancer registry in Switzerland (KFS 01759-08-2005) Breast cancer is a public health priority in Switzerland. Family history is one of the major risk factors for breast cancer. To perform innovative studies on the effect of hereditary factors on breast cancer occurrence and outcome, we set up the first and unique Familial breast cancer registry in Switzerland, which currently contains validated family histories of cancer for more than 6,000 patients. Objectives of the study The objectives of our study are to compare pathological characteristics of cancers occurring in the same family and to evaluate the concordance of prognosis between firstdegree relatives with breast cancer. Methods We will compare tumour characteristics between women with breast cancer belonging to the same family, and investigate whether the mother or sister’s prognosis influences the patient’s prognosis. Potential patient benefit These studies will allow to a better understanding of the genetic factors influencing disease prognosis and make it possible in the near future to improve surveillance and care of women with high risk breast cancer. Project coordinator Prof. Dr Christine Bouchardy Registre genevois des tumeurs Institut de médecine sociale et préventive Département de médecine et santé communautaire Université de Genève Bd de la Cluse 55 CH-1205 Genève Phone +41 (0)22 379 49 50 christine.bouchardymagnin@unige.ch
Ess Silvia | Patterns of care and survival in breast cancer patients in Switzerland (KLS 01766-08-2005) Background Breast cancer is the most common malignancy and the first cause of premature mortality for women in Switzerland. Two recently published studies described geographical disparities in breast cancer mortality and 5-year relative survival rates after controlling for prognostic factors like tumour size and nodal status, suggesting that other factors than stage at diagnosis might influence outcome. Although in other countries treatment of breast cancer in specialized units has been shown to result in better outcomes, there is still much debate as to whether specialization in breast cancer care is needed in Switzerland and whether differences that matter to the patient exist. Aims and Methods The aims of this study were to analyze whether differences in the implementation of state-of-the-art management exist and to find predictors for adequate and poor management of early breast cancer in Switzerland. We included 4,800 patients newly diagnosed with breast cancer in the years 2003–2005. Patients were selected from seven population-based cancer registries (Basel, Geneva, Grisons-Glaris, St Gallen/Appenzell, Ticino, Valais and Zurich). Based on the requirements of the European Society of Mastology (EUSOMA) Audit system on Quality of Breast Cancer Treatment criteria, a database was designed. Items included detailed information on patient and tumour characteristics, diagnosis circumstances and treatments planned and delivered as part of the first therapeutic concept. A 10-item score of state-of-the-art management was defined based on national and international guideline items. The score included five items for surgical management, one item for histopathology reporting and four items for adjuvant radiotherapy and systemic treatment. Results Two-thirds of patients were treated with a breast conserving surgery. Age, bigger tumours and residence in a rural area increased the probability to have a mastectomy. We observed geographical disparities regarding the utilization of new surgical procedures (sentinel node biopsy, skin sparing mastectomy) and pre-treatment diagnosis. On the other hand, few differences existed regarding adjuvant radiotherapy and systemic therapies. In one-third of the patients, management met guidelines in all items, whereas in about one-fifth, three or more items did not comply. Treatment by a surgeon with a caseload in the upper tercile and team involved in clinical research were independent predictors of a high score, whereas treatment by a surgeon with a caseload in the lower tercile was associated with a low score. Socioeconomic characteristics such as income and education were not independent predictors, but patient’s place of residence and age independently predicted management according to recommendations. Potential patient benefit In the past few years, increasing awareness of variations in the quality of health care across geographic areas as well as providers in other countries has helped to propel a quality improvement movement. In the Swiss health system, characterized by freedom of choice of provider, the importance of an informed choice of referring physicians and patients is paramount. The introduction of accredited breast units in the near future will increase transparency, facilitate this informed choice and contribute towards reducing disparities. Project coordinator Dr. Silvia Ess Krebsregister St. Gallen-Appenzell Kantonsspital St. Gallen Flurhofstrasse 7 CH-9000 St. Gallen Phone +41 (0)71 494 21 17 Fax +41 (0)71 494 61 76 silvia.ess@kssg.ch Levi Fabio | An integrated network of case-control studies on cancer: Nutrition, other environmental and genetic factors (OCS 01633-02-2005) This is an integrated epidemiology research scheme, designed to identify and better quantify environmental and genetic risk factors for several common cancers – including head and neck (HNC), breast and colorectal cancers – and to estimate the relative and attributable risk in the Swiss and other Southern European populations. The program originated in the late 1980s and has contributed to the definition and quantification of environmental (tobacco, alcohol, diet, physical exercise, etc.) and familial factors in cancer risk. This project has been included in international meta analyses and pooled analyses of various neoplasms including head and neck, breast and colon. Epidemiological data are collected through interviews of patients with cancer and controls admitted to the CHUV in Lausanne. At the end of 2010, the overall dataset included about: 950 cases of HNC cancers (of oral cavity and pharynx, oesophagus and larynx), 600 of colorectal cancers, 800 of breast cancers, and over 4,500 controls. Our recent findings indicated that citrus fruit has a protective role against cancers of the digestive and upper respiratory tract. No association was found with breast cancer. We were involved in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, which includes data from 33 HNC studies worldwide, and a total of about 25,000 cases of 33,000 controls. The influence of family history on HNC risk was investigated, showing an increased risk (odds ratio, OR=1.7) in first-degree relatives that was higher when the affected relative was a sibling rather than a parent and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher in those exposed to tobacco. The OR rose to 7.2 among subjects with family history who were alcohol and tobacco users. 199
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Cancer Research in Switzerland A pu
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Cancer Research in Switzerland
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Basic biomedical research 55 Cancer
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policy work and was in charge of de
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The main focus of the research fund
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gramme research funding decreased b
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Table 2 Distribution of funds for i
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Funding patient-centred research Pa
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value was not clearly discernible.
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New organization of the Foundation
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The board of the Foundation Cancer
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The president of the Scientific Com
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Prof. Martin Pruschy, PhD Departmen
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Swartz wants to find out how tumour
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The scientific and medical research
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3. The original order/sequence of t
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As a federation, the Cancer League
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List of funded research projects, i
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Zippelius Alfred | 2009: CHF 100,00
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Kridel Robert | 2010: CHF 100,000.-
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Thurgau Cancer League Biotechnologi
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Weller Michael | 2010: CHF 65,828.-
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manageable funding of individual pr
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enhances breast cancer cell motilit
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Rüegg Curzio et al. | Tumor-mediat
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International Clinical Cancer Resea
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in PHIV were shown for Hodgkin’s
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Zucca Emanuele et al. | Internation
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56 “hierarchical structure” of
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58 the attempt should be made to st
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60 Gönczy Pierre | KLS 0202402
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62 Romero Pedro | OCS 020110220
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64 Beermann Friedrich | In vivo scr
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66 Christofori Gerhard | Podoplanin
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68 Frei Christian | The function of
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70 cell, this novel mechanism serve
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72 Results The induction of viral p
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74 Hübscher Ulrich | Repair of oxi
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76 Methods and experimental approac
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78 of cMyc and/or NMyc and demo
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80 In summary, this work improves o
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82 Pruschy Martin | Microtubule int
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84 Renner Christoph | Selective inh
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86 Goal Here we build on these obse
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88 by TDG prevents efficient downst
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90 To address these questions, we a
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92 Translational relevance The resu
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94 Grünberg Jürgen | KFS 025460
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96 Tschan Mario P. | KFS 0248608
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98 Boyman Onur | Preclinical testin
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100 Constam Daniel | Role of activi
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102 this study we will examine the
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104 Janscak Pavel | Study of the ro
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106 Müller Anne | The molecular pa
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108 Radtke Freddy | The role of Not
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110 Schär Primo | DNA repair, epig
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112 In this project we will investi
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114
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116 and Research). Other financial
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118 be totally unaffordable for aca
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120 Clinical research List of compl
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122 Hunger Robert E. | OCS 02262-08
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124 Clinical research Presentation
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126 Benhattar Jean | Identification
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128 Bertoni Francesco | Genome-wide
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130 Interpretation ESA treatment in
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132 Our results could pave the way
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134 new drugs that specifically tar
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136 slides in two different concent
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138 Conclusions A strong network of
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140 tions introduced to ARE motifs
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142 Müller Beatrice U. | The maste
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144 A novel method was developed fo
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146 (SAKK 35-98) the Swiss Group fo
Page 150 and 151: 148 Timmermann Beate | Prospective
Page 152 and 153: 150 recurrence of the disease, we a
Page 154 and 155: 152 Zucca Emanuele | A prospective
Page 156 and 157: 154 Heinimann Karl | KFS 02489-08-2
Page 158 and 159: 156 Riggi Nicolò | BIL KFS 02717-0
Page 160 and 161: 158 activity at the single cell lev
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Page 164 and 165: 162 Körner Meike | In vitro evalua
Page 166 and 167: 164 Nadal David | Is endemic Burkit
Page 168 and 169: 166 (> 50.000/patient). For their a
Page 170 and 171: 168 Zeller Rolf | Functional analys
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Page 174 and 175: 172 area of health services researc
Page 176 and 177: 174 The financing of palliative car
Page 178 and 179: 176 National Strategy for Palliativ
Page 180 and 181: 178 Psychosocial research List of c
Page 182 and 183: 180 Within the patient group, level
Page 184 and 185: 182 Further, the results suggest th
Page 186 and 187: 184 It is in this context that the
Page 188 and 189: 186 Recommendation Female spouses o
Page 190 and 191: 188 Psychosocial research Presentat
Page 192 and 193: 190 rates communication skills rema
Page 195 and 196: Epidemiological research Epidemiolo
Page 197 and 198: data from cancer registries. In the
Page 199: The importance of cancer registries
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